中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
11期
976-978
,共3页
Photofrin光动力治疗%结直肠癌%青年%不良反应
Photofrin光動力治療%結直腸癌%青年%不良反應
Photofrin광동력치료%결직장암%청년%불량반응
Photofrin photodynamic adjuvant therapy%Colorectal cancer%Youth%Adverse reaction
目的 观察Photofrin光动力辅助治疗青年晚期结直肠癌的近期效果及不良反应.方法 选择我院2010年9月至2014年2月采用半导体激光光动力辅助治疗青年晚期结直肠癌患者共23例作为试验组,选择同期行放化疗的晚期结直肠癌患者30例作为对照组.试验组患者给予光敏剂Photofrin,以2 mg/kg速度静脉滴注,48 h后经内镜导入光导纤维,并给予630 nm强度的激光照射,2d后经内镜清除坏死组织并对原有病灶和新发现病灶给予复照,之后根据具体情况清除患者病灶部位坏死组织.对比分析两组患者的近期疗效及不良反应.结果 试验组患者的总有效率(69.57％)显著高于对照组(40.00％),差异有统计学意义(P=0.035).试验组住院时间显著少于对照组[(13.47±4.46)h和(19.72±5.21)h,差异有统计学意义(P=0.036).试验组的不良反应发生率(30.43％)显著低于对照组(50.00％),差异有统计学意义(P=0.021).结论 对青年晚期结直肠癌患者采用光动力治疗近期效果较好,可以有效改善临床症状,减少并发症.
目的 觀察Photofrin光動力輔助治療青年晚期結直腸癌的近期效果及不良反應.方法 選擇我院2010年9月至2014年2月採用半導體激光光動力輔助治療青年晚期結直腸癌患者共23例作為試驗組,選擇同期行放化療的晚期結直腸癌患者30例作為對照組.試驗組患者給予光敏劑Photofrin,以2 mg/kg速度靜脈滴註,48 h後經內鏡導入光導纖維,併給予630 nm彊度的激光照射,2d後經內鏡清除壞死組織併對原有病竈和新髮現病竈給予複照,之後根據具體情況清除患者病竈部位壞死組織.對比分析兩組患者的近期療效及不良反應.結果 試驗組患者的總有效率(69.57％)顯著高于對照組(40.00％),差異有統計學意義(P=0.035).試驗組住院時間顯著少于對照組[(13.47±4.46)h和(19.72±5.21)h,差異有統計學意義(P=0.036).試驗組的不良反應髮生率(30.43％)顯著低于對照組(50.00％),差異有統計學意義(P=0.021).結論 對青年晚期結直腸癌患者採用光動力治療近期效果較好,可以有效改善臨床癥狀,減少併髮癥.
목적 관찰Photofrin광동력보조치료청년만기결직장암적근기효과급불량반응.방법 선택아원2010년9월지2014년2월채용반도체격광광동력보조치료청년만기결직장암환자공23례작위시험조,선택동기행방화료적만기결직장암환자30례작위대조조.시험조환자급여광민제Photofrin,이2 mg/kg속도정맥적주,48 h후경내경도입광도섬유,병급여630 nm강도적격광조사,2d후경내경청제배사조직병대원유병조화신발현병조급여복조,지후근거구체정황청제환자병조부위배사조직.대비분석량조환자적근기료효급불량반응.결과 시험조환자적총유효솔(69.57％)현저고우대조조(40.00％),차이유통계학의의(P=0.035).시험조주원시간현저소우대조조[(13.47±4.46)h화(19.72±5.21)h,차이유통계학의의(P=0.036).시험조적불량반응발생솔(30.43％)현저저우대조조(50.00％),차이유통계학의의(P=0.021).결론 대청년만기결직장암환자채용광동력치료근기효과교호,가이유효개선림상증상,감소병발증.
Objective To observe the short-term efficacy and adverse drug reaction of Photofrin photodynamic adjuvant therapy for advanced colorectal cancer in young persons.Methods Selected 23 cases consecutives diagnosed as advanced colorectal cancer in young persons from September 2010 to February 2014 arriving in the Central Hospital of Jiangmen as the experiment group who were received Photofrin photodynamic therapy,and chose 30 consecutives diagnosed as advanced colorectal cancer as the control group who were received radiotherapy and chemotherapy.Using Photofrin in 2 mg/kg photosensitizer, the speed of intravenous infusion,48 hours after endoscopic into optical fiber, laser irradiation and treated with 630 nm intensity,2 days after endoscopic removal of necrotic tissue and the original lesions and new lesions were found to give according to the specific circumstances, after the removal of necrotic tissue lesions.Then compare the effects and complications.Results The total efficacy rate in experiment group was significantly more than control groupthe differences were significant (69.57％ vs.40.00％, P =0.035).The in-hospital time in experiment group was significantly less((13.47±4.46) h vs.(19.72± 5.21) h, P =0.036).The adverse drug reaction rate in experiment group was significantly lower thant the control group (30.43％ vs.50.00％ ,P=0.021).Conclusion The Photofrin photodynamic therapy for advanced colorectal cancer in young persons may greatly improve clinical effect and decrease complication.
