中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
11期
1000-1003
,共4页
容量负荷%心血管疾病%生物电阻抗分析%体液成分
容量負荷%心血管疾病%生物電阻抗分析%體液成分
용량부하%심혈관질병%생물전조항분석%체액성분
Volume load%Cardiovascular disease%Bioelectrical impedance analysis%Body fluid composition
目的 探讨成年女性容量状态与心血管疾病(CVD)危险因素相关性分析.方法 对来我院健康体检的成年女性进行横断面研究,收集体检者临床资料包括年龄、既往病史、吸烟史、饮酒史等,进行人体测量(身高、体质量、血压等),空腹抽血行血肌酐、血红蛋白、血糖、血尿酸、血脂等生化指标检测.采用人体成分分析仪测定研究对象的细胞外液(ECW),细胞内液(ICW),总水(TBW)等,应用ECW/TBW比值(E/T)评估容量状态.根据Watson公式计算人体总水(TBWwatson).根据CVD的主要危险因素(高血压、糖尿病、超重、脂代谢紊乱)将研究对象分为健康组、单危险因素组、聚集组(至少2个危险因素).E/T比值＜健康组10％的分位数值定义为低容量状态.应用多因素Logistic回归模型,探讨容量状态与CVD危险因素的关系.结果 共有2 433名成年女性纳入该研究,平均年龄为(37.4±7.3)岁,其中14.7％的成年女性存在CVD危险因素的聚集.聚集组低血容量比例明显高于单危险因素组及健康组,分别为18.2％、11.9％和6.7％,多组间比较差异有统计学意义(x2值为45.4,P＜0.001).多因素Logistic回归分析显示,在矫正了年龄、血红蛋白、血尿酸、肾小球滤过率(eGFR)后,低容量状态与CVD危险因素的聚集正相关,其中OR值为2.76,95％置信区间为1.93～ 3.95.结论 低容量状态与CVD危险因素的聚集相关,提示通过生活方式的干预可能会减低心血管疾病的聚集.
目的 探討成年女性容量狀態與心血管疾病(CVD)危險因素相關性分析.方法 對來我院健康體檢的成年女性進行橫斷麵研究,收集體檢者臨床資料包括年齡、既往病史、吸煙史、飲酒史等,進行人體測量(身高、體質量、血壓等),空腹抽血行血肌酐、血紅蛋白、血糖、血尿痠、血脂等生化指標檢測.採用人體成分分析儀測定研究對象的細胞外液(ECW),細胞內液(ICW),總水(TBW)等,應用ECW/TBW比值(E/T)評估容量狀態.根據Watson公式計算人體總水(TBWwatson).根據CVD的主要危險因素(高血壓、糖尿病、超重、脂代謝紊亂)將研究對象分為健康組、單危險因素組、聚集組(至少2箇危險因素).E/T比值＜健康組10％的分位數值定義為低容量狀態.應用多因素Logistic迴歸模型,探討容量狀態與CVD危險因素的關繫.結果 共有2 433名成年女性納入該研究,平均年齡為(37.4±7.3)歲,其中14.7％的成年女性存在CVD危險因素的聚集.聚集組低血容量比例明顯高于單危險因素組及健康組,分彆為18.2％、11.9％和6.7％,多組間比較差異有統計學意義(x2值為45.4,P＜0.001).多因素Logistic迴歸分析顯示,在矯正瞭年齡、血紅蛋白、血尿痠、腎小毬濾過率(eGFR)後,低容量狀態與CVD危險因素的聚集正相關,其中OR值為2.76,95％置信區間為1.93～ 3.95.結論 低容量狀態與CVD危險因素的聚集相關,提示通過生活方式的榦預可能會減低心血管疾病的聚集.
목적 탐토성년녀성용량상태여심혈관질병(CVD)위험인소상관성분석.방법 대래아원건강체검적성년녀성진행횡단면연구,수집체검자림상자료포괄년령、기왕병사、흡연사、음주사등,진행인체측량(신고、체질량、혈압등),공복추혈행혈기항、혈홍단백、혈당、혈뇨산、혈지등생화지표검측.채용인체성분분석의측정연구대상적세포외액(ECW),세포내액(ICW),총수(TBW)등,응용ECW/TBW비치(E/T)평고용량상태.근거Watson공식계산인체총수(TBWwatson).근거CVD적주요위험인소(고혈압、당뇨병、초중、지대사문란)장연구대상분위건강조、단위험인소조、취집조(지소2개위험인소).E/T비치＜건강조10％적분위수치정의위저용량상태.응용다인소Logistic회귀모형,탐토용량상태여CVD위험인소적관계.결과 공유2 433명성년녀성납입해연구,평균년령위(37.4±7.3)세,기중14.7％적성년녀성존재CVD위험인소적취집.취집조저혈용량비례명현고우단위험인소조급건강조,분별위18.2％、11.9％화6.7％,다조간비교차이유통계학의의(x2치위45.4,P＜0.001).다인소Logistic회귀분석현시,재교정료년령、혈홍단백、혈뇨산、신소구려과솔(eGFR)후,저용량상태여CVD위험인소적취집정상관,기중OR치위2.76,95％치신구간위1.93～ 3.95.결론 저용량상태여CVD위험인소적취집상관,제시통과생활방식적간예가능회감저심혈관질병적취집.
Objective To discuss the major cardiovascular disease(CVD) risk factors and volume load of women.Methods A cross-sectional study was conducted on adult women who came to our hospital for health examination.The clinical data included age, past medical history, smoking history, drinking history, body measurements (height, body weight, blood pressure, etc.), and blood serum creatinine, hemoglobin, blood glucose, blood lipid and other biochemical indicators were detected.Using the human body composition analyzer, the extracellular fluid (ECW), intracellular fluid (ICW), total water(TBW), and ECW/TBW ratio (E/T) were used to evaluate the capacity of the cells.Total body water(TBWwatson) was Calculated according to Watson formula.The clustering of four major CVD risk factors (defined as two or more of the following: hypertension, diabetes, dyslipidemia and overweight) and their association with volume load were investigated.Volume load was evaluated by bioelectrical impedance analysis.Hypovolaemia was defined as extracellular water/total body water (ECW/TBW) at and under the 10 percentile for the normal population.Logistic regression model was use to explore the relationship between capacity status and risk factors of CVD.Results A total of 2 433 women (mean age (37.4±7.3) years old) were enrolled in the study, 14.7％ of them had clustering of CVD risk factors.Hypovolaemia in clustering group was statistically higher than either in the single or in the none risk factor group, which was 18.2％, 11.9％, 6.7％, respectively (x2 =45.4, P＜0.001).After adjusted for potential confounders (including age, hemoglobin, serum uric acid, estimating glomerular filtration rate (eGFR), hypovolaemia was associated with clustering of CVD risk factors, with an OR of 2.76 (95％ CI 1.93-3.95).Conclusion Hypovolaemia is associated with clustering of major CVD risk factors in women, which further confirms the importance of modifying lifestyle to reduce the burden of CVD.
