CAJ | 학술논문

目的：观察神经干细胞移植治疗脑梗死的临床疗效。方法将60例脑梗死患者随机分为静脉注射组14例，腰椎穿刺组18例和对照组28例，对照组给予常规治疗；除常规治疗外，静脉注射组经肘静脉输注神经干细胞；腰椎穿刺组通过腰椎穿刺蛛网膜下腔植入神经干细胞。3组治疗前后均行功能独立性量表（FIM ）评分。结果治疗前，对照组、静脉注射组、腰椎穿刺组的FIM 评分比较差异无统计学意义（ P＞0.05）；治疗后，静脉注射组和腰椎穿刺组与对照组的FIM 评分比较差异有统计学意义（ P＜0.05）；治疗后，腰椎穿刺组与静脉穿刺组的FIM 评分比较差异有统计学意义（ P＜0.05）。结论神经干细胞是治疗脑梗死的一种有效方法，尤其是采用腰椎穿刺经蛛网膜下腔注射神经干细胞可明显改善脑梗死患者的预后，提高其生存质量。
목적：관찰신경간세포이식치료뇌경사적림상료효。방법장60례뇌경사환자수궤분위정맥주사조14례，요추천자조18례화대조조28례，대조조급여상규치료；제상규치료외，정맥주사조경주정맥수주신경간세포；요추천자조통과요추천자주망막하강식입신경간세포。3조치료전후균행공능독립성량표（FIM ）평분。결과치료전，대조조、정맥주사조、요추천자조적FIM 평분비교차이무통계학의의（ P＞0.05）；치료후，정맥주사조화요추천자조여대조조적FIM 평분비교차이유통계학의의（ P＜0.05）；치료후，요추천자조여정맥천자조적FIM 평분비교차이유통계학의의（ P＜0.05）。결론신경간세포시치료뇌경사적일충유효방법，우기시채용요추천자경주망막하강주사신경간세포가명현개선뇌경사환자적예후，제고기생존질량。
Objective To observe the clinical effect of neural stem cell transplantation in the treatment of cerebral infarc‐tion.Methods 60 cases with cerebral infarction were randomly divided into intravenous injection group (14 cases) ,lumbar puncture (18 cases) and control group (28 cases). Patients in control group were given routine therapy. Besides routine treat‐ment ,the intravenous injection group received neural stem cells infusion by elbow vein injection ;patients in the lumbar punc‐ture group were implanted into neural stem cells through the lumbar puncture. The functional independence scale (FIM ) of the three groups were performed before and after treatment.Results Before treatment ,the FIM scores in the control group ,intra‐venous injection group and lumbar puncture group showed no statistically significant differences (P>0.05);After treatment , compared with control group ,FIM scores in intravenous group and lumbar puncture group revealed statistically significant difference (P<0.05). After treatment ,the difference of FIM scores between intravenous group and lumbar puncture group was a statistical significant (P<0.05).Conclusion Neural stem cells is an effective method in the treatment of cerebral infarc‐tion ,especially the application of subarachnoid cavity injection by lumbar puncture method can significantly improve the prog‐nosis of patients with cerebral infarction and enhance their quality of life.