中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
31期
56-58
,共3页
冠心病%血尿酸%心功能不全%相关性
冠心病%血尿痠%心功能不全%相關性
관심병%혈뇨산%심공능불전%상관성
Coronary disease%Serum uric acid%Cardiac insufficiency%Correlation
目的：分析血尿酸水平与冠心病慢性心功能不全（CHF）的相关性。方法：将确诊为冠心病的325例患者依据心功能情况分为两组，心功能正常组192例，心功能不全组133例。心功能不全组按纽约心功能分级标准分为Ⅱ~Ⅳ级；采用尿酸氧化酶法测定空腹血尿酸浓度；运用统计学方法分析患者血尿酸浓度与心功能程度的相关性。结果：心功能正常组和心功能不全组患者性别、年龄方面比较差异有统计学意义（P<0.05）。心功能正常组血尿酸浓度为（325.87±91.32）μmol/L，高尿酸血症（HUA）发生率为20.31%；心功能不全组血尿酸浓度为（424.85±102.23）μmol/L，HUA发生率为48.87%，两组比较差异有统计学意义（P<0.01）。随着心功能分级的增高，患者的血尿酸浓度逐渐增高，高尿酸血症发生率也逐渐升高，比较差异有统计学意义（P<0.01）。结论：冠心病心功能不全患者的血尿酸浓度高于心功能正常患者，并随着心功能的下降而不断升高，同时，高尿酸血症发生率也会增加，血尿酸水平与心功能分级呈正相关。
目的：分析血尿痠水平與冠心病慢性心功能不全（CHF）的相關性。方法：將確診為冠心病的325例患者依據心功能情況分為兩組，心功能正常組192例，心功能不全組133例。心功能不全組按紐約心功能分級標準分為Ⅱ~Ⅳ級；採用尿痠氧化酶法測定空腹血尿痠濃度；運用統計學方法分析患者血尿痠濃度與心功能程度的相關性。結果：心功能正常組和心功能不全組患者性彆、年齡方麵比較差異有統計學意義（P<0.05）。心功能正常組血尿痠濃度為（325.87±91.32）μmol/L，高尿痠血癥（HUA）髮生率為20.31%；心功能不全組血尿痠濃度為（424.85±102.23）μmol/L，HUA髮生率為48.87%，兩組比較差異有統計學意義（P<0.01）。隨著心功能分級的增高，患者的血尿痠濃度逐漸增高，高尿痠血癥髮生率也逐漸升高，比較差異有統計學意義（P<0.01）。結論：冠心病心功能不全患者的血尿痠濃度高于心功能正常患者，併隨著心功能的下降而不斷升高，同時，高尿痠血癥髮生率也會增加，血尿痠水平與心功能分級呈正相關。
목적：분석혈뇨산수평여관심병만성심공능불전（CHF）적상관성。방법：장학진위관심병적325례환자의거심공능정황분위량조，심공능정상조192례，심공능불전조133례。심공능불전조안뉴약심공능분급표준분위Ⅱ~Ⅳ급；채용뇨산양화매법측정공복혈뇨산농도；운용통계학방법분석환자혈뇨산농도여심공능정도적상관성。결과：심공능정상조화심공능불전조환자성별、년령방면비교차이유통계학의의（P<0.05）。심공능정상조혈뇨산농도위（325.87±91.32）μmol/L，고뇨산혈증（HUA）발생솔위20.31%；심공능불전조혈뇨산농도위（424.85±102.23）μmol/L，HUA발생솔위48.87%，량조비교차이유통계학의의（P<0.01）。수착심공능분급적증고，환자적혈뇨산농도축점증고，고뇨산혈증발생솔야축점승고，비교차이유통계학의의（P<0.01）。결론：관심병심공능불전환자적혈뇨산농도고우심공능정상환자，병수착심공능적하강이불단승고，동시，고뇨산혈증발생솔야회증가，혈뇨산수평여심공능분급정정상관。
Objective:To analyze correlation between serum uric acid (SUA) and chronic cardiac insufficiency of patients with coronary heart diseases.Method: 325 patients with coronary heart diseases were divided into 2 groups, normal cardiac function group (192 cases) and cardiac dysfunction group (133 cases). According to the New York Heart Association (NYHA) criteria, 133 cardiac dysfunction patients were divided into Ⅱ-Ⅳ grades. The level of serum uric acid was measured by urate oxidase method. The correlation between the level of serum uric acid and cardiac function was analyzed by statistical method.Result: There were statistically significant differences in sex, age between the two groups (P<0.05). The mean serum uric acid level of the normal cardiac function group was (325.87±91.32)μmol/L, and the incidence of hyperuricemia (HUA) was 20.31%. The mean serum uric acid level of the cardiac dysfunction group was (424.85±102.23)μmol/L, and the incidence of HUA was 48.87%. There were statistically significant differences between the two groups (P<0.01). With cardiac functional grade increasing,the level of serum uric acid and the incidence of hyperuricemia gradually increased, and there were significant differences (P<0.01).Conclusion:The mean serum uric acid level in patients with cardiac dysfunction is higher than patients with normal cardiac function group, and with the decline of cardiac function, the mean serum uric acid level elevated, and the incidence of HUA elevated too. There is a positive correlation between the level of serum uric acid and the cardiac functional grade.
