中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
31期
26-28
,共3页
微小残留病灶%急性淋巴细胞白血病%预后%复发
微小殘留病竈%急性淋巴細胞白血病%預後%複髮
미소잔류병조%급성림파세포백혈병%예후%복발
Minimal residual disease%Acute lymphoblastic leukemia%Prognosis%Recurrence
目的：探讨微小残留病灶（MRD）检测对急性淋巴细胞白血病（ALL）预后判断的临床价值。方法：选取本院收治的120例ALL患者作为研究对象，于诱导缓解治疗第33天、维持治疗第3个月分别对患者进行骨髓MRD检测，统计MRD阳性及阴性患者不同危险度及不同治疗时期的复发情况，同时比较诱导缓解治疗第33天不同骨髓缓解状况下MRD水平。结果：诱导缓解治疗第33天以及维持治疗第3个月，高危组的MRD阳性率均显著高于中危组及低危组，差异有统计学意义（P<0.01）；不同治疗时期MRD阳性复发率显著高于MRD阴性复发率，差异有统计学意义（P<0.05）；诱导缓解治疗第33天骨髓象达M1的患者MRD≥10-2比例显著低于M2与M3组，差异有统计学意义（P<0.01）；诱导缓解治疗第33天骨髓象达M1患者的复发率显著低于M2与M3组，差异有统计学意义（P<0.01）。结论：MRD水平与ALL的预后有关，MRD阳性可作为ALL患者预后判断的重要因素。
目的：探討微小殘留病竈（MRD）檢測對急性淋巴細胞白血病（ALL）預後判斷的臨床價值。方法：選取本院收治的120例ALL患者作為研究對象，于誘導緩解治療第33天、維持治療第3箇月分彆對患者進行骨髓MRD檢測，統計MRD暘性及陰性患者不同危險度及不同治療時期的複髮情況，同時比較誘導緩解治療第33天不同骨髓緩解狀況下MRD水平。結果：誘導緩解治療第33天以及維持治療第3箇月，高危組的MRD暘性率均顯著高于中危組及低危組，差異有統計學意義（P<0.01）；不同治療時期MRD暘性複髮率顯著高于MRD陰性複髮率，差異有統計學意義（P<0.05）；誘導緩解治療第33天骨髓象達M1的患者MRD≥10-2比例顯著低于M2與M3組，差異有統計學意義（P<0.01）；誘導緩解治療第33天骨髓象達M1患者的複髮率顯著低于M2與M3組，差異有統計學意義（P<0.01）。結論：MRD水平與ALL的預後有關，MRD暘性可作為ALL患者預後判斷的重要因素。
목적：탐토미소잔류병조（MRD）검측대급성림파세포백혈병（ALL）예후판단적림상개치。방법：선취본원수치적120례ALL환자작위연구대상，우유도완해치료제33천、유지치료제3개월분별대환자진행골수MRD검측，통계MRD양성급음성환자불동위험도급불동치료시기적복발정황，동시비교유도완해치료제33천불동골수완해상황하MRD수평。결과：유도완해치료제33천이급유지치료제3개월，고위조적MRD양성솔균현저고우중위조급저위조，차이유통계학의의（P<0.01）；불동치료시기MRD양성복발솔현저고우MRD음성복발솔，차이유통계학의의（P<0.05）；유도완해치료제33천골수상체M1적환자MRD≥10-2비례현저저우M2여M3조，차이유통계학의의（P<0.01）；유도완해치료제33천골수상체M1환자적복발솔현저저우M2여M3조，차이유통계학의의（P<0.01）。결론：MRD수평여ALL적예후유관，MRD양성가작위ALL환자예후판단적중요인소。
Objective:To investigate the clinical value of the detection of minimal residual disease (MRD) in the prognosis of acute lymphoblastic leukemia (ALL).Method:120 patients with ALL were selected as the research objects, they were treated in the induction of remission in thirty-third days and maintenance therapy in the third months with bone marrow MRD detection, the MRD positive and negative patients with different risk and treatment period of relapse were compared. At the same time,the different bone marrow MRD levels of the induction of remission in thirty-third days were compared.Result:The induction of remission in the treatment of the thirty-third days and maintenance therapy in the third months, MRD positive rate of high risk group was significantly higher than that in middle risk group and low-risk group, the differences were statistically significant(P<0.01);different treatment period MRD positive recurrence rate was significantly higher than that of MRD negative recurrence rate,the difference was statistically significant (P<0.05);remission induction therapy with the thirty-third days bone marrow of M1 with minimal residual disease (MRD)≥10-2 was significantly lower than that of M2 and M3 group,the difference was statistically significant(P<0.01);remission induction in the treatment of the thirty-third days bone marrow of M1 recurrence rate was significantly lower than that of M2 and M3 group,the difference was statistically significant(P<0.01).Conclusion:MRD level is related to the prognosis of ALL and MRD positive can be used as an important factor for the prognosis of ALL patients.
