中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
11期
982-985
,共4页
郑梅%闫颖%张爱莲%张艳雯%赵兴山
鄭梅%閆穎%張愛蓮%張豔雯%趙興山
정매%염영%장애련%장염문%조흥산
急性心肌梗死%Chemerin%脂肪因子%炎症因子
急性心肌梗死%Chemerin%脂肪因子%炎癥因子
급성심기경사%Chemerin%지방인자%염증인자
Acute myocardial Infarction%Chemerin%Fat factor%Inflammatory factor
目的 观察急性心肌梗死患者血清脂肪细胞因子(Chemerin)的水平变化,探讨其在急性心肌梗死发生发展过程中的作用.方法 采用临床病例对照研究,以2013年1-12月在我院心内科就诊的76例急性心肌梗死患者为研究对象,以我院同期健康体检者30名为健康对照组,采用双抗体夹心法酶联免疫吸附法检测两组研究对象血清Chemerin、肿瘤坏死因子α(TNF-α)、脂联素,同时收集患者超敏C反应蛋白(hs-CRP)、体质量指数(BMI)、血脂、基础疾病等临床资料.结果 急性心肌梗死组血清Chemerin水平明显高于健康对照组[(12.97±4.17)、(30.96±17.16) μg/L],差异有统计学意义(t=5.642,P＜0.001),急性心肌梗死单支病变组、双支病变组和三支病变组患者的血清Chemerin依次为(22.25±6.93)、(28.57±15.92)、(37.95±16.52) μg/L,随着心脏血管病变程度增加,Chemerin水平呈增高趋势(F=22.840,P＜0.001,r2=0.397),Chemerin与TNF-α、hs-CRP水平呈正相关(r2值分别为0.347、0.455,P均＜0.001),而与脂联素水平呈负相关(r2=0.39,P＜0.001).Logistic多元回归分析结果显示,Chemerin为急性心肌梗死独立危险因素之一(OR=4.822,95％CI为4.422～7.141,P=0.032).结论 急性心肌梗死患者血清Chemerin水平升高,可能参与了急性心肌梗死的发生发展过程.
目的 觀察急性心肌梗死患者血清脂肪細胞因子(Chemerin)的水平變化,探討其在急性心肌梗死髮生髮展過程中的作用.方法 採用臨床病例對照研究,以2013年1-12月在我院心內科就診的76例急性心肌梗死患者為研究對象,以我院同期健康體檢者30名為健康對照組,採用雙抗體夾心法酶聯免疫吸附法檢測兩組研究對象血清Chemerin、腫瘤壞死因子α(TNF-α)、脂聯素,同時收集患者超敏C反應蛋白(hs-CRP)、體質量指數(BMI)、血脂、基礎疾病等臨床資料.結果 急性心肌梗死組血清Chemerin水平明顯高于健康對照組[(12.97±4.17)、(30.96±17.16) μg/L],差異有統計學意義(t=5.642,P＜0.001),急性心肌梗死單支病變組、雙支病變組和三支病變組患者的血清Chemerin依次為(22.25±6.93)、(28.57±15.92)、(37.95±16.52) μg/L,隨著心髒血管病變程度增加,Chemerin水平呈增高趨勢(F=22.840,P＜0.001,r2=0.397),Chemerin與TNF-α、hs-CRP水平呈正相關(r2值分彆為0.347、0.455,P均＜0.001),而與脂聯素水平呈負相關(r2=0.39,P＜0.001).Logistic多元迴歸分析結果顯示,Chemerin為急性心肌梗死獨立危險因素之一(OR=4.822,95％CI為4.422～7.141,P=0.032).結論 急性心肌梗死患者血清Chemerin水平升高,可能參與瞭急性心肌梗死的髮生髮展過程.
목적 관찰급성심기경사환자혈청지방세포인자(Chemerin)적수평변화,탐토기재급성심기경사발생발전과정중적작용.방법 채용림상병례대조연구,이2013년1-12월재아원심내과취진적76례급성심기경사환자위연구대상,이아원동기건강체검자30명위건강대조조,채용쌍항체협심법매련면역흡부법검측량조연구대상혈청Chemerin、종류배사인자α(TNF-α)、지련소,동시수집환자초민C반응단백(hs-CRP)、체질량지수(BMI)、혈지、기출질병등림상자료.결과 급성심기경사조혈청Chemerin수평명현고우건강대조조[(12.97±4.17)、(30.96±17.16) μg/L],차이유통계학의의(t=5.642,P＜0.001),급성심기경사단지병변조、쌍지병변조화삼지병변조환자적혈청Chemerin의차위(22.25±6.93)、(28.57±15.92)、(37.95±16.52) μg/L,수착심장혈관병변정도증가,Chemerin수평정증고추세(F=22.840,P＜0.001,r2=0.397),Chemerin여TNF-α、hs-CRP수평정정상관(r2치분별위0.347、0.455,P균＜0.001),이여지련소수평정부상관(r2=0.39,P＜0.001).Logistic다원회귀분석결과현시,Chemerin위급성심기경사독립위험인소지일(OR=4.822,95％CI위4.422～7.141,P=0.032).결론 급성심기경사환자혈청Chemerin수평승고,가능삼여료급성심기경사적발생발전과정.
Objective To investigate the levels of serum chemerin in the acute myocardial infarction (AMI) patients and explore the clinical significance.Methods A total of 76 AMI patients from January 2013 to December 2013 were inrolled and 30 healthy patients were included as normal control(NC) group.Chemerin, tumor necrosis factor α(TNF-α), adiponectin were asessed by enzyme linked immunosorbent assay(ELlSA).The clinical data of high sensitivity C reactive protein (hs-CRP), body mass index (BMI), blood lipids, underlying diseases et al were collected.Results Serum levels of chemerin in AMI patients was higher than the NC group significantly((12.97±4.17) μg/L vs.(30.96± 17.16) μg/L, t =5.642, P＜0.001).The Serum levels of Chemerin in single vessel disease group, two vessel disease group and triple vessel disease group were (22.25 ± ±6.93) μg/L, (28.57 ± 15.92) μg/L, (37.95 ± 16.52) μg/L respectively and was linearly increasing relationship with increasing AMI severity (P＜0.001, F =22.84, r2 =0.397).Serum levels of Chemerin positively correlated with TNF-α, hs-CRP level(r2=0.347,0.455 ,P＜0.001) and negative correlated with adiponectin(r2 =0.396,P＜0.001).Logistic regression analysis showed that chemerin was an independent risk factor for AMI (OR =4.822,95％ CI 4.422-7.141, P =0.032).Conclusion The results showed that serum chemerin levels were significantly elevated in AMI patients,and chemerin may be involved in the development process of AMI.
