中国现代药物应用
中國現代藥物應用
중국현대약물응용
Chinese Journal of Modern Drug Application
2015年
22期
276-277
,共2页
白细胞介素-1β%术后认知功能障碍%辛伐他汀
白細胞介素-1β%術後認知功能障礙%辛伐他汀
백세포개소-1β%술후인지공능장애%신벌타정
Interleukin-1β%Postoperative cognitive dysfunction%Simvastatin
目的 探讨辛伐他汀对术后白细胞介素-1β(IL-1β)及认知功能障碍是否有影响, 从而为临床提供参考.方法 选择72只雄性SD大鼠随机分为对照组(A组)和实验组(B组), 各36例.对照组(A组)用生理盐水喂饲7 d, 实验组(B组)用辛伐他汀(10 mg/kg)喂饲7 d.在喂饲7 d后行切脾手术, A、B组随机分为4个亚组(A0、A1、A3、A7组和B0、B1、B3、B7组, n=9)分别于术前和术后第1、3、7天通过Y型迷宫测试大鼠的认知功能及检测外周血IL-1β表达.结果 术后各亚组认知功能比较差异无统计学意义(P>0.05), 对照组中IL-1β水平手术与非手术组比较差异无统计学意义(P>0.05), 实验组与对照组比较差异无统计学意义(P>0.05).结论 切脾手术未能引起青年鼠术后认知功能障碍, 也未能使青年鼠外周血IL-1β水平升高.辛伐他汀可能并不抑制外周IL-1β的水平, 对术后认知功能障碍的发生也无影响.
目的 探討辛伐他汀對術後白細胞介素-1β(IL-1β)及認知功能障礙是否有影響, 從而為臨床提供參攷.方法 選擇72隻雄性SD大鼠隨機分為對照組(A組)和實驗組(B組), 各36例.對照組(A組)用生理鹽水餵飼7 d, 實驗組(B組)用辛伐他汀(10 mg/kg)餵飼7 d.在餵飼7 d後行切脾手術, A、B組隨機分為4箇亞組(A0、A1、A3、A7組和B0、B1、B3、B7組, n=9)分彆于術前和術後第1、3、7天通過Y型迷宮測試大鼠的認知功能及檢測外週血IL-1β錶達.結果 術後各亞組認知功能比較差異無統計學意義(P>0.05), 對照組中IL-1β水平手術與非手術組比較差異無統計學意義(P>0.05), 實驗組與對照組比較差異無統計學意義(P>0.05).結論 切脾手術未能引起青年鼠術後認知功能障礙, 也未能使青年鼠外週血IL-1β水平升高.辛伐他汀可能併不抑製外週IL-1β的水平, 對術後認知功能障礙的髮生也無影響.
목적 탐토신벌타정대술후백세포개소-1β(IL-1β)급인지공능장애시부유영향, 종이위림상제공삼고.방법 선택72지웅성SD대서수궤분위대조조(A조)화실험조(B조), 각36례.대조조(A조)용생리염수위사7 d, 실험조(B조)용신벌타정(10 mg/kg)위사7 d.재위사7 d후행절비수술, A、B조수궤분위4개아조(A0、A1、A3、A7조화B0、B1、B3、B7조, n=9)분별우술전화술후제1、3、7천통과Y형미궁측시대서적인지공능급검측외주혈IL-1β표체.결과 술후각아조인지공능비교차이무통계학의의(P>0.05), 대조조중IL-1β수평수술여비수술조비교차이무통계학의의(P>0.05), 실험조여대조조비교차이무통계학의의(P>0.05).결론 절비수술미능인기청년서술후인지공능장애, 야미능사청년서외주혈IL-1β수평승고.신벌타정가능병불억제외주IL-1β적수평, 대술후인지공능장애적발생야무영향.
Objective To investigate if simvastatin has influence on postoperative interleukin-1β (IL-1β) and cognitive dysfunction, so as to provide clinical reference.Methods A total of 72 male SD rats were randomly divided into control group (group A) and experimental group (group B), with 36 cases in each group. The control group received normal saline feeding for 7 d, and the experimental group received simvastatin (10 mg/kg) feeding for 7 d. They received splenectomy after 7 d of feeding. Groups A and B were randomly divided into 4 groups A0, A1, A3, A7 and B0, B1, B3, B7, n=9), and they received detection of cognitive function by Y-maze test and peripheral blood IL-1β in 1, 3, 7 d before and after surgery.Results There was no statistically significant difference of postoperative cognitive function in all groups (P>0.05). The difference of IL-1β between surgery group and non-surgery group among the control group had no statistical significance (P>0.05). The difference between the experimental group and control group had no statistical significance (P>0.05).Conclusion Splenectomy does not lead to postoperative cognitive dysfunction or increasing peripheral blood IL-1β in rats. Simvastatin has no influence on peripheral blood IL-1β level or postoperative cognitive dysfunction.
