实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
10期
112-114,117
,共4页
王永%刘勇%朱宝山%范远威
王永%劉勇%硃寶山%範遠威
왕영%류용%주보산%범원위
肺源性心脏病%心力衰竭%老年人%参麦注射液%连续气道正压通气%D-二聚体%N-末端脑利钠肽前体
肺源性心髒病%心力衰竭%老年人%參麥註射液%連續氣道正壓通氣%D-二聚體%N-末耑腦利鈉肽前體
폐원성심장병%심력쇠갈%노년인%삼맥주사액%련속기도정압통기%D-이취체%N-말단뇌리납태전체
Pulmonary heart disease%Heart failure%Aged%Shenmai injection%Continuous positive airway pressure%D - dimer%N - terminal pro - brain natriuretic peptide
目的：探讨参麦注射液联合无创双水平气道正压通气（BiPAP）治疗老年慢性肺源性心脏病（CPHD）合并心力衰竭的临床疗效，并观察其对血清 D -二聚体及 N -末端脑利钠肽前体（NT - proBNP）水平的影响。方法选取2011—2014年新沂市铁路医院收治的老年 CPHD 合并心力衰竭患者96例，按就诊顺序单双号分为治疗组和对照组，每组48例。两组患者均给予常规治疗，对照组患者在常规治疗基础上采用复方丹参注射液治疗，治疗组患者在常规治疗基础上采用参麦注射液联合 BiPAP 治疗；两组患者均治疗10 d。比较两组患者的临床疗效，治疗前后血清 D -二聚体、NT - proBNP 水平及治疗后纽约心脏病协会（NYHA）心功能分级，并观察两组患者不良反应发生情况。结果治疗组患者临床疗效优于对照组（u =2.370，P ﹤0.05）。治疗前两组患者血清 D -二聚体、NT - proBNP 水平比较，差异无统计学意义（P ﹥0.05）；治疗后治疗组患者血清 D -二聚体、NT - proBNP 水平均低于对照组（P ﹤0.01）。治疗组患者治疗后 NYHA 心功能分级优于对照组（u =2.274，P =0.023）。两组患者均未出现严重的不良反应。结论参麦注射液联合 BiPAP 治疗 CPHD 合并心力衰竭的临床疗效确切，能有效改善患者心功能，降低血清 D -二聚体及 NT- proBNP 水平，且无严重不良反应。
目的：探討參麥註射液聯閤無創雙水平氣道正壓通氣（BiPAP）治療老年慢性肺源性心髒病（CPHD）閤併心力衰竭的臨床療效，併觀察其對血清 D -二聚體及 N -末耑腦利鈉肽前體（NT - proBNP）水平的影響。方法選取2011—2014年新沂市鐵路醫院收治的老年 CPHD 閤併心力衰竭患者96例，按就診順序單雙號分為治療組和對照組，每組48例。兩組患者均給予常規治療，對照組患者在常規治療基礎上採用複方丹參註射液治療，治療組患者在常規治療基礎上採用參麥註射液聯閤 BiPAP 治療；兩組患者均治療10 d。比較兩組患者的臨床療效，治療前後血清 D -二聚體、NT - proBNP 水平及治療後紐約心髒病協會（NYHA）心功能分級，併觀察兩組患者不良反應髮生情況。結果治療組患者臨床療效優于對照組（u =2.370，P ﹤0.05）。治療前兩組患者血清 D -二聚體、NT - proBNP 水平比較，差異無統計學意義（P ﹥0.05）；治療後治療組患者血清 D -二聚體、NT - proBNP 水平均低于對照組（P ﹤0.01）。治療組患者治療後 NYHA 心功能分級優于對照組（u =2.274，P =0.023）。兩組患者均未齣現嚴重的不良反應。結論參麥註射液聯閤 BiPAP 治療 CPHD 閤併心力衰竭的臨床療效確切，能有效改善患者心功能，降低血清 D -二聚體及 NT- proBNP 水平，且無嚴重不良反應。
목적：탐토삼맥주사액연합무창쌍수평기도정압통기（BiPAP）치료노년만성폐원성심장병（CPHD）합병심력쇠갈적림상료효，병관찰기대혈청 D -이취체급 N -말단뇌리납태전체（NT - proBNP）수평적영향。방법선취2011—2014년신기시철로의원수치적노년 CPHD 합병심력쇠갈환자96례，안취진순서단쌍호분위치료조화대조조，매조48례。량조환자균급여상규치료，대조조환자재상규치료기출상채용복방단삼주사액치료，치료조환자재상규치료기출상채용삼맥주사액연합 BiPAP 치료；량조환자균치료10 d。비교량조환자적림상료효，치료전후혈청 D -이취체、NT - proBNP 수평급치료후뉴약심장병협회（NYHA）심공능분급，병관찰량조환자불량반응발생정황。결과치료조환자림상료효우우대조조（u =2.370，P ﹤0.05）。치료전량조환자혈청 D -이취체、NT - proBNP 수평비교，차이무통계학의의（P ﹥0.05）；치료후치료조환자혈청 D -이취체、NT - proBNP 수평균저우대조조（P ﹤0.01）。치료조환자치료후 NYHA 심공능분급우우대조조（u =2.274，P =0.023）。량조환자균미출현엄중적불량반응。결론삼맥주사액연합 BiPAP 치료 CPHD 합병심력쇠갈적림상료효학절，능유효개선환자심공능，강저혈청 D -이취체급 NT- proBNP 수평，차무엄중불량반응。
Objective To investigate the clinical effect of shenmai injection combined with non - invasive bi - level positive airway pressure( BiPAP) ventilation on elderly chronic pulmonary heart disease( CPHD) patients complicated with heart failure and its impact on serum levels of D - dimer and N - terminal pro - brain natriuretic peptide( NT - proBNP). Methods A total of 96 elderly CPHD patients complicated with heart failure were selected in Railway Hospital of Xinyi from 2011 to 2014,and they were divided into control group and treatment group according to odd or even number of visiting sequence,each of 48 cases. Based on the conventional treatment,patients of control group were given extra compound danshen injection,while patients of treatment group were given extra shenmai injection combined with BiPAP ventilation,both groups treated for 10 days. Clinical effect,serum levels of D - dimer and NT - proBNP before and after treatment,NYHA cardiac functional grading after treatment were compared between the two groups,and incidence of adverse reactions was observed. Results The clinical effect of treatment group was statistically significantly better than that of control group(u = 2. 370,P ﹤ 0. 05). No statistically significant differences of serum level of D - dimer or NT - proBNP was found between the two groups before treatment(P ﹥ 0. 05),while serum levels of D - dimer and NT - proBNP of treatment group were statistically significantly lower than those of control group after treatment(P ﹤ 0. 01). NYHA cardiac functional grading after treatment of treatment group was statistically significantly better than that of control group(u = 2. 274,P = 0. 023). No one of the two groups occurred any serious adverse reactions. Conclusion Shenmai injection combined with BiPAP ventilation has certain clinical effect in treating elderly CPHD patients complicated with heart failure,can effectively improve the cardiac function,reduce the serum levels of D- dimer and NT - proBNP without serious adverse reactions.
