实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
10期
102-105
,共4页
高血压%血压监测仪%昼夜节律%疾病特征%时间治疗学
高血壓%血壓鑑測儀%晝夜節律%疾病特徵%時間治療學
고혈압%혈압감측의%주야절률%질병특정%시간치료학
Hypertension%Blood pressure monitors%Circadian rhythm%Disease attributes%Chronotherapeutics
目的：分析夜间高血压患者临床特征及治疗。方法选择北京燕化医院心内科2013年9月—2014年9月收治的门诊和住院高血压3级患者200例，根据24 h 动态血压监测结果分为夜间高血压组100例和非夜间高血压组100例，再根据服药频率将夜间高血压组患者分为 A 组和 B 组，各50例。A、B 两组患者均接受非药物治疗，在此基础上，A 组患者清晨服用非洛地平缓释片10 mg +盐酸贝那普利10 mg；B 组患者清晨服用非洛地平缓释片5 mg +盐酸贝那普利10 mg，17：00加服非洛地平缓释片5 mg。比较夜间高血压组与非夜间高血压组患者临床特征、A 组与 B 组患者治疗效果及治疗前后血压变异性。结果夜间高血压组与非夜间高血压组患者性别、年龄、高血压病程、合并症、昼间平均收缩压、昼间平均舒张压及非杓型血压所占比例比较，差异均无统计学意义（P ﹥0.05）；夜间高血压组患者夜间平均收缩压、夜间平均舒张压高于非夜间高血压组（P ﹤0.05）。A 组与 B 组患者治疗前昼间平均收缩压、昼间平均舒张压、夜间平均收缩压、夜间平均舒张压比较，差异均无统计学意义（P ﹥0.05）。A 组与 B 组患者治疗后昼间平均收缩压、昼间平均舒张压比较，差异均无统计学意义（P ﹥0.05）；B 组患者治疗后夜间平均收缩压、夜间平均舒张压低于 A 组（P ﹤0.05）。A 组与 B 组患者治疗前血压变异性比较，差异无统计学意义（P ﹥0.05）；治疗后 B 组患者血压变异性优于 A 组（P ﹤0.05）。结论与非夜间高血压患者相比，夜间高血压患者临床表现无特异性，主要以夜间血压升高为主，傍晚加服非洛地平缓释片可有效提高夜间高血压患者治疗效果，优化血压昼夜节律。
目的：分析夜間高血壓患者臨床特徵及治療。方法選擇北京燕化醫院心內科2013年9月—2014年9月收治的門診和住院高血壓3級患者200例，根據24 h 動態血壓鑑測結果分為夜間高血壓組100例和非夜間高血壓組100例，再根據服藥頻率將夜間高血壓組患者分為 A 組和 B 組，各50例。A、B 兩組患者均接受非藥物治療，在此基礎上，A 組患者清晨服用非洛地平緩釋片10 mg +鹽痠貝那普利10 mg；B 組患者清晨服用非洛地平緩釋片5 mg +鹽痠貝那普利10 mg，17：00加服非洛地平緩釋片5 mg。比較夜間高血壓組與非夜間高血壓組患者臨床特徵、A 組與 B 組患者治療效果及治療前後血壓變異性。結果夜間高血壓組與非夜間高血壓組患者性彆、年齡、高血壓病程、閤併癥、晝間平均收縮壓、晝間平均舒張壓及非杓型血壓所佔比例比較，差異均無統計學意義（P ﹥0.05）；夜間高血壓組患者夜間平均收縮壓、夜間平均舒張壓高于非夜間高血壓組（P ﹤0.05）。A 組與 B 組患者治療前晝間平均收縮壓、晝間平均舒張壓、夜間平均收縮壓、夜間平均舒張壓比較，差異均無統計學意義（P ﹥0.05）。A 組與 B 組患者治療後晝間平均收縮壓、晝間平均舒張壓比較，差異均無統計學意義（P ﹥0.05）；B 組患者治療後夜間平均收縮壓、夜間平均舒張壓低于 A 組（P ﹤0.05）。A 組與 B 組患者治療前血壓變異性比較，差異無統計學意義（P ﹥0.05）；治療後 B 組患者血壓變異性優于 A 組（P ﹤0.05）。結論與非夜間高血壓患者相比，夜間高血壓患者臨床錶現無特異性，主要以夜間血壓升高為主，傍晚加服非洛地平緩釋片可有效提高夜間高血壓患者治療效果，優化血壓晝夜節律。
목적：분석야간고혈압환자림상특정급치료。방법선택북경연화의원심내과2013년9월—2014년9월수치적문진화주원고혈압3급환자200례，근거24 h 동태혈압감측결과분위야간고혈압조100례화비야간고혈압조100례，재근거복약빈솔장야간고혈압조환자분위 A 조화 B 조，각50례。A、B 량조환자균접수비약물치료，재차기출상，A 조환자청신복용비락지평완석편10 mg +염산패나보리10 mg；B 조환자청신복용비락지평완석편5 mg +염산패나보리10 mg，17：00가복비락지평완석편5 mg。비교야간고혈압조여비야간고혈압조환자림상특정、A 조여 B 조환자치료효과급치료전후혈압변이성。결과야간고혈압조여비야간고혈압조환자성별、년령、고혈압병정、합병증、주간평균수축압、주간평균서장압급비표형혈압소점비례비교，차이균무통계학의의（P ﹥0.05）；야간고혈압조환자야간평균수축압、야간평균서장압고우비야간고혈압조（P ﹤0.05）。A 조여 B 조환자치료전주간평균수축압、주간평균서장압、야간평균수축압、야간평균서장압비교，차이균무통계학의의（P ﹥0.05）。A 조여 B 조환자치료후주간평균수축압、주간평균서장압비교，차이균무통계학의의（P ﹥0.05）；B 조환자치료후야간평균수축압、야간평균서장압저우 A 조（P ﹤0.05）。A 조여 B 조환자치료전혈압변이성비교，차이무통계학의의（P ﹥0.05）；치료후 B 조환자혈압변이성우우 A 조（P ﹤0.05）。결론여비야간고혈압환자상비，야간고혈압환자림상표현무특이성，주요이야간혈압승고위주，방만가복비락지평완석편가유효제고야간고혈압환자치료효과，우화혈압주야절률。
Objective To analyze the clinical features and treatment of patients with nocturnal hypertension. Methods From September 2013 to September 2014,a total of 200 outpatients and inpatients with hypertension stage at Ⅲ were selected in the Department of Cardiology,Beijing Yanhua Hospital,and they were divided into case group( with nocturnal hypertension)and control group(without nocturnal hypertension)according to 24 - hour ambulatory blood pressure monitoring results,each of 100 cases;of case group,patients were divided into two subgroups according to medication frequency:bases on <br> non - medicine treatment, patients of A group received felodipin sustained - release tablets ( 10 mg ) and benazepril hydrochloride(10 mg) in the morning;patients of B group received felodipin sustained - release tablets ( 5 mg) and benazepril hydrochloride(10 mg)in the morning,felodipin sustained - release tablets(5 mg)at 17:00. The clinical features were compared between case group and control group,treatment outcome and blood pressure variability before and after treatment were compared between A group and B group. Results No statistically significant differences of gender,age,course of hypertension,complications,daytime mean systolic blood pressure,daytime mean diastolic blood pressure or proportion of non- dipper blood pressure was found between case group and control group(P ﹥ 0. 05);nighttime mean systolic blood pressure and nighttime mean diastolic blood pressure of case group were statistically significantly lower than those of control group(P ﹤0. 05). No statistically significant differences of daytime mean systolic blood pressure,daytime mean diastolic blood pressure, nighttime mean systolic blood pressure or nighttime mean diastolic blood pressure was found between A group and B group before treatment(P ﹥ 0. 05). After treatment,no statistically significant differences of daytime mean systolic blood pressure or daytime mean diastolic blood pressure was found between A group and B group(P ﹥ 0. 05);nighttime mean systolic blood pressure and nighttime mean diastolic blood pressure of B group were statistically significantly lower than those of A group(P ﹤ 0. 05). No statistically significant differences of blood pressure variability was found between A group and B group before treatment( P ﹥0. 05);while blood pressure variability of B group was statistically significantly better than that of A group after treatment(P ﹤0. 05). Conclusion Compared with simple hypertension patients,clinical features of patients with nocturnal hypertension are non - specific,most of them performed as daytime blood pressure elevated;taking felodipin sustained - release tablets in the evening can effectively improve the treatment outcome and circadian rhythm of blood pressure.
