CAJ | 학술논문

目的：比较哌罗匹隆与氟哌啶醇治疗老年精神分裂症患者的临床疗效及安全性。方法选取攀枝花市第三人民医院2012—2014年收治的精神分裂症患者64例，按照随机数字表法分为试验组和对照组，每组32例。试验组患者给予哌罗匹隆治疗，对照组患者给予氟哌啶醇治疗。比较两组患者临床疗效及不良反应发生情况，治疗前及治疗4、6、8周阳性与阴性症状量表（PANSS）评分，并观察两组患者合并用药情况。结果64例患者中完成研究者62例，两组各有1例患者因依从性差而脱落。两组患者临床疗效比较，差异无统计学意义（u =-0.049，P =0.961）。治疗前及治疗4、6、8周两组患者阴性症状量表评分、阳性症状量表评分、一般精神病理症状量表评分及 PANSS 总分比较，差异无统计学意义（P ﹥0.05）；治疗4周两组患者阳性症状量表评分、一般精神病理症状量表评分及 PANSS 总分均低于治疗前，治疗6、8周两组患者阴性症状量表评分、阳性症状量表评分、一般精神病理症状量表评分及 PANSS总分均低于治疗前（P ﹤0.05）。试验组患者锥体外系反应发生率低于对照组（P ﹤0.05）；两组患者嗜睡、记忆力下降、恶心呕吐、心率加快、失眠、视物模糊、头晕、便秘发生率比较，差异无统计学意义（P ﹥0.05）。试验组4例、对照组3例患者因失眠导致焦虑、紧张而使用苯二氮卓艹类药物，均未使用抗胆碱能药物。结论哌罗匹隆与氟哌啶醇治疗老年精神分裂症的临床疗效相当，但哌罗匹隆引起的锥体外系反应发生率较低，患者依从性更好。
목적：비교고라필륭여불고정순치료노년정신분렬증환자적림상료효급안전성。방법선취반지화시제삼인민의원2012—2014년수치적정신분렬증환자64례，안조수궤수자표법분위시험조화대조조，매조32례。시험조환자급여고라필륭치료，대조조환자급여불고정순치료。비교량조환자림상료효급불량반응발생정황，치료전급치료4、6、8주양성여음성증상량표（PANSS）평분，병관찰량조환자합병용약정황。결과64례환자중완성연구자62례，량조각유1례환자인의종성차이탈락。량조환자림상료효비교，차이무통계학의의（u =-0.049，P =0.961）。치료전급치료4、6、8주량조환자음성증상량표평분、양성증상량표평분、일반정신병리증상량표평분급 PANSS 총분비교，차이무통계학의의（P ﹥0.05）；치료4주량조환자양성증상량표평분、일반정신병리증상량표평분급 PANSS 총분균저우치료전，치료6、8주량조환자음성증상량표평분、양성증상량표평분、일반정신병리증상량표평분급 PANSS총분균저우치료전（P ﹤0.05）。시험조환자추체외계반응발생솔저우대조조（P ﹤0.05）；량조환자기수、기억력하강、악심구토、심솔가쾌、실면、시물모호、두훈、편비발생솔비교，차이무통계학의의（P ﹥0.05）。시험조4례、대조조3례환자인실면도치초필、긴장이사용분이담탁초류약물，균미사용항담감능약물。결론고라필륭여불고정순치료노년정신분렬증적림상료효상당，단고라필륭인기적추체외계반응발생솔교저，환자의종성경호。
Objective To compare the clinical effect and safety on senile schizophrenia between perospirone and haloperidol. Methods A total of 62 aged patients with schizophrenics were selected in the Third People's Hospital of Panzhihua from 2012 to 2014,and they were divided into control group and test group,each of 32 cases. Patients of control group received haloperidol,while patients of test group received perospirone. Clinical effect,incidence of adverse reactions,PANSS score before treatment and 4,6,8 weeks of treatment were compared between the two groups,and drug combination was observed. Results One of control group and one of test group lost caused by poor compliance. No statistically significant differences of clinical effect was found between the two group(u = - 0. 049,P = 0. 961). No statistically significant differences of Negative Symptoms Rating Scale score,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score or total PANSS score was found between the two groups before treatment or 4,6,8 weeks of treatment(P ﹥ 0. 05);after 4 weeks of treatment,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score and total PANSS score of both groups were statistically significantly lower than those before treatment( P ﹤ 0. 05);after 6 and 8 weeks of treatment, Negative Symptoms Rating Scale score,Positive Symptoms Rating Scale score,General Mental Pathological Symptoms Scale score and total PANSS score of both groups were statistically significantly lower than those before treatment(P ﹤ 0. 05). The incidence of extrapyramidal reactions of test group was statistically significantly lower than that of control group( P ﹤ 0. 05),while no statistically significant differences of incidence of sleepiness,memory deterioration,nausea and vomiting,increased heart rate, insomnia,blurred vision,dizziness orconstipation was found between the two groups(P ﹥ 0. 05). Three cases of control group, four cases of test group used benzodiazepines because of insomnia - induced anxiety and tension, but no one used anticholinergics. Conclusion Perospirone has similar clinical effect in treating senile schizophrenia with haloperidol,but the incidence of perospirone - induced extrapyramidal reactions is relatively low,and the patients'compliance is better.