CAJ | 학술논문

目的:探讨非糖尿病人群载脂蛋白(Apo)A/B及其相关脂质指标与冠状动脉病变的关系.方法:选取2014年在笔者所在医院行冠脉造影术的352例患者,根据冠状动脉造影结果将其分为对照组、冠状动脉粥样硬化组及冠心病组.比较三组的总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、ApoA、ApoB、ApoA/B,分析脂质指标与代表冠状动脉病变程度的Gensini积分的关系.结果:三组在性别、年龄、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、ApoA方面比较,差异均无统计学意义(P>0.05),冠状动脉粥样硬化组的ApoB较对照组升高,差异有统计学意义(P<0.05),ApoA/B较对照组下降,差异有统计学意义(P<0.01).冠心病组的LDL-C、ApoB、ApoA/B与对照组比较,差异均有统计学意义(P<0.01).Gensini积分与ApoA、ApoA/B呈负相关,与LDL-C、ApoB呈正相关.结论:本研究显示非糖尿病人群ApoA/B和冠状动脉病变严重程度呈负相关.
목적:탐토비당뇨병인군재지단백(Apo)A/B급기상관지질지표여관상동맥병변적관계.방법:선취2014년재필자소재의원행관맥조영술적352례환자,근거관상동맥조영결과장기분위대조조、관상동맥죽양경화조급관심병조.비교삼조적총담고순、감유삼지、고밀도지단백담고순、저밀도지단백담고순、ApoA、ApoB、ApoA/B,분석지질지표여대표관상동맥병변정도적Gensini적분적관계.결과:삼조재성별、년령、총담고순、감유삼지、고밀도지단백담고순、ApoA방면비교,차이균무통계학의의(P>0.05),관상동맥죽양경화조적ApoB교대조조승고,차이유통계학의의(P<0.05),ApoA/B교대조조하강,차이유통계학의의(P<0.01).관심병조적LDL-C、ApoB、ApoA/B여대조조비교,차이균유통계학의의(P<0.01).Gensini적분여ApoA、ApoA/B정부상관,여LDL-C、ApoB정정상관.결론:본연구현시비당뇨병인군ApoA/B화관상동맥병변엄중정도정부상관.
Objective:To investigate the relationship between apolipoprotein (Apo) A/B and its related lipid associated indicators and the coronary artery lesions in non-diabetic population.Method:352 patients were selected in our hospital in 2014,according to the coronary angiography results, they were divided into the control group,the coronary atherosclerosis group and the coronary heart disease group.The total cholesterol(TC),triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), ApoA, ApoB and ApoA/B of the three groups were compared,the relationship between lipid parameters and on behalf of the coronary artery lesion severity Gensini score was analyzed.Result:There were no significance in gender, age, TC, TG, HDL-C and ApoA between the three groups.ApoB of the coronary atherosclerosis group was higher than that the control group ,the difference was statistically significant(P<0.05); and ApoA/B was decreased,there was statistically significant difference (P<0.01);LDL-C,ApoB,ApoA/B of the coronary atherosclerosis group were higher than those of the control group ,the differences were statistically significant (P<0.01).Gensini score was negatively correlated with the ApoA and ApoA/B, and positively correlated with LDL-C and ApoB.Conclusion:This research shows that ApoA/B is negatively correlated with the severity of coronary lesions in non-diabetic population.