当代化工
噹代化工
당대화공
Contemporary Chemical Industry
2015年
11期
2729-2732
,共4页
保健食品%非法添加%MRM%快速筛查
保健食品%非法添加%MRM%快速篩查
보건식품%비법첨가%MRM%쾌속사사
Healthy food%Illegally added%MRM%Rapid screening
建立高效液相色谱法及串联质谱法同时测定补肾壮阳类保健食品中非法添加11种化药成分。采用高效液相色谱法考察线性关系、精密度、稳定性以及回收率。采用 scan、sim 及 product ion 的扫描方式对11种化合物进行质谱条件的优化。结果11种化药成分峰面积与浓度之间线性关系良好（r≥0.9999），各组分回收率在96.8%~100.5%之间，稳定性、精密度良好。采用优化后的质谱参数试验，各组份分离度良好，MRM 方式准确快速。结论该法准确快速，适用于补肾壮阳类保健食品非法添加的定性、定量测定以及快速筛查工作。
建立高效液相色譜法及串聯質譜法同時測定補腎壯暘類保健食品中非法添加11種化藥成分。採用高效液相色譜法攷察線性關繫、精密度、穩定性以及迴收率。採用 scan、sim 及 product ion 的掃描方式對11種化閤物進行質譜條件的優化。結果11種化藥成分峰麵積與濃度之間線性關繫良好（r≥0.9999），各組分迴收率在96.8%~100.5%之間，穩定性、精密度良好。採用優化後的質譜參數試驗，各組份分離度良好，MRM 方式準確快速。結論該法準確快速，適用于補腎壯暘類保健食品非法添加的定性、定量測定以及快速篩查工作。
건립고효액상색보법급천련질보법동시측정보신장양류보건식품중비법첨가11충화약성분。채용고효액상색보법고찰선성관계、정밀도、은정성이급회수솔。채용 scan、sim 급 product ion 적소묘방식대11충화합물진행질보조건적우화。결과11충화약성분봉면적여농도지간선성관계량호（r≥0.9999），각조분회수솔재96.8%~100.5%지간，은정성、정밀도량호。채용우화후적질보삼수시험，각조빈분리도량호，MRM 방식준학쾌속。결론해법준학쾌속，괄용우보신장양류보건식품비법첨가적정성、정량측정이급쾌속사사공작。
A method was established to determine 11 kinds of compositions illegally added in kidney healthy food by HPLC-MS/MS. HPLC was used to investigate the linear relationship, precision, stability and recovery rate. Scan, sim and product ion methods were used to optimize the MS parameters. The results show that the linear relationship, precision and stability are good(r≥0.999 9. The recovery rate of each group is 96.8%~100.5%. The separation of each group is good, and the MRM is accurate and fast. The method is suitable for qualitative and quantitative determination and rapid screening of the 11 kinds of compositions in kidney healthy food.
