CAJ | 학술논문

目的：对照研究帕利哌酮缓释片对精神分裂症的疗效以及安全性。方法选取某院2014年2月至2015年2月收治的46例精神分裂症患者作为研究对象。按照收治顺序将其随机分为对照组和实验组各23例。对照组患者采用利培酮进行治疗，实验组患者采用帕利哌酮缓释片进行治疗。对比基线、治疗2周后与治疗4周后两组患者的阳性和阴性症状，以及一般精神病理。结果在治疗2周与4周后，实验组患者的阳性症状、阴性症状以及一般精神病理均低于基线时和对照组，差异具有统计学意义(P<0.05)。同时，实验组与对照组均未出现严重的不良反应事件。结论帕利哌酮缓释片对于精神分裂症患者的阳性症状、阴性症状、一般精神病理能够起到明显的改善作用。
목적：대조연구파리고동완석편대정신분렬증적료효이급안전성。방법선취모원2014년2월지2015년2월수치적46례정신분렬증환자작위연구대상。안조수치순서장기수궤분위대조조화실험조각23례。대조조환자채용리배동진행치료，실험조환자채용파리고동완석편진행치료。대비기선、치료2주후여치료4주후량조환자적양성화음성증상，이급일반정신병리。결과재치료2주여4주후，실험조환자적양성증상、음성증상이급일반정신병리균저우기선시화대조조，차이구유통계학의의(P<0.05)。동시，실험조여대조조균미출현엄중적불량반응사건。결론파리고동완석편대우정신분렬증환자적양성증상、음성증상、일반정신병리능구기도명현적개선작용。
ObjectiveTo take a control study on the efficacy andsafety of Paley risperidone sustained-release tablets in the treatment of schizophrenia.Methods 46 cases of schizophrenia patients from Feb.2014 to Feb.2014 are selected and randomly divided into the control group and the experimental group according to the treatment order. Control group were treated by risperidone treatment and the experimental group were treated by Paley risperidone sustained-release tablets for treatment. Compare the baseline, the positive and negative symptomstreatment and general psychopathology of the two groups after 2 weeks and 4 weeks after treatment. Results After treatment for 2 weeks and 4 weeks, the positive symptoms, negative symptoms and general psychopathology of experiment group are lower than the baseline and the control group, whichdifference has statistical significance (P<0.05). And the experimental group and control group has no serious adverse events occurred. Conclusion Paley risperidone sustained-release tablets can obviously improve the positive symptoms, negative symptoms, general psychopathology of schizophrenia patients.