CAJ | 학술논문

目的：比较伴与不伴焦虑症状抑郁症患者的自杀风险，分析抑郁症患者自杀风险的危险因素。方法：对2010年9月1日至2011年2月28日“中国双相情感障碍患者诊断评估服务”研究项目的数据进行二次分析，纳入分析的抑郁症患者共1172例，根据简明国际神经精神访谈（M. I. N. I）焦虑模块，分为伴焦虑症状抑郁症组728例（62.1％）及不伴焦虑症状组444例（37.9％）。采用M. I. N. I自杀模块评估自杀风险，比较伴与不伴焦虑症状抑郁症患者的自杀风险，通过logistic回归分析探讨抑郁症患者自杀风险的相关因素。结果：伴焦虑症状抑郁症患者中有自杀风险者331例（45.5％）；不伴焦虑症状者中有自杀风险者54例（12.2％）。与不伴焦虑症状抑郁症患者比较，伴焦虑症状者自杀风险更高（P＜0.001）。Logistic回归分析显示，抑郁发作频繁（OR＝2.07）、伴精神病性症状（OR＝2.01）、伴焦虑症状（OR＝3.18）、伴忧郁型特征（OR＝2.90）与抑郁症患者的自杀风险相关。结论：伴焦虑症状抑郁症患者可能有更高的自杀风险。发作频繁、伴精神病性症状、伴焦虑症状或伴忧郁型特征可能是抑郁症患者自杀风险的危险因素。
목적：비교반여불반초필증상억욱증환자적자살풍험，분석억욱증환자자살풍험적위험인소。방법：대2010년9월1일지2011년2월28일“중국쌍상정감장애환자진단평고복무”연구항목적수거진행이차분석，납입분석적억욱증환자공1172례，근거간명국제신경정신방담（M. I. N. I）초필모괴，분위반초필증상억욱증조728례（62.1％）급불반초필증상조444례（37.9％）。채용M. I. N. I자살모괴평고자살풍험，비교반여불반초필증상억욱증환자적자살풍험，통과logistic회귀분석탐토억욱증환자자살풍험적상관인소。결과：반초필증상억욱증환자중유자살풍험자331례（45.5％）；불반초필증상자중유자살풍험자54례（12.2％）。여불반초필증상억욱증환자비교，반초필증상자자살풍험경고（P＜0.001）。Logistic회귀분석현시，억욱발작빈번（OR＝2.07）、반정신병성증상（OR＝2.01）、반초필증상（OR＝3.18）、반우욱형특정（OR＝2.90）여억욱증환자적자살풍험상관。결론：반초필증상억욱증환자가능유경고적자살풍험。발작빈번、반정신병성증상、반초필증상혹반우욱형특정가능시억욱증환자자살풍험적위험인소。
Objective:To compare the suicidality risk in major depressive disorder (MDD)patients with and without anxious characteristics,and analyze the risk factors of suicidality in MDD patients. Methods:This was a secondary analysis of the data from the Diagnostic Assessment Service for people with Bipolar Disorders in China (DASP),which was initiated by the Chinese Society of Psychiatry (CSP),from September 1,2010 to February 28, 201 1. Based on the anxious module and suicide module of Mini International Neuropsychiatric Interview (M. I. N. I),1 172 MDD patients were classified as suffering from anxious MDD (n=728,62. 1%)and non-anxious MDD(n=444,37. 9%). Logistic regression was employed to examine the risk factors of suicidality in MDD pa-tients. Results:Among the anxious MDD patients,331 (45. 5%)of them had suicidality risk. And 54(12. 2%)of non-anxious MDD patients had suicidality risk. Compare to the non-anxious group,the anxious MDD patients had significantly higher suicidality risk (P<0. 00 1 ). Logistic regression analysis showed that more frequent depressive episodes (OR=2. 07 ),depressive episodes with psychotic symptoms (OR=2. 0 1 ),comorbid with anxious charac-teristics (OR=3. 18)or melancholic characteristics (OR=2. 90)were associated with suicidality risk in patients with MDD. Conclusion:It indicates that the anxious MDD patients may have higher suicidality risk than non-anx-ious MDD patients,and more frequent depressive episodes,depressive episodes with psychotic symptoms,comorbid with anxious characteristics or melancholic characteristics may be risk factors of suicidality in patients with MDD.