现代仪器与医疗
現代儀器與醫療
현대의기여의료
Modern Instruments & Mediccal Treatment
2015年
6期
13-15
,共3页
铁蛋白%尿中性粒细胞明胶酶相关性脂质运载蛋白%系统性红斑狼疮%疾病活动度
鐵蛋白%尿中性粒細胞明膠酶相關性脂質運載蛋白%繫統性紅斑狼瘡%疾病活動度
철단백%뇨중성립세포명효매상관성지질운재단백%계통성홍반랑창%질병활동도
Ferritin%NGAL%Systemic lupus erythematosus%Disease activity
目的：分析血清铁蛋白（Ferritin，FET）、尿中性粒细胞明胶酶相关性脂质运载蛋白（NGAL）水平与系统性红斑狼疮（Systemic lupus erythematosus，SLE）疾病活动度关系。方法：选取我院2012年6月至2015年6月收治的91例S L E患者及同期40例健康体检者，分别纳入患者组与正常组。按照S L E患者疾病活动度分为稳定期组（n=47）及活动期组（n=44），检测各组FET、ds-DNA抗体及NGAL水平。结果：活动期组血清FET、ds-DNA抗体、NGAL水平显著高于稳定期组、正常组，稳定期组血清FET、ds-DNA抗体水平显著高于正常组，差异有统计学意义（P＜0.05），稳定期组与正常组N G A L水平比较，差异无统计学意义（P＞0.05）。稳定期组血清F E T异常率为40.43%，显著低于活动期组的88.63%，差异有统计学意义（P＜0.05）。血清FET与ds-DNA抗体、NGAL水平及SLEDAI均呈正相关（P＜0.05）。结论：血清FET、NGAL水平与SLE患者疾病活动度有着密切关联，能够有效指导SLE的实验室诊断及病情监测。
目的：分析血清鐵蛋白（Ferritin，FET）、尿中性粒細胞明膠酶相關性脂質運載蛋白（NGAL）水平與繫統性紅斑狼瘡（Systemic lupus erythematosus，SLE）疾病活動度關繫。方法：選取我院2012年6月至2015年6月收治的91例S L E患者及同期40例健康體檢者，分彆納入患者組與正常組。按照S L E患者疾病活動度分為穩定期組（n=47）及活動期組（n=44），檢測各組FET、ds-DNA抗體及NGAL水平。結果：活動期組血清FET、ds-DNA抗體、NGAL水平顯著高于穩定期組、正常組，穩定期組血清FET、ds-DNA抗體水平顯著高于正常組，差異有統計學意義（P＜0.05），穩定期組與正常組N G A L水平比較，差異無統計學意義（P＞0.05）。穩定期組血清F E T異常率為40.43%，顯著低于活動期組的88.63%，差異有統計學意義（P＜0.05）。血清FET與ds-DNA抗體、NGAL水平及SLEDAI均呈正相關（P＜0.05）。結論：血清FET、NGAL水平與SLE患者疾病活動度有著密切關聯，能夠有效指導SLE的實驗室診斷及病情鑑測。
목적：분석혈청철단백（Ferritin，FET）、뇨중성립세포명효매상관성지질운재단백（NGAL）수평여계통성홍반랑창（Systemic lupus erythematosus，SLE）질병활동도관계。방법：선취아원2012년6월지2015년6월수치적91례S L E환자급동기40례건강체검자，분별납입환자조여정상조。안조S L E환자질병활동도분위은정기조（n=47）급활동기조（n=44），검측각조FET、ds-DNA항체급NGAL수평。결과：활동기조혈청FET、ds-DNA항체、NGAL수평현저고우은정기조、정상조，은정기조혈청FET、ds-DNA항체수평현저고우정상조，차이유통계학의의（P＜0.05），은정기조여정상조N G A L수평비교，차이무통계학의의（P＞0.05）。은정기조혈청F E T이상솔위40.43%，현저저우활동기조적88.63%，차이유통계학의의（P＜0.05）。혈청FET여ds-DNA항체、NGAL수평급SLEDAI균정정상관（P＜0.05）。결론：혈청FET、NGAL수평여SLE환자질병활동도유착밀절관련，능구유효지도SLE적실험실진단급병정감측。
Objective: To analyze the relationship between FET level and NGAL level with the disease activity of Systemic lupus erythematosus. Methods: 91 patients with SLE in our hospital from June 2012 to June 2015 were selected, and 40 cases of healthy persons in the same period were included. They were included in the patient group and normal group. According to the disease activity of SLE patients, they were divided into the stable phase group (n=47) and the active phase group (n=44). Detected FET,ds-DNA and NGAL. Results:The levels of serum FET, NGAL and ds-DNA were signiifcantly higher in the active stage group than in the stable phase group and the normal group, the levels of serum FET and ds-DNA in the stable phase group were signiifcantly higher than those in the normal group (P<0.05), the difference was not statistically signiifcant (P > 0.05). The abnormal rate of FET in the stable stage group was 40.43%, which was signiifcantly lower than that in the active stage group(88.63) (P<0.05). The levels of serum FET were positively correlated with ds-DNA, NGAL and SLEDAI (P < 0.05). Conclusions: Serum FET level and NGAL level are closely related to the disease activity of patients with SLE, which can effectively guide the laboratory diagnosis and monitoring.
