CAJ | 학술논문

目的调查水源性高碘地区6～ 12岁儿童的水碘、尿碘及甲状腺容积,了解甲状腺容积与水碘、尿碘含量及年龄之间的关系.方法 2011年7月至2012年3月,在山东、山西、河北、河南4个省,将水碘划分为50～99、100～ 149、150 ～299、≥300 μg/L4个水平,每个水碘水平选择3个村作为调查村;在调查村的村小学采集全部6～ 12岁儿童所在家庭的食用盐检测盐碘;剔除食用盐为碘盐的儿童,检测剩余儿童饮水碘含量,并进行甲状腺容积和尿碘测定,分析甲状腺容积与水碘、尿碘及年龄之间的关系.盐碘检测采用半定量法,尿碘检测采用砷铈催化分光光度法,甲状腺容积检测采用B超法.结果 6～ 12岁各年龄组儿童甲状腺容积的中位数分别为2.00、2.21、2.54、2.94、3.30、3.44、3.72 ml;尿碘中位数分别为252.3、319.4、345.2、350.9、371.2、384.4、409.6 μg/L.水碘＞100 μg/L时,除水碘100 ～ 149μg/L组6岁儿童尿碘中位数为274.0 μg/L外,其余各年龄组儿童尿碘中位数均＞ 300μg/L.水碘、尿碘、年龄均与甲状腺容积呈正相关[相关系数(r)=0.154、0.148、0.381,P均＜0.01];水碘与尿碘呈明显正相关(r=0.399,P＜0.05).同一水碘水平,不同年龄儿童的尿碘和甲状腺容积,随年龄增加而越来越分散,表现出对高碘的个体化反应差异.结论在水源性高碘地区,尽管食用不加碘食盐,仍有儿童处于碘过量的状态,甲状腺容积与水碘、尿碘有关.
목적 조사수원성고전지구6～ 12세인동적수전、뇨전급갑상선용적,료해갑상선용적여수전、뇨전함량급년령지간적관계.방법 2011년7월지2012년3월,재산동、산서、하북、하남4개성,장수전화분위50～99、100～ 149、150 ～299、≥300 μg/L4개수평,매개수전수평선택3개촌작위조사촌;재조사촌적촌소학채집전부6～ 12세인동소재가정적식용염검측염전;척제식용염위전염적인동,검측잉여인동음수전함량,병진행갑상선용적화뇨전측정,분석갑상선용적여수전、뇨전급년령지간적관계.염전검측채용반정량법,뇨전검측채용신시최화분광광도법,갑상선용적검측채용B초법.결과 6～ 12세각년령조인동갑상선용적적중위수분별위2.00、2.21、2.54、2.94、3.30、3.44、3.72 ml;뇨전중위수분별위252.3、319.4、345.2、350.9、371.2、384.4、409.6 μg/L.수전＞100 μg/L시,제수전100 ～ 149μg/L조6세인동뇨전중위수위274.0 μg/L외,기여각년령조인동뇨전중위수균＞ 300μg/L.수전、뇨전、년령균여갑상선용적정정상관[상관계수(r)=0.154、0.148、0.381,P균＜0.01];수전여뇨전정명현정상관(r=0.399,P＜0.05).동일수전수평,불동년령인동적뇨전화갑상선용적,수년령증가이월래월분산,표현출대고전적개체화반응차이.결론 재수원성고전지구,진관식용불가전식염,잉유인동처우전과량적상태,갑상선용적여수전、뇨전유관.
Objective To detect water iodine content,urinary iodine content and thyroid volume of children aged 6-12 in high water-iodine areas and to explore the relationship between thyroid volume and the three factors (water iodine content,urinary iodine content and age).Methods In July 2011 to March 2012,four provinces of Shandong,Shanxi,Henan and Hebei were investigated,and water iodine content were divided into 4 levels,which were 50-99,100-149,150-299,and ≥300 μg/L,respectively.For each water iodine content level,three villages were analyzed.School children aged 6-12 were recruited,family salt iodine was determined to exclude those children who had intaken iodized salt.After that,water iodine content,urinary iodine content and thyroid volume of children were measured.Finally,relationships between thyroid volume and water iodine content,urinary iodine content and age were analyzed.Salt iodine was detected by semi-quantitative method;urinary iodine was detected by arsenic cerium catalytic spectrophotometry;thyroid volume was detected by B-scan ultrasonography.Results The medians of thyroid volume in each age group from 6 to 12 years were 2.00,2.21,2.54,2.94,3.30,3.44,and 3.72 ml,respectively;the medians of urinary iodine content in each age group were 252.3,319.4,345.2,350.9,371.2,384.4,and 409.6 μg/L,respectively.Under the condition of water iodine content ＞ 100 μg/L,the median of urinary iodine content of children aged 6 in 100-149 μg/L water iodine content group was 274.0 μg/L,while other groups with different ages got the median of urinary iodine content more than 300 μg/L.Water iodine content,urinary iodine content and age were all positively correlated with thyroid volume (r =0.154,0.148,0.381,all P ＜ 0.01).In addition,water iodine content and urinary iodine content were positively correlated (r =0.399,P ＜ 0.05).With the same water iodine content level,the urinary iodine content and thyroid volume showed a significant dispersion with increasing age,which meant different individual responses to higher iodine.Conclusions In higher water-iodine areas,the iodine level of children is excessive,although they have intaken non-iodized salt.Furthermore,thyroid volume is associated with water iodine content,urinary iodine content and age.