CAJ | 학술논문

目的探讨内蒙古呼和浩特市女性甲状腺肿瘤发病的主要危险因素,为女性甲状腺肿瘤的预防和治疗提供科学依据.方法采用病例对照的研究方法,选取2010年3月至2011年9月在内蒙古医学院附属医院和内蒙古自治区医院住院手术且病理检查确诊的女性甲状腺肿瘤患者190例,作为病例组.同时,选取同时期、同医院住院且排除相关疾病(甲状腺其他疾病,内分泌系统疾病,其他肿瘤及肝、肾功能不全等)的患者190例,作为对照组.使用统一编制的调查表,主要内容包括:一般因素、行为和习惯因素、女性生理和生育因素、职业和生活接触因素、个人疾病因素、药物因素、家族因素等.由经过专门培训的调查人员以面访形式对病例组和对照组进行问卷调查,并由超声科及病理科等专业医生进行相应的体格检查和辅助检查.采用SPSS17.0统计学软件,通过Logistic回归分析各因素与女性甲状腺肿瘤的关系,寻找与内蒙古呼和浩特市女性甲状腺肿瘤发病密切相关的主要危险因素.结果 Logistic回归分析结果显示,初孕高龄、体质指数大、腌制食物和鱼虾海带等海产品食用过多、文化程度高、经历负性生活事件与女性甲状腺肿瘤的发病呈显著正相关[比值比(OR)=1.527、22.729、2.271、4.303、1.117、1.489,P均＜0.05].结论内蒙古呼和浩特市女性甲状腺肿瘤的发病是多因素相互综合作用的结果.初次怀孕的年龄高、体质指数大、食用较多的腌制食物和鱼虾海带等海产品、经历负性生活事件以及文化程度高可能为甲状腺肿瘤发病的主要危险因素.
목적 탐토내몽고호화호특시녀성갑상선종류발병적주요위험인소,위녀성갑상선종류적예방화치료제공과학의거.방법 채용병례대조적연구방법,선취2010년3월지2011년9월재내몽고의학원부속의원화내몽고자치구의원주원수술차병리검사학진적녀성갑상선종류환자190례,작위병례조.동시,선취동시기、동의원주원차배제상관질병(갑상선기타질병,내분비계통질병,기타종류급간、신공능불전등)적환자190례,작위대조조.사용통일편제적조사표,주요내용포괄:일반인소、행위화습관인소、녀성생리화생육인소、직업화생활접촉인소、개인질병인소、약물인소、가족인소등.유경과전문배훈적조사인원이면방형식대병례조화대조조진행문권조사,병유초성과급병이과등전업의생진행상응적체격검사화보조검사.채용SPSS17.0통계학연건,통과Logistic회귀분석각인소여녀성갑상선종류적관계,심조여내몽고호화호특시녀성갑상선종류발병밀절상관적주요위험인소.결과 Logistic회귀분석결과현시,초잉고령、체질지수대、업제식물화어하해대등해산품식용과다、문화정도고、경력부성생활사건여녀성갑상선종류적발병정현저정상관[비치비(OR)=1.527、22.729、2.271、4.303、1.117、1.489,P균＜0.05].결론 내몽고호화호특시녀성갑상선종류적발병시다인소상호종합작용적결과.초차부잉적년령고、체질지수대、식용교다적업제식물화어하해대등해산품、경력부성생활사건이급문화정도고가능위갑상선종류발병적주요위험인소.
Objective To study the major risk factors for female thyroid tumor in Hohhot of Inner Mongolia and to provide a scientific basis for prevention and treatment of the disease.Methods A case control study was carried out,190 female patients who had suffered thyroid tumor and had been operated on in the Affiliated Hospital of Inner Mongoha Medical College and Inner Mongolia Hospital from March 2010 to September 2011 were selected.Meanwhile,190 female patients who were excluded from being suffering this disease were chosen as controls.A formal questionnaire was made,including the following contents:the general situation,the life style and behavior habit,women's physiological and reproductive situation,job and life factors,personal disease,and medicine and genetic factors.Then,trained investigators who had at least got the bachelor degree interviewed all the patients in the two groups and the doctors in the office of ultrasound and pathology made the check-up.All data made up a database;statistical description and analysis was done with software SPSS 17.0.Through Logistic regression analysis,the relationship between all factors and female thyroid tumor was analyzed in order to find major risk factors related to female thyroid tumor in Hohhot.Results The results of Logistic regression analysis showed that the delay of the first pregnancy,the higher Body Mass Index,too much preserved food and seafood in the diet,higher level of education,negative live event were apparently related to female thyroid tumor (OR =1.527,22.729,2.271,4.303,1.117,1.489,all P ＜ 0.05).Conclusions The female thyroid tumor in Hohhot is a result of comprehensive effect of multiple factors.This study found that the delay of the first pregnancy,the higher Body Mass Index,too much preserved food and seafood in the diet,higher level of education,and negative live event are apparently related to female thyroid tumor,and these factors may be major risk factors for thyroid tumor based on the current epidemiological study.