CAJ | 학술논문

目的：分析比较二甲双胍联合TC方案和单纯TC方案在伴有糖尿病的中老年晚期卵巢癌患者术后辅助化疗中的临床疗效。方法60例伴有糖尿病的中老年晚期卵巢癌患者，均用胰岛素控制血糖良好，随机分为治疗组和对照组，每组30例，治疗组采用二甲双胍联合TC方案治疗，对照组采用TC方案治疗。两组患者治疗均以21 d为1个周期。至少完成2周期化疗的患者进行疗效、毒副反应评价。结果治疗组的临床疗效优于对照组，治疗组有效28例（93．3％）；对照组有效19例（63．3％）。两组比较，差异具有统计学意义（ P＜0．05）。两组的副反应相比，差异无统计学意义（ P＞0．05）。结论采用二甲双胍联合TC方案治疗伴糖尿病的中老年人晚期卵巢癌的临床疗效确切，不良反应并未明显增加，值得在临床推广应用。
목적：분석비교이갑쌍고연합TC방안화단순TC방안재반유당뇨병적중노년만기란소암환자술후보조화료중적림상료효。방법60례반유당뇨병적중노년만기란소암환자，균용이도소공제혈당량호，수궤분위치료조화대조조，매조30례，치료조채용이갑쌍고연합TC방안치료，대조조채용TC방안치료。량조환자치료균이21 d위1개주기。지소완성2주기화료적환자진행료효、독부반응평개。결과치료조적림상료효우우대조조，치료조유효28례（93．3％）；대조조유효19례（63．3％）。량조비교，차이구유통계학의의（ P＜0．05）。량조적부반응상비，차이무통계학의의（ P＞0．05）。결론채용이갑쌍고연합TC방안치료반당뇨병적중노년인만기란소암적림상료효학절，불량반응병미명현증가，치득재림상추엄응용。
[ ABSTRACT ] Objective To compare the clinical effect in assistant chemotherapy of metformin united TC scheme and alone TC scheme in elderly patients suffering from advanced ovarian cancer and diabetes.Methods Sixty elderly patients suffering from advanced ovarian cancer and diabetes,all with insulin to control blood sugar well,random-ly were divided into treatment group and control group.The treatment group were treated with metformin united TC scheme,the control group with TC scheme only.Twenty-one days as a treatment cycle.the efficacy and side effects in pa-tients at least two cycles of chemotherapy were evaluated.Results The clinical efficacy of the treatment group is better than the control group.There are twenty-eight cases of effective in the treatment group and the effective rate is 93.3%. There are nineteen cases of effective in the control group and the effective rate is 63 .3%,the effective rate were statisti-cally significant(P<0.05).Theside effects were not statistically significant(P>0.05).Conclusion The clinical effi-cacy of treatment with metformin united TC program in elderly patients suffering from advanced ovarian cancer and diabe-tes is exact and the adverse effects did not significantly increase.It is worth promoting to apply in clinical practice.