国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
International Journal of Endocrinology and Metabolism
2015年
6期
374-377
,共4页
樊立娜%李鹏辉%王芳%王祯%张雪晴%耿杨
樊立娜%李鵬輝%王芳%王禎%張雪晴%耿楊
번립나%리붕휘%왕방%왕정%장설청%경양
糖尿病%糖尿病足%胱抑素C%同型半胱氨酸
糖尿病%糖尿病足%胱抑素C%同型半胱氨痠
당뇨병%당뇨병족%광억소C%동형반광안산
Diabetes mellitus%Diabetic foot%Cystain C%Homocysteine
目的 探讨糖尿病足患者胱抑素C、同型半胱氨酸水平的变化及糖尿病足的相关危险因素.方法 选择自2012年1月至2014年7月在保定市第三中心医院内、外科住院的糖尿病患者134例,根据糖尿病足诊断标准将所有患者分为糖尿病组(63例)和糖尿病足组(71例).分别测量HbA1c、肌酐、尿酸、血清胱抑素C、尿微量白蛋白及同型半胱氨酸水平,多因素Logistic回归分析糖尿病足的危险因素.结果 糖尿病足组同型半胱氨酸、胱抑素C及HbA1c均高于糖尿病组(t=2.37,-4.00,-2.96,P均＜0.05).多因素Logistic回归分析显示同型半胱氨酸、胱抑素C、HbA1c、吸烟、体重指数为独立的危险因素,优势比分别为1.095 (95％ CI:1.031～1.162)、5.695(95％ CI:2.270～14.291)、1.807(95％ CI: 1.285～ 2.541)、13.401(95％ CI: 4.297～41.792)、1.246(95％ CI:1.027～1.510),P均＜0.01.结论 糖尿病足患者同型半胱氨酸、胱抑素C、HbA1c水平升高.胱抑素C、同型半胱氨酸、HbA1c、吸烟是糖尿病足的独立危险因素.
目的 探討糖尿病足患者胱抑素C、同型半胱氨痠水平的變化及糖尿病足的相關危險因素.方法 選擇自2012年1月至2014年7月在保定市第三中心醫院內、外科住院的糖尿病患者134例,根據糖尿病足診斷標準將所有患者分為糖尿病組(63例)和糖尿病足組(71例).分彆測量HbA1c、肌酐、尿痠、血清胱抑素C、尿微量白蛋白及同型半胱氨痠水平,多因素Logistic迴歸分析糖尿病足的危險因素.結果 糖尿病足組同型半胱氨痠、胱抑素C及HbA1c均高于糖尿病組(t=2.37,-4.00,-2.96,P均＜0.05).多因素Logistic迴歸分析顯示同型半胱氨痠、胱抑素C、HbA1c、吸煙、體重指數為獨立的危險因素,優勢比分彆為1.095 (95％ CI:1.031～1.162)、5.695(95％ CI:2.270～14.291)、1.807(95％ CI: 1.285～ 2.541)、13.401(95％ CI: 4.297～41.792)、1.246(95％ CI:1.027～1.510),P均＜0.01.結論 糖尿病足患者同型半胱氨痠、胱抑素C、HbA1c水平升高.胱抑素C、同型半胱氨痠、HbA1c、吸煙是糖尿病足的獨立危險因素.
목적 탐토당뇨병족환자광억소C、동형반광안산수평적변화급당뇨병족적상관위험인소.방법 선택자2012년1월지2014년7월재보정시제삼중심의원내、외과주원적당뇨병환자134례,근거당뇨병족진단표준장소유환자분위당뇨병조(63례)화당뇨병족조(71례).분별측량HbA1c、기항、뇨산、혈청광억소C、뇨미량백단백급동형반광안산수평,다인소Logistic회귀분석당뇨병족적위험인소.결과 당뇨병족조동형반광안산、광억소C급HbA1c균고우당뇨병조(t=2.37,-4.00,-2.96,P균＜0.05).다인소Logistic회귀분석현시동형반광안산、광억소C、HbA1c、흡연、체중지수위독립적위험인소,우세비분별위1.095 (95％ CI:1.031～1.162)、5.695(95％ CI:2.270～14.291)、1.807(95％ CI: 1.285～ 2.541)、13.401(95％ CI: 4.297～41.792)、1.246(95％ CI:1.027～1.510),P균＜0.01.결론 당뇨병족환자동형반광안산、광억소C、HbA1c수평승고.광억소C、동형반광안산、HbA1c、흡연시당뇨병족적독립위험인소.
Objective To investigate the serum level of homocysteine and cystatin C in patients with diabetic foot,and the related risk factors of diabetic foot.Methods A total of 134 diabetic patients were enrolled in the Department of Internal Medicine and Surgery of the Third Center Hospital of Baoding City, from January 2012 to July 2014.All patients were divided into two groups according to the diagnostic criteria of diabetic foot:diabetic mellitus (DM) group (n =63) and diabetic foot (DF) group (n =71).HbA1c, creatinine, uric acid, serum cystatin C, urine albumin and homocysteine were measured.The risk of diabetic foot was analyzed by Logistic regression.Results Serum homocysteine,cystatin C and HbA1c in DF group were higher than those in DM group,t value was 2.37,-4.00, and-2.96, respectively(all P ＜ O.05).Logistic regression analysis of multiple factors showed that homocysteine, serum cystatin C, HbA1c, smoking, body mass index were independent risk factors, the odd ratio(OR) was 1.095 (95％ CI: 1.031-1.162), 5.695 (95 ％ CI: 2.270-14.291), 1.807 (95 ％ CI: 1.285-2.541), 13.401 (95 ％ CI:4.297-41.792),1.246(95％CI:1.027-1.510),respectively (all P＜0.01).Conclusion Levels of cystain C and homocysteine are increased in patients with diabetic foot.Serum homocysteine, cystatin C, HbA1 c and smoking are independent risk factors for diabetic foot.
