CAJ | 학술논문

目的：探讨下呼吸道烟曲霉定植对重症哮喘患者气道黏蛋白MUC5 AC含量的影响。方法实验分为3组，分别观察3组患者的下呼吸道烟曲霉定植情况，ELISA法测定MUC5AC蛋白在下呼吸道痰液中的含量。结果在持续喘息的重症哮喘患者中真菌定植较非持续喘息的哮喘患者和健康人比例升高（P＜0．01），而MUC5 AC蛋白含量显著升高（ P＜0．01）。结论真菌定植是重症哮喘持续喘息的诱发因素之一，可以使重症哮喘患者气道分泌黏蛋白MUC5 AC蛋白的含量增加。
목적：탐토하호흡도연곡매정식대중증효천환자기도점단백MUC5 AC함량적영향。방법실험분위3조，분별관찰3조환자적하호흡도연곡매정식정황，ELISA법측정MUC5AC단백재하호흡도담액중적함량。결과재지속천식적중증효천환자중진균정식교비지속천식적효천환자화건강인비례승고（P＜0．01），이MUC5 AC단백함량현저승고（ P＜0．01）。결론진균정식시중증효천지속천식적유발인소지일，가이사중증효천환자기도분비점단백MUC5 AC단백적함량증가。
[ ABSTRACT] Objective To investigate the effect of Aspergillus colonization on the content of airway mucin MUC5AC in patients with severe asthma.Methods The experiment was divided into 3 groups,the colonization of Asper-gillus was observed respectively in lower respiratory tract in the three groups,and the content of MUC5AC protein in the sputum of the lower respiratory tract was detected by ELISA.Results In severe asthma patients with persistent wheez-ing,fungal colonization was higher than that of non persistent asthmatic patients and healthy individuals(P<0.01),and MUC5AC protein content was significantly higher(P<0.01).Conclusion Fungal colonization is one of the inducing factors of severe asthma,and fungal colonization can increase the content of MUC5AC protein in airway of patients with severe asthma.