CAJ | 학술논문

目的：探讨Ⅲ期非小细胞肺癌患者采用同步放化疗治疗的临床疗效。方法按照随机抛硬币法将74例Ⅲ期非小细胞肺癌患者分组为对照组（序贯放化疗）与观察组（同步放化疗），分别为37例。随访6～60个月，平均为（42．6±9．4）个月。统计2组患者临床疗效、生存时间及治疗期间所产生的不良反应。结果经治疗及随访发现，观察组临床治疗有效率为67．57％，明显高于对照组的48．65％（P＜0．05）；观察组平均生存时间为（19．9±4．1）个月，明显长于对照组（12．5±3．4）个月，P＜0．05。2组主要不良反应为消化道反应和骨髓抑制及放射性食管炎，但2组不良反应率比较，差异无统计学意义（ P＞0．05）。结论应用同步放化疗治疗Ⅲ期非小细胞肺癌疗效显著且安全。
목적：탐토Ⅲ기비소세포폐암환자채용동보방화료치료적림상료효。방법안조수궤포경폐법장74례Ⅲ기비소세포폐암환자분조위대조조（서관방화료）여관찰조（동보방화료），분별위37례。수방6～60개월，평균위（42．6±9．4）개월。통계2조환자림상료효、생존시간급치료기간소산생적불량반응。결과경치료급수방발현，관찰조림상치료유효솔위67．57％，명현고우대조조적48．65％（P＜0．05）；관찰조평균생존시간위（19．9±4．1）개월，명현장우대조조（12．5±3．4）개월，P＜0．05。2조주요불량반응위소화도반응화골수억제급방사성식관염，단2조불량반응솔비교，차이무통계학의의（ P＞0．05）。결론응용동보방화료치료Ⅲ기비소세포폐암료효현저차안전。
Objective To explore the clinical efficacy of chemoradiotherapy for stage Ⅲ non-small cell lung cancer. Methods According to the method of random flip a coin,74 cases of stageⅢnon-small cell lung cancer patients were divided into the control group ( sequential chemoradiotherapy) and the observation group ( chemoradiotherapy) ,37 cases in each.Follow up was 6 ~60 months,the average follow up was (42.6 ±9.4) months.Clinical curative effect,survival time and adverse reac-tions of the 2 groups of patients were recorded.Results After treatment and follow-up, effective rate in the observation group (67.57%) was significantly higher than of the control group(48.65%),P<0.05;the average survival time in the observation group was (19.9 ±4.1) months,which was significantly longer than that of the control group (12.5 ±3.4) months,P<0.05. The main adverse reactions were gastrointestinal reactions,bone marrow suppression and radiation esophagitis,but adverse reaction rates between the 2 groups had no significant difference,P>0.05.Conclusion Chemoradiotherapy for stage Ⅲ non-small cell lung cancer is effective and safe.