CAJ | 학술논문

目的：分析HIF-1α和c-MET受体与胃癌各临床病理特征及胃癌组织6r65的关系，为判断胃癌的预后及靶向治疗提供依据。方法采用免疫组织化学SP法，检测74例胃癌组织和74例癌旁胃组织（距癌灶2-5 cm）中HIF-1α、c-MET受体及CD34的表达。应用Kaplan-Meier法对患者进行生存分析。结果胃癌组织中HIF-1α及c-Met的表达水平显著高于癌旁组织（P＜0．05）；胃癌组织中HIF-1α表达与肿瘤分化程度、浸润深度、淋巴结转移、远处转移及分期有关（P＜0．05），而c-Met受体表达受肿瘤分化程度、浸润深度及分期的影响（P＜0．05）；胃癌组织中，HIF-1α与c-Met的表达呈显著相关性（γ＝0．365，P＜0．05）；HIF-1α及c-Met阳性表达的胃癌组织中MVD均显著高于阴性表达组（ P＜0．05）；生存分析显示，HIF-1α或c-Met阳性表达患者的生存时间显著短于阴性表达患者（P＜0．05）。结论 HIF-1α与c-Met表达共同参与了胃癌的发生、发展，可作为胃癌浸润和转移的重要判定指标。 HIF-1α可能通过上调c-Met的表达，诱导胃癌微环境中血管的生成而促进胃癌的转移。
목적：분석HIF-1α화c-MET수체여위암각림상병리특정급위암조직6r65적관계，위판단위암적예후급파향치료제공의거。방법채용면역조직화학SP법，검측74례위암조직화74례암방위조직（거암조2-5 cm）중HIF-1α、c-MET수체급CD34적표체。응용Kaplan-Meier법대환자진행생존분석。결과위암조직중HIF-1α급c-Met적표체수평현저고우암방조직（P＜0．05）；위암조직중HIF-1α표체여종류분화정도、침윤심도、림파결전이、원처전이급분기유관（P＜0．05），이c-Met수체표체수종류분화정도、침윤심도급분기적영향（P＜0．05）；위암조직중，HIF-1α여c-Met적표체정현저상관성（γ＝0．365，P＜0．05）；HIF-1α급c-Met양성표체적위암조직중MVD균현저고우음성표체조（ P＜0．05）；생존분석현시，HIF-1α혹c-Met양성표체환자적생존시간현저단우음성표체환자（P＜0．05）。결론 HIF-1α여c-Met표체공동삼여료위암적발생、발전，가작위위암침윤화전이적중요판정지표。 HIF-1α가능통과상조c-Met적표체，유도위암미배경중혈관적생성이촉진위암적전이。
Objective To study the expression of HIF-αand c-MET receptor and its correlation with clinicopathological features and angiogenesis of gastric carcinoma, And provide basis for the prognosis and targeted therapy in gastric carcinoma. Methods The expression of HIF-1αand c-MET receptor were detected by streptavidin perotridase in 74 cases of gastric carcino-ma and the paracarcinoma tissues.Patients were followed up after surgery,and Kaplan-Meier method was used for survival analy-sis.Results The expression of HIF-1αand c-MET in gastric carcinoma was significantly higher than the paired paracarcinoma (P<0.05).The expression of HIF-1αin gastric carcinoma was significantly associated with degrees of differentiation,the depth of invasion,lymph node metastasis,distant metastasis and stages,while the c-MET receptor was associated with degrees of differ-entiation,the depth of invasion and stages (P<0.05).The HIF-1αwas correlated with the c-MET receptor expression (γ=0.365,P<0.05) .MVD in gastric carcinoma tissues was significantly higher in the HIF-1αor c-MET receptor positive expression group than the negative group (P<0.05).The patients of high expression of HIF-1αor c-MET receptor lived shorter than low ex-pression group (P<0.05).Conclusion HIF-1αand c-MET receptor expression are correlated with development of gastric car-cinoma and can be candidates as important indicator of tumor invasion and metastasis.HIF-1αcan induce angiogenesis and pro-mote metastasis of gastric carcinoma through the upregulation of c-Met.