潍坊医学院学报
濰坊醫學院學報
유방의학원학보
Acta Academiae Medicinae Weifang
2015年
6期
439-441
,共3页
盖林林%管立学%李海波%褚锦锦
蓋林林%管立學%李海波%褚錦錦
개림림%관립학%리해파%저금금
T-SPOT.TB试验%肺结核%诊断
T-SPOT.TB試驗%肺結覈%診斷
T-SPOT.TB시험%폐결핵%진단
T-SPOT.TB assay%Pulmonary tuberculosis%Diagnosis
目的：探讨结核感染T细胞斑点试验（ T-SPOT．TB）在疑似肺结核患者中的应用价值。方法对98例疑似肺结核患者和53例健康对照组人群进行T-SPOT．TB检测，并与TB-Ab，ESR，CPR结果进行对比分析。结果①98例疑似肺结核病患者T-SPOT．TB阳性38例，阳性检出率为38．74％，其中31例临床最终确诊为肺结核，诊断敏感性为81．58％（31／38）；53例健康对照组人群T-SPOT．TB阳性3例，阳性检出率为5．60％，特异性为94．34％（50／53）。②98例疑似肺结核患者TB-Ab阳性21例，阳性率为21．43％，T-SPOT．TB阳性组和T-SPOT．TB阴性组患者TB-Ab阳性检出率分别为21．05％和21．67％，差异无统计学意义（ P＞0．05）；31例确诊的肺结核患者中TB-Ab阳性6例，诊断敏感性仅为19．35％，显著低于T-SPOT．TB诊断敏感性81．58％（χ2＝32．91，P＜0．01）。③T-SPOT．TB阳性和阴性组与ESR，CRP水平比较，差异均无统计学意义（P＞0．05）。结论 T-SPOT．TB试验是一种重要的肺结核病的辅助诊断技术，具有较高的敏感性和特异性，有助于结核病的快速诊断和治疗。
目的：探討結覈感染T細胞斑點試驗（ T-SPOT．TB）在疑似肺結覈患者中的應用價值。方法對98例疑似肺結覈患者和53例健康對照組人群進行T-SPOT．TB檢測，併與TB-Ab，ESR，CPR結果進行對比分析。結果①98例疑似肺結覈病患者T-SPOT．TB暘性38例，暘性檢齣率為38．74％，其中31例臨床最終確診為肺結覈，診斷敏感性為81．58％（31／38）；53例健康對照組人群T-SPOT．TB暘性3例，暘性檢齣率為5．60％，特異性為94．34％（50／53）。②98例疑似肺結覈患者TB-Ab暘性21例，暘性率為21．43％，T-SPOT．TB暘性組和T-SPOT．TB陰性組患者TB-Ab暘性檢齣率分彆為21．05％和21．67％，差異無統計學意義（ P＞0．05）；31例確診的肺結覈患者中TB-Ab暘性6例，診斷敏感性僅為19．35％，顯著低于T-SPOT．TB診斷敏感性81．58％（χ2＝32．91，P＜0．01）。③T-SPOT．TB暘性和陰性組與ESR，CRP水平比較，差異均無統計學意義（P＞0．05）。結論 T-SPOT．TB試驗是一種重要的肺結覈病的輔助診斷技術，具有較高的敏感性和特異性，有助于結覈病的快速診斷和治療。
목적：탐토결핵감염T세포반점시험（ T-SPOT．TB）재의사폐결핵환자중적응용개치。방법대98례의사폐결핵환자화53례건강대조조인군진행T-SPOT．TB검측，병여TB-Ab，ESR，CPR결과진행대비분석。결과①98례의사폐결핵병환자T-SPOT．TB양성38례，양성검출솔위38．74％，기중31례림상최종학진위폐결핵，진단민감성위81．58％（31／38）；53례건강대조조인군T-SPOT．TB양성3례，양성검출솔위5．60％，특이성위94．34％（50／53）。②98례의사폐결핵환자TB-Ab양성21례，양성솔위21．43％，T-SPOT．TB양성조화T-SPOT．TB음성조환자TB-Ab양성검출솔분별위21．05％화21．67％，차이무통계학의의（ P＞0．05）；31례학진적폐결핵환자중TB-Ab양성6례，진단민감성부위19．35％，현저저우T-SPOT．TB진단민감성81．58％（χ2＝32．91，P＜0．01）。③T-SPOT．TB양성화음성조여ESR，CRP수평비교，차이균무통계학의의（P＞0．05）。결론 T-SPOT．TB시험시일충중요적폐결핵병적보조진단기술，구유교고적민감성화특이성，유조우결핵병적쾌속진단화치료。
[ ABSTRACT] Objective To investigate the usefulness of the T-cell enzyme-linked immunospot assay ( T-SPOT.TB) for diagnosis of pulmonary tuberculosis in suspected patients.Methods Ninety-eight patients with suspected pulmonary tuberculosis(patient group) and fifty-three healthy subjects(controls) were enrolled.The T-SPOT.TB test, TB-Ab,ESR and CRP were performed for all subjects.Results ①Thirty-eight cases were T-SPOT.TB-positive in sus-pected pulmonary tuberculosis group,the positive rate was 38.74%(38/98) ,of which 31 cases were finally diagnosed as pulmonary tuberculosis,the diagnostic sensitivity was 81.58%(31/38).Three cases were T-SPOT.TB-positive in health-y controls,the positive rate was 5.60%(3/53),the specificity of T-SPOT.TB test was 94.34%(50/53).②Twenty-one cases were TB-Ab-positive in suspected pulmonary tuberculosis group,the positive rate was 21.43%(21/98),and TB-Ab-positive rates were 21.05% and 21.67% in the T-SPOT.TB -positive and T-SPOT,respectively.In TB -negative groups,there was no significant differences(P>0.05).Six cases were TB-Ab-positive in 31 patients diagnosed as pul-monary tuberculosis,the diagnostic sensitivity was only 19.35%(6/31),it is significantly lower than that of T-SPOT.T test(81.58%)(χ2 =32.91,P<0.01).③There were no significant differences between the levels of ESR and CRP in the T-SPOT.TB positive and negative patient group(P>0.05).Conclusion T-SPOT.TB test is an important supple-mentary method for diagnosis of pulmonary tuberculosis,with higher sensitivity and stronger specificity.It would be help-ful for the rapid diagnosis and treatment for tuberculosis.
