实用癌症杂志
實用癌癥雜誌
실용암증잡지
The Practical Journal of Cancer
2015年
12期
1800-1802,1811
,共4页
鼻咽癌%肌成束蛋白%E-选择素%相关性
鼻嚥癌%肌成束蛋白%E-選擇素%相關性
비인암%기성속단백%E-선택소%상관성
Nasopharyngeal carcinoma%Muscle bundle protein(Fascin-1)%E-selectin%Correlation
目的：探讨鼻咽癌患者血清肌成束蛋白（ Fascin-1）、E-选择素（ E-selectin）水平与其临床病理因素的相关性。方法收集鼻咽癌患者共90例，资料分析过程中因数据遗失剔除4例，最后完成86例；同期选择体检健康者50例为对照组；应用酶联免疫吸附（Elisa）法检测两组血清Fascin-1和E-selectin水平。结果与对照组比较，鼻咽癌组患者血清Fascin-1和E-selectin水平均显著增高（P＜0．01）。血清Fascin-1和E-selectin的表达水平与鼻咽癌患者的年龄、性别、大小、病理分型无显著相关性（P＞0．05），而与TNM分期、淋巴结转移呈显著性相关（P＜0．01）。随访3年，20例死亡，66例存活。死亡者入院时血清Fascin-1和E-selectin水平均明显高于存活者入院时，比较差异有统计学意义（ P＜0．01）。结论鼻咽癌患者血清Fascin-1和E-selectin的表达水平明显增高，与鼻咽癌的恶性程度密切相关，有望成为评价临床治疗鼻咽癌患者预后的重要标志物。
目的：探討鼻嚥癌患者血清肌成束蛋白（ Fascin-1）、E-選擇素（ E-selectin）水平與其臨床病理因素的相關性。方法收集鼻嚥癌患者共90例，資料分析過程中因數據遺失剔除4例，最後完成86例；同期選擇體檢健康者50例為對照組；應用酶聯免疫吸附（Elisa）法檢測兩組血清Fascin-1和E-selectin水平。結果與對照組比較，鼻嚥癌組患者血清Fascin-1和E-selectin水平均顯著增高（P＜0．01）。血清Fascin-1和E-selectin的錶達水平與鼻嚥癌患者的年齡、性彆、大小、病理分型無顯著相關性（P＞0．05），而與TNM分期、淋巴結轉移呈顯著性相關（P＜0．01）。隨訪3年，20例死亡，66例存活。死亡者入院時血清Fascin-1和E-selectin水平均明顯高于存活者入院時，比較差異有統計學意義（ P＜0．01）。結論鼻嚥癌患者血清Fascin-1和E-selectin的錶達水平明顯增高，與鼻嚥癌的噁性程度密切相關，有望成為評價臨床治療鼻嚥癌患者預後的重要標誌物。
목적：탐토비인암환자혈청기성속단백（ Fascin-1）、E-선택소（ E-selectin）수평여기림상병리인소적상관성。방법수집비인암환자공90례，자료분석과정중인수거유실척제4례，최후완성86례；동기선택체검건강자50례위대조조；응용매련면역흡부（Elisa）법검측량조혈청Fascin-1화E-selectin수평。결과여대조조비교，비인암조환자혈청Fascin-1화E-selectin수평균현저증고（P＜0．01）。혈청Fascin-1화E-selectin적표체수평여비인암환자적년령、성별、대소、병리분형무현저상관성（P＞0．05），이여TNM분기、림파결전이정현저성상관（P＜0．01）。수방3년，20례사망，66례존활。사망자입원시혈청Fascin-1화E-selectin수평균명현고우존활자입원시，비교차이유통계학의의（ P＜0．01）。결론비인암환자혈청Fascin-1화E-selectin적표체수평명현증고，여비인암적악성정도밀절상관，유망성위평개림상치료비인암환자예후적중요표지물。
Objective To investigate serum level of serum muscle bundle protein(Fascin-1) and E-selectin in patients with nasopharyngeal carcinoma and its correlation with clinicopathological parameters.Methods 90 patients with nasopharyngeal carcinoma were selected with 4 cases weeded out by data missing and 86 cases completed.50 healthy cases was the control group. Serum Fascin-1 and E-selectin were detected by Elisa method in both groups.Results Compared with the control group,serum levels of Fascin-1 and E-selectin of nasopharyngeal carcinoma group increased obviously (P<0.01).Serum level of Fascin-1 and E-selectin had no significant correlation with age,gender,size,and pathological type(P>0.05),but were significantly correlated with TNM stage and lymph node metastasis (P<0.01).After 3-year follow up,20 cases were dead and 66 survived.Serum level of Fascin-1 and E-selectin on admission in the death cases were remarkably higher than those survived,there had statistical signif-icance(P<0.01).Conclusion Serum level of Fascin-1 and E-selectin of nasopharyngeal carcinoma increased obviously and are closely related with malignancy grade,and it could be important prognostic marker of evaluating prognosis.
