CAJ | 학술논문

目的：探讨癌胚抗原（CEA）、糖类抗原125（CA125）、细胞角蛋白19片段21-1（CYFRA21-1）、神经元特异性烯醇化酶（NSE）以及鳞状上皮细胞癌相关抗原（SCC）5种肿瘤标志物联合检测在肺癌诊断中的价值。方法随机选择肺癌患者102例、肺良性疾病65例以及同期体检健康者80例作为研究对象。所有研究对象均于空腹抽取5 ml外周静脉血，检测CEA、CA125、CYFRA21-1、NSE和SCC浓度。结果肺癌组患者CEA、CA125、CYFRA21-1、NSE及SCC检测阳性率均显著高于肺良性疾病患者、健康组（P＜0．05）；5种肿瘤标志物联合检测诊断肺癌的敏感度（91．18％）显著高于CEA、CA125、CYFRA21-1、NSE及SCC单项检测敏感度（42．20％、42．16％、50．00％、36．27％、20．59％）（P＜0．05）。结论CEA、CA125、CYFRA21-1、NSE及SCC在肺癌的临床诊断与分型中均具有一定价值，5项肿瘤标志物的联合检测可以显著提高其敏感性。
목적：탐토암배항원（CEA）、당류항원125（CA125）、세포각단백19편단21-1（CYFRA21-1）、신경원특이성희순화매（NSE）이급린상상피세포암상관항원（SCC）5충종류표지물연합검측재폐암진단중적개치。방법수궤선택폐암환자102례、폐량성질병65례이급동기체검건강자80례작위연구대상。소유연구대상균우공복추취5 ml외주정맥혈，검측CEA、CA125、CYFRA21-1、NSE화SCC농도。결과폐암조환자CEA、CA125、CYFRA21-1、NSE급SCC검측양성솔균현저고우폐량성질병환자、건강조（P＜0．05）；5충종류표지물연합검측진단폐암적민감도（91．18％）현저고우CEA、CA125、CYFRA21-1、NSE급SCC단항검측민감도（42．20％、42．16％、50．00％、36．27％、20．59％）（P＜0．05）。결론CEA、CA125、CYFRA21-1、NSE급SCC재폐암적림상진단여분형중균구유일정개치，5항종류표지물적연합검측가이현저제고기민감성。
Objective To study the value of serum carcinoembryonic antigen ( CEA ) , carbohydrate antigen 125 (CA125),cytokeratin 19 fragments (CYFRA21-1),neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) in the diagnosis of lung cancer.Methods 102 cases of lung cancer patients,65 cases of lung benign diseases and 80 cases of healthy patients were randomly selected.5ml peripheral venous blood was extracted from every research object and the SCC,NSE, CA125,CYFRA21-1 and CEA were detected.Results The positive rates of SCC,NSE,CA125,CYFRA21-1 and CEA of patients in lung cancer group were significantly higher than those in other 2 groups(P<0.05).The sensitivity of 5 tumor markers com-bined detection in the diagnosis of lung cancer (91.18%) was significantly higher than each one of CEA,CA125,CYFRA21-1, NSE and SCC(40.20%,42.16%,50.00%,36.27%,20.59%)(P<0.05).Conclusion CEA,CA125,CYFRA21-1,NSE and SCC have certain value in the clinical diagnosis and classification of lung cancer,and the combined detection of the 5 tumor mark-ers can significantly increase the sensitivity.