CAJ | 학술논문

目的：通过分析肿瘤凋亡抑制基因（COX-2）及抑癌基因（PTEN）在胃癌中的表达，探讨其与胃癌淋巴结转移的关系。方法用免疫组化S-P法分别检测淋巴结转移组与非淋巴结转移组胃癌组织PTEN与COX-2表达情况。结果淋巴结转移组及非淋巴结转移标本中COX-2的表达阳性率分别为82．6％，35．7％，两组比较差异有统计学意义（P＜0．05）；淋巴结转移组及非淋巴结转移标本中PTEN的表达阳性率分别为38．5％，85．7％，两组比较差异有统计学意义（P＜0．05）。结论 COX-2与PTEN可能存在相互作用，共同参与了胃癌淋巴结的转移。
목적：통과분석종류조망억제기인（COX-2）급억암기인（PTEN）재위암중적표체，탐토기여위암림파결전이적관계。방법용면역조화S-P법분별검측림파결전이조여비림파결전이조위암조직PTEN여COX-2표체정황。결과림파결전이조급비림파결전이표본중COX-2적표체양성솔분별위82．6％，35．7％，량조비교차이유통계학의의（P＜0．05）；림파결전이조급비림파결전이표본중PTEN적표체양성솔분별위38．5％，85．7％，량조비교차이유통계학의의（P＜0．05）。결론 COX-2여PTEN가능존재상호작용，공동삼여료위암림파결적전이。
[ ABSTRACT] Objective To investigate the expression of tumor apoptosis inhibiting genegene( COX-2) and tumor suppressor gene ( PTEN) in gastric cancer and to explore its relationship with lymph node metastasis.Methods The expressions of COX-2 and PTEN were detected by immunohistochemical S-P method in the lymph node metastasis group and non lymph node metastasis group.Results The posi-tive expression rate of COX-2 in lymph node metastasis group was 82.6%,and in non lymph node metastasis group,the rate was 35.7%,and the difference between the two groups was statistically significant(P<0.05);the positive expression rate of PTEN in lymph node metastasis group was 38.5%,and in non lymph node metastasis group it was 85.7%,there was significant difference between the two groups(P<0. 05).Conclusion There may be some interaction between COX-2 and PTEN and they may be involved together in the metastasis of gastric cancer.