中国肝脏病杂志（电子版）
中國肝髒病雜誌（電子版）
중국간장병잡지（전자판）
Chinese Journal of Liver Diseases (Electronic Version)
2015年
3期
109-111
,共3页
肿瘤标志物%乙型肝炎%HBsAg阳性%诊断价值
腫瘤標誌物%乙型肝炎%HBsAg暘性%診斷價值
종류표지물%을형간염%HBsAg양성%진단개치
Tumor markers%HBsAg positive hepatitis B liver cancer%Diagnostic value
目的：探讨血清十项肿瘤标志物联合检测对乙型肝炎HBsAg阳性肝癌的诊断价值。方法统计分析2011年5月至2014年1月本院收治的292例HBsAg阳性肝癌患者的血清标本资料。结果肝癌组和非肝癌组患者的血清GP73和其余9种肿瘤标志物均有相关性（非肝癌组的9种肿瘤标志物的P =0.000，肝癌组SF、CEA、CA125、CA15-3、ALP的P =0.000；AFP的P =0.007，CA19-9的P =0.047；GGT的P =0.002，LAP的P =0.028）；肝癌组患者的AFP、GGT、LAP相关系数均明显比非肝癌组小；肝癌组患者的GP73、AFP、LAP水平均明显比乙型肝炎肝硬化组、慢性乙型肝炎组、对照组高（P =0.000）；GP73的ROC曲线下面积为0.792，比CA19-9、CA15-3、CA125、CEA、GGT、LAP、SF大（与CA19-9相比P =0.002外，其余P =0.000）；PRE的AUC均明显比其他单项指标高（P =0.000）。结论血清十项肿瘤标志物联合检测对乙型肝炎HBsAg阳性肝癌具有较高的诊断价值。
目的：探討血清十項腫瘤標誌物聯閤檢測對乙型肝炎HBsAg暘性肝癌的診斷價值。方法統計分析2011年5月至2014年1月本院收治的292例HBsAg暘性肝癌患者的血清標本資料。結果肝癌組和非肝癌組患者的血清GP73和其餘9種腫瘤標誌物均有相關性（非肝癌組的9種腫瘤標誌物的P =0.000，肝癌組SF、CEA、CA125、CA15-3、ALP的P =0.000；AFP的P =0.007，CA19-9的P =0.047；GGT的P =0.002，LAP的P =0.028）；肝癌組患者的AFP、GGT、LAP相關繫數均明顯比非肝癌組小；肝癌組患者的GP73、AFP、LAP水平均明顯比乙型肝炎肝硬化組、慢性乙型肝炎組、對照組高（P =0.000）；GP73的ROC麯線下麵積為0.792，比CA19-9、CA15-3、CA125、CEA、GGT、LAP、SF大（與CA19-9相比P =0.002外，其餘P =0.000）；PRE的AUC均明顯比其他單項指標高（P =0.000）。結論血清十項腫瘤標誌物聯閤檢測對乙型肝炎HBsAg暘性肝癌具有較高的診斷價值。
목적：탐토혈청십항종류표지물연합검측대을형간염HBsAg양성간암적진단개치。방법통계분석2011년5월지2014년1월본원수치적292례HBsAg양성간암환자적혈청표본자료。결과간암조화비간암조환자적혈청GP73화기여9충종류표지물균유상관성（비간암조적9충종류표지물적P =0.000，간암조SF、CEA、CA125、CA15-3、ALP적P =0.000；AFP적P =0.007，CA19-9적P =0.047；GGT적P =0.002，LAP적P =0.028）；간암조환자적AFP、GGT、LAP상관계수균명현비비간암조소；간암조환자적GP73、AFP、LAP수평균명현비을형간염간경화조、만성을형간염조、대조조고（P =0.000）；GP73적ROC곡선하면적위0.792，비CA19-9、CA15-3、CA125、CEA、GGT、LAP、SF대（여CA19-9상비P =0.002외，기여P =0.000）；PRE적AUC균명현비기타단항지표고（P =0.000）。결론혈청십항종류표지물연합검측대을형간염HBsAg양성간암구유교고적진단개치。
Objective To investigate the diagnostic value of combined detection of ten serum tumor markers on HBsAg positive patients with liver cancer. Methods The serum specimen data of 292 HBsAg positive patients with liver cancer (2011.05~2014.01) in our hospital were analyzed. Results The serum GP73 and other 9 kinds of tumor markers of the patients were correlated between liver cancer group and no liver cancer group (the P value of no liver cancer group was 0.000, the P values of liver cancer group in SF, CEA, CA125, CA15-3, and ALP were 0.000, and in AFP, CA19-9, GGT, and LAP were 0.007, 0.047, 0.002, 0.028, respectively);the correlation coefficient of AFP, GGT, LAP of patients in liver cancer group were significantly smaller than the non-liver cancer group. The level of GP73, AFP, LAP of liver cancer patients were significantly higher than hepatitis B cirrhosis group, chronic hepatitis B group and control group (P = 0.000); ROC area under the curve (AUC) of GP73 (0.792) was bigger than CA19-9, CA15-3, CA125, CEA, GGT, LAP and SF. AUC of PRE were obviously higher than other single indexes (P = 0.000). Conclusions The combined detection of ten serum tumor markers on HBsAg positive for hepatitis B liver cancer has high diagnostic value.
