中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
11期
1213-1217
,共5页
卒中%尿酸%颈动脉疾病
卒中%尿痠%頸動脈疾病
졸중%뇨산%경동맥질병
Stroke%Uric acid%Carotid artery diseases
目的 探讨老年缺血性脑卒中患者颈动脉硬化及颅内动脉狭窄与血清尿酸水平的关系. 方法 选取186例老年缺血性脑卒中患者进行颈动脉超声及经颅多普勒检查,分别判断颈动脉内中膜厚度(IMT)及颅内动脉狭窄情况.根据颈动脉IMT分为内膜正常组、内膜增厚组、斑块组及狭窄组;根据颅内动脉狭窄分为狭窄组和无狭窄组.检测患者血清尿酸(UA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的浓度,采用Logistic回归分析颈动脉硬化、颅内动脉狭窄的相关因素. 结果 斑块组及狭窄组高血压者比例、冠心病者比例、TC水平较内膜正常组及内膜增厚组高,差异有统计学意义(均P＜0.05);随着IMT增加,血尿酸水平依次增加(F=11.386,P=0.000);多分类Logistic回归分析显示,血尿酸水平高是颈动脉硬化的独立危险因素(OR=3.486,P=0.013).186例缺血性脑卒中患者中43例(23.1％)发生颅内动脉狭窄,狭窄组血尿酸水平较无狭窄组明显增高[(517.6±63.2) μmol/L比(401.3±55.4)μmol/L,t=9.372,P=0.013];二分类Logistic回归分析显示,血尿酸水平高是颅内动脉狭窄的独立危险因素(OR=1.914,P=0.022). 结论 老年缺血性脑卒中患者颈动脉硬化程度及颅内动脉狭窄与高尿酸血症有密切的关系,提示血尿酸水平可反映颈动脉硬化程度.
目的 探討老年缺血性腦卒中患者頸動脈硬化及顱內動脈狹窄與血清尿痠水平的關繫. 方法 選取186例老年缺血性腦卒中患者進行頸動脈超聲及經顱多普勒檢查,分彆判斷頸動脈內中膜厚度(IMT)及顱內動脈狹窄情況.根據頸動脈IMT分為內膜正常組、內膜增厚組、斑塊組及狹窄組;根據顱內動脈狹窄分為狹窄組和無狹窄組.檢測患者血清尿痠(UA)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)的濃度,採用Logistic迴歸分析頸動脈硬化、顱內動脈狹窄的相關因素. 結果 斑塊組及狹窄組高血壓者比例、冠心病者比例、TC水平較內膜正常組及內膜增厚組高,差異有統計學意義(均P＜0.05);隨著IMT增加,血尿痠水平依次增加(F=11.386,P=0.000);多分類Logistic迴歸分析顯示,血尿痠水平高是頸動脈硬化的獨立危險因素(OR=3.486,P=0.013).186例缺血性腦卒中患者中43例(23.1％)髮生顱內動脈狹窄,狹窄組血尿痠水平較無狹窄組明顯增高[(517.6±63.2) μmol/L比(401.3±55.4)μmol/L,t=9.372,P=0.013];二分類Logistic迴歸分析顯示,血尿痠水平高是顱內動脈狹窄的獨立危險因素(OR=1.914,P=0.022). 結論 老年缺血性腦卒中患者頸動脈硬化程度及顱內動脈狹窄與高尿痠血癥有密切的關繫,提示血尿痠水平可反映頸動脈硬化程度.
목적 탐토노년결혈성뇌졸중환자경동맥경화급로내동맥협착여혈청뇨산수평적관계. 방법 선취186례노년결혈성뇌졸중환자진행경동맥초성급경로다보륵검사,분별판단경동맥내중막후도(IMT)급로내동맥협착정황.근거경동맥IMT분위내막정상조、내막증후조、반괴조급협착조;근거로내동맥협착분위협착조화무협착조.검측환자혈청뇨산(UA)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)적농도,채용Logistic회귀분석경동맥경화、로내동맥협착적상관인소. 결과 반괴조급협착조고혈압자비례、관심병자비례、TC수평교내막정상조급내막증후조고,차이유통계학의의(균P＜0.05);수착IMT증가,혈뇨산수평의차증가(F=11.386,P=0.000);다분류Logistic회귀분석현시,혈뇨산수평고시경동맥경화적독립위험인소(OR=3.486,P=0.013).186례결혈성뇌졸중환자중43례(23.1％)발생로내동맥협착,협착조혈뇨산수평교무협착조명현증고[(517.6±63.2) μmol/L비(401.3±55.4)μmol/L,t=9.372,P=0.013];이분류Logistic회귀분석현시,혈뇨산수평고시로내동맥협착적독립위험인소(OR=1.914,P=0.022). 결론 노년결혈성뇌졸중환자경동맥경화정도급로내동맥협착여고뇨산혈증유밀절적관계,제시혈뇨산수평가반영경동맥경화정도.
Objective To investigate the relationship of serum uric acid level with carotid atherosclerosis and intracranial stenosis in patients with cerebral ischemic stroke.Methods 186 patients checked by Color Doppler Flow Imaging (CDFI) and Transcranial Doppler (TCD) were enrolled.According to the degree of carotid intima-media thickness (IMT), patients were divided into normal group, and intima thicken group, the plaque shaping group and the vascular stenosis group.According to the degree of intracranial stenosis, patients were divided into stenosis group and nonstenosis group.The serum levels of uric acid (UA), triglycerides (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected.The relative factors for carotid atherosclerosis and intracranial stenosis were analyzed by multiple logistic regression analysis.Results Compared with normal group and intima thicken group, the percentage of patients with hypertension, coronary heart disease and serum TC level were increased in plaque shaping group and vascular stenosis group (P＜0.05 for all).With the increase of carotid IMT, serum UA level was also gradually increased (F=11.386, P =0.000).Logistic regression analysis showed that serum UA level was the independent risk factor for carotid atherosclerosis (OR=3.486, P=0.013).Among 186 patients, 43 cases (23.1％) had intracranial vascular stenosis.The UA level was higher in stenosis group than in non stenosis group (t=9.372, P=0.013).Logistic regression analysis showed that serum UA level were the independent risk factors for intracranial arterial stenosis (OR =1.914, P=0.022).Conclusions The occurrence of carotid atherosclerosis and intracranial stenosis are closely related with hyperuricemia in patients with cerebral ischemic stroke, which indicates serum uric acid level may reflect the degree of carotid artery atherosclerosis.
