CAJ | 학술논문

MicroRNA 作为非编码小 RNA 分子在转录和后转录水平调控基因表达过程中扮演重要角色,已成为当前分子生物学的研究热点之一。近期已有研究证实,一些在肌肉细胞中特异表达microRNA包括miR-1、miR-206和 miR-133可能对肌肉生长和发育很关键。众所周知,肌肉不仅是机体重要结构组织和运动器官,而且还是水产畜牧产品的重要蛋白源。聚焦这些肌肉特异myomiRs在肌肉生长和发育中的功能机理研究,不仅有助于揭示某些疾病的分子机制和解决医学上基因治疗难题；同时也为畜牧水产养殖提供科学应用理论依据。综述我们概括了miR-1, miR-206和miR-133最新研究进展,这将有助于深入了解其作用于肌肉生长和发育的功能和分子机制。
MicroRNA 작위비편마소 RNA 분자재전록화후전록수평조공기인표체과정중분연중요각색,이성위당전분자생물학적연구열점지일。근기이유연구증실,일사재기육세포중특이표체microRNA포괄miR-1、miR-206화 miR-133가능대기육생장화발육흔관건。음소주지,기육불부시궤체중요결구조직화운동기관,이차환시수산축목산품적중요단백원。취초저사기육특이myomiRs재기육생장화발육중적공능궤리연구,불부유조우게시모사질병적분자궤제화해결의학상기인치료난제；동시야위축목수산양식제공과학응용이론의거。종술아문개괄료miR-1, miR-206화miR-133최신연구진전,저장유조우심입료해기작용우기육생장화발육적공능화분자궤제。
MicroRNAs are small non-coding RNA molecules that play important roles in the transcriptional and post-transcriptional regulation of gene expression. MicroRNAs have become one of the hotspot issues in molecular bi-ology. Recently several microRNAs have been identified including miR-1, miR-206 and miR-133 that are specifically expressed in muscle cells and may be crucially involved in the development and growth of muscles. Muscles are an important part of body structure as well as a locomotive organ, and they are also the main protein source in aquaculture and animal husbandry. Therefore, functional studies of the roles of muscle-specific microRNAs will help uncover the mechanisms of certain diseases, facilitate medical gene therapy, and provide guidance for the animal husbandry and fishery. In this review we summarized the latest research on miR-1, miR-206 and miR-133 that shed lights on better understanding of their functions in muscle development and growth.