实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2015年
10期
11-14
,共4页
2 型糖尿病%高尿酸血症%超敏 C 反应蛋白%尿微量白蛋白%血液流变学
2 型糖尿病%高尿痠血癥%超敏 C 反應蛋白%尿微量白蛋白%血液流變學
2 형당뇨병%고뇨산혈증%초민 C 반응단백%뇨미량백단백%혈액류변학
type 2 diabetes%hyperuricemia%hypersensitive C-reactive protein%urinary microalbumin%hemorheology
目的：检测2型糖尿病合并高尿酸血症患者尿微量白蛋白（MAU）、血超敏 C 反应蛋白（hs-CRP）和血液流变学指标，探讨其临床意义。方法对2型糖尿病合并高尿酸血症患者（HUA 组）、2型糖尿病尿酸正常患者（NUA 组）及健康体检者（对照组）各120例进行 MAU、hs-CRP 和血液流变学指标（全血黏度低切、全血黏度中切、全血黏度高切、血浆黏度、红细胞比积、纤维蛋白原、血沉、红细胞变形指数、红细胞聚集指数、红细胞刚性指数）检测。结果HUA 组与 NUA 组的代谢综合征（MS）患病率分别为30．0％（36／120）与15．0％（18／120），2组比较差异有统计学意义（χ2＝4．69，P ＜0．05）。根据 MS 诊断标准，HUA 组合并1、2种代谢异常率低于 NUA 组，合并3、4种代谢异常率高于 NUA 组（P ＜0．05）。HUA 组及 NUA 组的 MAU、hs-CRP 水平均显著高于对照组，HUA 组高于 NUA 组（P ＜0．01或 P ＜0．05）。HUA 组、NUA 组血液流变学各项指标均高于对照组（均 P ＜0．01）；HUA组的全血黏度（低切、中切、高切）、血浆黏度、红细胞变形指数、红细胞聚集指数及红细胞刚性指数均高于 NUA 组（P ＜0．05），2组血沉、红细胞压积和纤维蛋白原比较差异无统计学意义（P ＞0．05）。结论MAU、hs-CRP 和血液流变学指标检测对2型糖尿病合并高尿酸血症患者有一定的临床意义。
目的：檢測2型糖尿病閤併高尿痠血癥患者尿微量白蛋白（MAU）、血超敏 C 反應蛋白（hs-CRP）和血液流變學指標，探討其臨床意義。方法對2型糖尿病閤併高尿痠血癥患者（HUA 組）、2型糖尿病尿痠正常患者（NUA 組）及健康體檢者（對照組）各120例進行 MAU、hs-CRP 和血液流變學指標（全血黏度低切、全血黏度中切、全血黏度高切、血漿黏度、紅細胞比積、纖維蛋白原、血沉、紅細胞變形指數、紅細胞聚集指數、紅細胞剛性指數）檢測。結果HUA 組與 NUA 組的代謝綜閤徵（MS）患病率分彆為30．0％（36／120）與15．0％（18／120），2組比較差異有統計學意義（χ2＝4．69，P ＜0．05）。根據 MS 診斷標準，HUA 組閤併1、2種代謝異常率低于 NUA 組，閤併3、4種代謝異常率高于 NUA 組（P ＜0．05）。HUA 組及 NUA 組的 MAU、hs-CRP 水平均顯著高于對照組，HUA 組高于 NUA 組（P ＜0．01或 P ＜0．05）。HUA 組、NUA 組血液流變學各項指標均高于對照組（均 P ＜0．01）；HUA組的全血黏度（低切、中切、高切）、血漿黏度、紅細胞變形指數、紅細胞聚集指數及紅細胞剛性指數均高于 NUA 組（P ＜0．05），2組血沉、紅細胞壓積和纖維蛋白原比較差異無統計學意義（P ＞0．05）。結論MAU、hs-CRP 和血液流變學指標檢測對2型糖尿病閤併高尿痠血癥患者有一定的臨床意義。
목적：검측2형당뇨병합병고뇨산혈증환자뇨미량백단백（MAU）、혈초민 C 반응단백（hs-CRP）화혈액류변학지표，탐토기림상의의。방법대2형당뇨병합병고뇨산혈증환자（HUA 조）、2형당뇨병뇨산정상환자（NUA 조）급건강체검자（대조조）각120례진행 MAU、hs-CRP 화혈액류변학지표（전혈점도저절、전혈점도중절、전혈점도고절、혈장점도、홍세포비적、섬유단백원、혈침、홍세포변형지수、홍세포취집지수、홍세포강성지수）검측。결과HUA 조여 NUA 조적대사종합정（MS）환병솔분별위30．0％（36／120）여15．0％（18／120），2조비교차이유통계학의의（χ2＝4．69，P ＜0．05）。근거 MS 진단표준，HUA 조합병1、2충대사이상솔저우 NUA 조，합병3、4충대사이상솔고우 NUA 조（P ＜0．05）。HUA 조급 NUA 조적 MAU、hs-CRP 수평균현저고우대조조，HUA 조고우 NUA 조（P ＜0．01혹 P ＜0．05）。HUA 조、NUA 조혈액류변학각항지표균고우대조조（균 P ＜0．01）；HUA조적전혈점도（저절、중절、고절）、혈장점도、홍세포변형지수、홍세포취집지수급홍세포강성지수균고우 NUA 조（P ＜0．05），2조혈침、홍세포압적화섬유단백원비교차이무통계학의의（P ＞0．05）。결론MAU、hs-CRP 화혈액류변학지표검측대2형당뇨병합병고뇨산혈증환자유일정적림상의의。
ABSTRACT:Objective To detect urinary microalbumin (MAU)levels,blood hypersensitive C-reactive protein (hs-CRP)levels and hemodynamic indexes in type 2 diabetic patients with hype-ruricemia,and to explore their clinical significances.Methods The urinary MAU levels,blood hs-CRP levels and hemodynamic indexes (whole blood viscosity at low,medium and high shear rates,plasma viscosity,hematocrit,fibrinogen,erythrocyte sedimentation rate,erythrocyte de-formation index,erythrocyte aggregation index,erythrocyte rigidity index,etc.)were measured in 120 type 2 diabetic patients with hyperuricemia (HUA group),120 type 2 diabetic patients with normal uric acid levels (NUA group ) and 120 healthy subjects (control group ).Results The incidence of metabolic syndrome (MS)in HUA group (30.0%,36/120)was significantly higher than that in NUA group (15.0%,18/120)(χ2 =4.69,P <0.05).According to the criteria for the diagnosis of MS,the proportion of patients with 1 or 2 types of metabolic abnormalities in HUA was lower than that in NUA group,but the proportion of patients with 3 or 4 types of met-abolic abnormalities in HUA was higher than that in NUA group (P <0.05).The levels of urina-ry MAU and blood hs-CRP in NUA group were higher than those in control group,but were low-er than those in HUA group (P <0.01 or P <0.05).All hemodynamic indexes in control group were lower than those in HUA group or NUA group (P <0.01).Whole blood viscosity at low, medium and high shear rates,plasma viscosity,erythrocyte deformation index,erythrocyte aggre-gation index,and erythrocyte rigidity index in HUA group were higher than those in NUA group (P <0.05).However,no significant differences in erythrocyte sedimentation rate,fibrinogen and hematocrit were found between the two groups (P >0.05).Conclusion The detection of urinary MAU levels,blood hs-CRP levels and hemodynamic indexes is of great significance in type 2 dia-betic patients with hyperuricemia.
