CAJ | 학술논문

非酒精性脂肪性肝病（NAFLD）是与遗传易感性和胰岛素抵抗（IR）密切相关的代谢应激性肝病，目前亦认为是代谢综合征（MS）的肝脏表现，常常与肥胖、2型糖尿病、高血压病、高脂血症以及MS 等合并存在。近年来，NAFLD 的患病率逐年增高，并且在2型糖尿病、肥胖患者中其患病率更高。动脉粥样硬化（AS）是心血管疾病（CVD）的基础，而目前研究发现 NAFLD 与 CVD 关系密切， NAFLD 患者主要死亡原因是 CVD 和恶性肿瘤，NAFLD 与 AS 关系亦密切，其机制目前仍不明确，可能涉及到胰岛素抵抗、血脂代谢紊乱、氧化应激、炎症反应、脂肪激素水平变化和肝功能等方面。本文就 NAFLD 和 AS 间的相关性及可能机制进行综述。
비주정성지방성간병（NAFLD）시여유전역감성화이도소저항（IR）밀절상관적대사응격성간병，목전역인위시대사종합정（MS）적간장표현，상상여비반、2형당뇨병、고혈압병、고지혈증이급MS 등합병존재。근년래，NAFLD 적환병솔축년증고，병차재2형당뇨병、비반환자중기환병솔경고。동맥죽양경화（AS）시심혈관질병（CVD）적기출，이목전연구발현 NAFLD 여 CVD 관계밀절， NAFLD 환자주요사망원인시 CVD 화악성종류，NAFLD 여 AS 관계역밀절，기궤제목전잉불명학，가능섭급도이도소저항、혈지대사문란、양화응격、염증반응、지방격소수평변화화간공능등방면。본문취 NAFLD 화 AS 간적상관성급가능궤제진행종술。
Nonalcoholic fatty liver disease (NAFLD), a metabolic stress-induced liver disease, is closely related to genetic susceptibility and insulin resistance (IR). It represents hepatic manifestation of metabolic syndrome (MS), and is associated with obesity, type 2 diabetes, hypertension, dyslipidemia, and metabolic syndrome. The prevalence of NAFLD increased year by year, and it is higher in the patients with type 2 diabetes and obesity. Atherosclerosis (AS) is the basic of cardiovascular disease (CVD), it is found that NAFLD was closely associated with CVD, and NAFLD was the cause of death in patients with CVD and malignant tumor. Also, there is a closely relationship between NAFLD and AS. The mechanism is not clear, and it may be related to insulin resistance, atherogenic dyslipidemia, oxidative stress, inflammation, the changes of fat hormone level and function in liver cell, etc. In this article, the relationship and possible mechanism between NAFLD and AS were reviewed.