天津医科大学学报
天津醫科大學學報
천진의과대학학보
Journal of Tianjin Medical University
2015年
6期
507-509
,共3页
肝硬化%乙型肝炎病毒%FibroTest%肝纤维化4项指标
肝硬化%乙型肝炎病毒%FibroTest%肝纖維化4項指標
간경화%을형간염병독%FibroTest%간섬유화4항지표
liver cirrhosis%hepatitis B virus%FibroTest%four serum liver fibrosis biomarkers
目的：探讨采用FibroTest（FT）与肝纤维化4项指标（肝纤4项）两种检测方法判断慢性乙型肝炎肝纤维化程度的意义。方法：留取90例慢性乙型肝炎患者血清，受试者均于同期进行肝穿刺活检，依据活检分期进行分组，分别检测α2巨球蛋白、结合珠蛋白、γ-谷氨酰转肽酶、总胆红素和载脂蛋白AⅠ5个指标，根据性别及年龄计算FT值，同时检测血清肝纤4项（透明质酸、层粘蛋白、Ⅲ型前胶原、Ⅳ型胶原），评价FT值和肝纤4项在慢性乙型肝炎肝纤维化程度判断中的价值。结果：肝脏病理纤维化分期为S0期5例（5.55%）、S1期49例（54.44%）、S2期24例(26.67%)、S3期7例（7.78%）、S4期5例（5.56%）。90例患者S 0、S 1、S 2、S 3、S 4期的各个检测值两两比较，差异具有统计学意义，P＜0．001。各检测值与肝脏病理分期呈正相关（P＜0.01）。结论：FibroTest联合肝纤4项在慢性乙型肝炎肝纤维化程度判断中有一定价值。
目的：探討採用FibroTest（FT）與肝纖維化4項指標（肝纖4項）兩種檢測方法判斷慢性乙型肝炎肝纖維化程度的意義。方法：留取90例慢性乙型肝炎患者血清，受試者均于同期進行肝穿刺活檢，依據活檢分期進行分組，分彆檢測α2巨毬蛋白、結閤珠蛋白、γ-穀氨酰轉肽酶、總膽紅素和載脂蛋白AⅠ5箇指標，根據性彆及年齡計算FT值，同時檢測血清肝纖4項（透明質痠、層粘蛋白、Ⅲ型前膠原、Ⅳ型膠原），評價FT值和肝纖4項在慢性乙型肝炎肝纖維化程度判斷中的價值。結果：肝髒病理纖維化分期為S0期5例（5.55%）、S1期49例（54.44%）、S2期24例(26.67%)、S3期7例（7.78%）、S4期5例（5.56%）。90例患者S 0、S 1、S 2、S 3、S 4期的各箇檢測值兩兩比較，差異具有統計學意義，P＜0．001。各檢測值與肝髒病理分期呈正相關（P＜0.01）。結論：FibroTest聯閤肝纖4項在慢性乙型肝炎肝纖維化程度判斷中有一定價值。
목적：탐토채용FibroTest（FT）여간섬유화4항지표（간섬4항）량충검측방법판단만성을형간염간섬유화정도적의의。방법：류취90례만성을형간염환자혈청，수시자균우동기진행간천자활검，의거활검분기진행분조，분별검측α2거구단백、결합주단백、γ-곡안선전태매、총담홍소화재지단백AⅠ5개지표，근거성별급년령계산FT치，동시검측혈청간섬4항（투명질산、층점단백、Ⅲ형전효원、Ⅳ형효원），평개FT치화간섬4항재만성을형간염간섬유화정도판단중적개치。결과：간장병리섬유화분기위S0기5례（5.55%）、S1기49례（54.44%）、S2기24례(26.67%)、S3기7례（7.78%）、S4기5례（5.56%）。90례환자S 0、S 1、S 2、S 3、S 4기적각개검측치량량비교，차이구유통계학의의，P＜0．001。각검측치여간장병리분기정정상관（P＜0.01）。결론：FibroTest연합간섬4항재만성을형간염간섬유화정도판단중유일정개치。
Objective:To investigate the diagnostic value of FibroTest combined with 4 serum liver fibrosis biomarkers for liver fibrosis in patients with chronic hepatitis B (CHB). Methods:Serum samples were collected from 90 CHB patients who underwent liver biopsy. Serum samples were tested for five indicators includingα2-macroglobulin (α2M),haptoglobin (HAP),γ-glutamyl peptidase (GGT),total bilirubin (BIL) and apolipoprotein AⅠ (Apo AⅠ) and then the FT values as well as the age and sex of patients were calculated.Four serum liver fibrosis biomarkers included hyaluronan,laminin,procollagenⅢ,typeⅣcollagen were tested. The diagnostic values of FibroTest and four serum liver fibrosis biomarkers for liver fibrosis in CHB patients were evaluated. Results:There were 5 cases (5.55%)in the S 0 stage (the pathological stage of liver fibrosis),49 cases(54.44%)in the S 1stage, 24 cases (26.67%) in the S 2 stage,7 cases(7.78%)in the S 3 stage and 5 cases (5.56%)in the S 4 stage. The values were significantly different between any two of the five stages (S 0-S 4)(all P<0.001). A positive correlation was found between the values and liver pathological stage(P<0.01). Conclusion:The combination of FibroTest and four serum liver fibrosis biomarkers can evaluate liver fibrosis in CHB patients .
