CAJ | 학술논문

目的：探讨2型糖尿病患者血清脑源性神经营养因子（BDNF）水平的变化及其临床意义。方法对90例2型糖尿病患者[糖尿病组，根据糖化血红蛋白（HbA1c）检测结果分为 HbA1c＜7％组（50例）、HbA1c（40例）≥7％组]和90例健康体检者（正常对照组）采用酶联免疫吸附试验检测血清 BDNF 水平，采用高效液相色谱法检测糖尿病组和正常对照组全血 HbA1c 水平，并对检测结果进行统计分析。结果与正常对照组比较，糖尿病组血清BDNF 水平明显降低，全血 HbA1c 水平明显升高（均 P ＜0．05）；与 HbA1c＜7％组比较，HbA1c≥7％组血清 BD-NF 水平明显降低（P ＜0．05）。结论2型糖尿病患者血清 BDNF 水平显著低于正常人群，可能与糖代谢水平有关。
목적：탐토2형당뇨병환자혈청뇌원성신경영양인자（BDNF）수평적변화급기림상의의。방법대90례2형당뇨병환자[당뇨병조，근거당화혈홍단백（HbA1c）검측결과분위 HbA1c＜7％조（50례）、HbA1c（40례）≥7％조]화90례건강체검자（정상대조조）채용매련면역흡부시험검측혈청 BDNF 수평，채용고효액상색보법검측당뇨병조화정상대조조전혈 HbA1c 수평，병대검측결과진행통계분석。결과여정상대조조비교，당뇨병조혈청BDNF 수평명현강저，전혈 HbA1c 수평명현승고（균 P ＜0．05）；여 HbA1c＜7％조비교，HbA1c≥7％조혈청 BD-NF 수평명현강저（P ＜0．05）。결론2형당뇨병환자혈청 BDNF 수평현저저우정상인군，가능여당대사수평유관。
ABSTRACT:Objective To discuss the change in serum brain-derived neurotrophic factor levels and its clinical significance in type 2 diabetic patients.Methods Serum BDNF levels were detec-ted by ELISA and blood glycosylated hemoglobin levels were measured by HPLC in 90 patients with type 2 diabetes(diabetes group,50 patients with HbA1c levels< 7% and 40 patients with HbA1c levels≥ 7%)and 90 healthy subjects(control group).Results Compared with control group,serum BDNF levels decreased and blood HbA1c levels increased in diabetes group(P <0.05).Compared with patients with HbA1c levels<7%,serum BDNF levels decreased in patients with HbA1c levels≥7%(P <0.05).Conclusion Compared with normal popylation serum BDNF levels significantly decreased in type 2 diabetic patients and may be related to the level of glucose metabolism.