CAJ | 학술논문

目的：综合评价解整合素金属蛋白酶33（ADAM33）基因V4位点多态性与儿童哮喘易感性的关系。方法制定统一的检索策略，检索Pubmed、Ovid-Medline、Embase、CNKI、维普及万方数据库中有关ADAM33基因多态性与哮喘易感性关系的病例-对照研究，按照纳入和排除标准选择文献提取相关信息，应用Review Manager 5．0软件进行Meta分析。纳入6篇合格文献，均满足遗传平衡检验，累计1435例儿童哮喘病例和1710例对照。结果在等位基因模型、显性模型和隐性模型中，ADAM33基因V4位点多态性与儿童支气管哮喘的易患性无关（ G与C：OR＝1．33，95％CI＝0．96－1．84，P＝0．09；CG＋GG与CC：OR＝1．41，95％CI＝0．95－2．08，P＝0．09；CC＋CG与GG：OR＝0．47，95％CI＝0．18－1．22，P＝0．12）。结论 AD-AM33基因V4位点多态性与儿童支气管哮喘的易感性无相关性。
목적：종합평개해정합소금속단백매33（ADAM33）기인V4위점다태성여인동효천역감성적관계。방법제정통일적검색책략，검색Pubmed、Ovid-Medline、Embase、CNKI、유보급만방수거고중유관ADAM33기인다태성여효천역감성관계적병례-대조연구，안조납입화배제표준선택문헌제취상관신식，응용Review Manager 5．0연건진행Meta분석。납입6편합격문헌，균만족유전평형검험，루계1435례인동효천병례화1710례대조。결과재등위기인모형、현성모형화은성모형중，ADAM33기인V4위점다태성여인동지기관효천적역환성무관（ G여C：OR＝1．33，95％CI＝0．96－1．84，P＝0．09；CG＋GG여CC：OR＝1．41，95％CI＝0．95－2．08，P＝0．09；CC＋CG여GG：OR＝0．47，95％CI＝0．18－1．22，P＝0．12）。결론 AD-AM33기인V4위점다태성여인동지기관효천적역감성무상관성。
Objective To study whether the polymorphisms of V4 in ADAM33 (A Disintegrin and Metalloproteinase 33) gene contribute to the susceptibility to childhood asthma.Methods According to the same criteria, all the clinical studies related to the polymorphism of ADAM33 gene and asthma were searched through PubMed, Ovid-Medline, Embase、CNKI, Wanfang and Weipu data-bases.All retrieved articles were screened and evaluated followed by meta-analysis using RevMan 5 software.Results Six studies were included based on the selection criteria.In these studies, 1435 childhood asthma and 1710 controls were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium.By meta-analysis, in allele and dominant models and re-cessive models,ADAM33 gene V4 polymorphism was not related to liability of childhood asthma ( G与C:OR=1.33,95%CI=0.96-1.84,P=0.09;CG+GG与CC:OR=1.41,95%CI=0.95-2.08,P=0.09;CC+CG与GG:OR=0.47,95%CI=0.18-1.22, P=0.12).Conclusion Polymorphism of ADAM33 V4 seems not to be involved in elevated risk of childhood asthma.