CAJ | 학술논문

目的：探讨复方氟米松软膏联合异维 A 酸红霉素凝胶治疗掌跖脓疱病临床疗效。方法将入选的46例掌跖脓疱病患者随机分为治疗组（23例）和对照组（23例）。治疗组每日外用复方氟米松软膏2次，晚上外用异维 A 酸红霉素凝胶1次；对照组每日复方氟米松软膏2次，疗程为8周，疗程结束后进行疗效评价。结果8周疗程结束后治疗组有效率为82.6%，而对照组有效率为52.2%，差异具有统计学意义（P <0.05）；随访三月后，治疗组和对照组复发率为5.3%和33.3%，差异具有统计学意义（P <0.05）。结论复方氟米松软膏联合异维 A 酸红霉素凝胶治疗掌跖脓疱病疗效好且复发率低，值得临床应用。
목적：탐토복방불미송연고연합이유 A 산홍매소응효치료장척농포병림상료효。방법장입선적46례장척농포병환자수궤분위치료조（23례）화대조조（23례）。치료조매일외용복방불미송연고2차，만상외용이유 A 산홍매소응효1차；대조조매일복방불미송연고2차，료정위8주，료정결속후진행료효평개。결과8주료정결속후치료조유효솔위82.6%，이대조조유효솔위52.2%，차이구유통계학의의（P <0.05）；수방삼월후，치료조화대조조복발솔위5.3%화33.3%，차이구유통계학의의（P <0.05）。결론복방불미송연고연합이유 A 산홍매소응효치료장척농포병료효호차복발솔저，치득림상응용。
Objective:To investigate the effects of compound flumetasone ointment combined with isotretinoine erythro-mycin gel in the treatment of palmoplantar pustulosis. Methods:Forty-six patients with palmoplantar pustulosis were ran-domly divided into treatment group(n = 23)and control group(n = 23). They were topically treated with compound flumeta-sone ointment twice a day,while the treatment group were treated with 0. 05% isotretinoin erythromycin gel once daily in the evening;the control group was only treated with compound flumetasone ointment twice a day. The efficacy was evalua-ted 8 weeks later. Results:Effective rate for the treatment group on the 8th week was 82. 6% ,while that of the control group was 52. 2% ,there was significant difference between the two groups(P < 0. 05). After three months follow up we found relapse rate of treatment group and control group were 5. 3% and 33. 3% ,and there was significant difference be-tween the two groups(P < 0. 05). Conclusion:The treatment of compound flumetasone ointment combined with isotretinoin erythromycin gel was effective,and the relapse rate was significantly lower,which is worth popularizing and applying to pal-moplantar pustulosis.