CAJ | 학술논문

目的：探讨 D 二聚体（D-D）、超敏 C 反应蛋白（hs-CRP）和肌钙蛋白 I（cTnI）联合检测应用于急性冠状动脉综合征早期诊断的价值及临床意义。方法选取我院2013年1月-2015年1月所收治急性冠状动脉综合征（ACS）患者122例，其中不稳定性心绞痛（UAP）患者27例、ST 段抬高型急性心肌梗死（STEMI）患者59例、非 ST段抬高型急性心肌梗死（NSTEMI）患者36例，选取同期53例健康体检者为对照组，均经冠状动脉造影检查，显示阴性。均进行 D-D、hs-CRP、cTnI 检测，并进行对比分析。结果 ACS 患者 D-D、hs-CRP、cTnI 水平均显著高于对照组，差异具有统计学意义（P <0.05）；且通过对比分析发现，对照组、UAP 组、NSTEMI 组及 STEMI 组各项检测数据均呈上升趋势，各组间数据比较，差异具有统计学意义（P <0.05）。结论 D 二聚体、超敏 C 反应蛋白联合检测应用于急性冠状动脉综合征早期诊断中，可有力补充传统肌钙蛋白 I 的不足，在评价病情严重程度、进行危险分层具有显著意义，值得临床推广应用。
목적：탐토 D 이취체（D-D）、초민 C 반응단백（hs-CRP）화기개단백 I（cTnI）연합검측응용우급성관상동맥종합정조기진단적개치급림상의의。방법선취아원2013년1월-2015년1월소수치급성관상동맥종합정（ACS）환자122례，기중불은정성심교통（UAP）환자27례、ST 단태고형급성심기경사（STEMI）환자59례、비 ST단태고형급성심기경사（NSTEMI）환자36례，선취동기53례건강체검자위대조조，균경관상동맥조영검사，현시음성。균진행 D-D、hs-CRP、cTnI 검측，병진행대비분석。결과 ACS 환자 D-D、hs-CRP、cTnI 수평균현저고우대조조，차이구유통계학의의（P <0.05）；차통과대비분석발현，대조조、UAP 조、NSTEMI 조급 STEMI 조각항검측수거균정상승추세，각조간수거비교，차이구유통계학의의（P <0.05）。결론 D 이취체、초민 C 반응단백연합검측응용우급성관상동맥종합정조기진단중，가유력보충전통기개단백 I 적불족，재평개병정엄중정도、진행위험분층구유현저의의，치득림상추엄응용。
Objective:To investigate the D two dimer,high sensitive C reactive protein and troponin I detection and clinical significance of combined application in the early diagnosis of acute coronary syndrome value. Methods:122 cases of patients with the acute coronary syndrome(ACS)admitted to our hospital in January 2013 - January 2015 the patients were selected,of which 27 cases of patients had unstable angina pectoris(UAP),59 cases of patients had acute ST seg-ment elevation myocardial infarction(STEMI)patients,and 36 cases had non ST segment elevation acute myocardial in-farction(NSTEMI). Fifty-three cases of healthy persons in the same period confirmed by coronary angiography negative were selected as the control group. All patients selected in this study had D two dimer,high sensitive C reactive protein and troponin I detection,and a comparative analysis was made. Results:D-D,hs-CRP,cTnI levels in patients with ACS were significantly higher than those in the control group,the difference was statistically significant(P < 0. 05);and he test data showed an upward trend compared to the control group,UAP group,NSTEMI group and STEMI group and the difference was statistically significant(P < 0. 05). Conclusion:D two dimmer and high sensitive C reactive protein used in the early diagnosis of acute coronary syndrome can effectively supplement the traditional troponin I,and it is significant in the evalua-tion of the severity of the disease and risk stratification,which is worthy of clinical application.