CAJ | 학술논문

目的：探讨左乙拉西坦为主三联治疗难治性癫痫疗效及安全性。方法选取我院近期收治难治性癫痫患者140例，采用随机数字表法分为对照组和试验组，每组各70例。对照组患者采用卡马西平+托吡酯治疗，试验组患者则在此基础上加用左乙拉西坦治疗；比较两组患者临床疗效，癫痫月发作次数及不良反应发生率等。结果试验组患者临床疗效显著优于对照组，差异有统计学意义（P <0.05）；试验组患者治疗后癫痫月发作次数显著低于对照组、治疗前，差异有统计学意义（P <0.05）；两组患者不良反应发生率比较差异无统计学意义（ P >0.05）。结论左乙拉西坦为主三联治疗难治性癫痫可有效改善症状体征，降低发作频率，且未增加不良反应发生风险。
목적：탐토좌을랍서탄위주삼련치료난치성전간료효급안전성。방법선취아원근기수치난치성전간환자140례，채용수궤수자표법분위대조조화시험조，매조각70례。대조조환자채용잡마서평+탁필지치료，시험조환자칙재차기출상가용좌을랍서탄치료；비교량조환자림상료효，전간월발작차수급불량반응발생솔등。결과시험조환자림상료효현저우우대조조，차이유통계학의의（P <0.05）；시험조환자치료후전간월발작차수현저저우대조조、치료전，차이유통계학의의（P <0.05）；량조환자불량반응발생솔비교차이무통계학의의（ P >0.05）。결론좌을랍서탄위주삼련치료난치성전간가유효개선증상체정，강저발작빈솔，차미증가불량반응발생풍험。
Objective:To investigate clinical effects and safety of levetiracetam for triple therapy on refractory epilepsy. Methods:140 patients with refractory epilepsy were chosen in recent years in our hospital and randomly divided into two groups including the control group(70 cases)with carbamazepine + topiramate and the experiment group(70 cases)with levetiracetam on the basis of control group;the clinical efficacy,epilepsy attack frequency per month and the incidence of adverse reactions of both groups were compared. Results:The clinical efficacy of the experiment group was significant better than that of the control group(P < 0. 05). The epilepsy attack frequency per month of the experiment group after treatment was significant better than that of the control group and before treatment(P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups(P > 0. 05). Conclusion:Levetiracetam for triple therapy on re-fractory epilepsy can efficiently improve clinical symptoms and signs and reduce attack frequency,with no increase of the risk of adverse reaction.