中国急救复苏与灾害医学杂志
中國急救複囌與災害醫學雜誌
중국급구복소여재해의학잡지
China Journal of Emergency Resuscitation and Disaster Medicine
2015年
10期
946-948
,共3页
地佐辛%丙泊酚%胃镜
地佐辛%丙泊酚%胃鏡
지좌신%병박분%위경
Dezocine%Propofol%Gastroscopy
目的：评估地佐辛联合丙泊酚在无痛电子胃镜检查中的临床效果和安全性。方法选择拟在丙泊酚静脉麻醉下行无痛电子胃镜检查的患者90例，随机分为D组（地佐辛＋丙泊酚组）、F组（芬太尼＋丙泊酚组），P组（丙泊酚组）每组30例。D组患者静脉注射地佐辛0.05 mg.kg-1，F组患者静脉注射芬太尼1μg.kg-1，3 min之后三组以效应室浓度为2.0μg/mL-1靶控注射丙泊酚，待BIS值降至70时开始胃镜检查。比较三组患者用药前（T0），麻醉后2 min（T1）及BIS达90时（T2）的HR、MAP、SpO2、RR的变化及不良反应发生情况。结果三组间丙泊酚用药量、苏醒时间差异有统计学意义（P＜0.05）。T1时D组、F组、MAP、HR、SpO2、RR较P组差异有统计学意义，D组、F组间SpO2、RR差异有统计学意义（P＜0.05）。结论0.05 mg.kg-1地佐辛在丙泊酚电子胃镜检查中具有良好的临床效果，可以减少丙泊酚用药量和呼吸抑制。
目的：評估地佐辛聯閤丙泊酚在無痛電子胃鏡檢查中的臨床效果和安全性。方法選擇擬在丙泊酚靜脈痳醉下行無痛電子胃鏡檢查的患者90例，隨機分為D組（地佐辛＋丙泊酚組）、F組（芬太尼＋丙泊酚組），P組（丙泊酚組）每組30例。D組患者靜脈註射地佐辛0.05 mg.kg-1，F組患者靜脈註射芬太尼1μg.kg-1，3 min之後三組以效應室濃度為2.0μg/mL-1靶控註射丙泊酚，待BIS值降至70時開始胃鏡檢查。比較三組患者用藥前（T0），痳醉後2 min（T1）及BIS達90時（T2）的HR、MAP、SpO2、RR的變化及不良反應髮生情況。結果三組間丙泊酚用藥量、囌醒時間差異有統計學意義（P＜0.05）。T1時D組、F組、MAP、HR、SpO2、RR較P組差異有統計學意義，D組、F組間SpO2、RR差異有統計學意義（P＜0.05）。結論0.05 mg.kg-1地佐辛在丙泊酚電子胃鏡檢查中具有良好的臨床效果，可以減少丙泊酚用藥量和呼吸抑製。
목적：평고지좌신연합병박분재무통전자위경검사중적림상효과화안전성。방법선택의재병박분정맥마취하행무통전자위경검사적환자90례，수궤분위D조（지좌신＋병박분조）、F조（분태니＋병박분조），P조（병박분조）매조30례。D조환자정맥주사지좌신0.05 mg.kg-1，F조환자정맥주사분태니1μg.kg-1，3 min지후삼조이효응실농도위2.0μg/mL-1파공주사병박분，대BIS치강지70시개시위경검사。비교삼조환자용약전（T0），마취후2 min（T1）급BIS체90시（T2）적HR、MAP、SpO2、RR적변화급불량반응발생정황。결과삼조간병박분용약량、소성시간차이유통계학의의（P＜0.05）。T1시D조、F조、MAP、HR、SpO2、RR교P조차이유통계학의의，D조、F조간SpO2、RR차이유통계학의의（P＜0.05）。결론0.05 mg.kg-1지좌신재병박분전자위경검사중구유량호적림상효과，가이감소병박분용약량화호흡억제。
Objective To investigate the effect and safety of dezocine in propofol painless gastroscopy. Methods A total of 90 patients (ASA I orⅡ) who underwent painless gastroscopy with propofol were randomly divided into three groups, group D (dezocine + propofol), group F (fentanyl + propofol) and group P (propofol), n=30. Group D was injected dezocine 0.05 mg.kg-1 intravenously while Group F was injected fentanyl 1 μg.kg-1 intravenously. Three minutes later all three groups were injected with propofol TCI with 2.0μg.ml-1 effect site concentration, and were started examination when the BIS reduced to 70. Their respective HR, MAP, SpO2, RR and adverse events were compared before anesthesia (T0) was given, 2 minutes after anesthesia (T1) and the BIS raised again to 90 (T2). Results It reflected a statistical difference in propofol dosage and awakening time after the examination among three groups (P<0.05). Comparing with group P while in T1, the MAP、HR、SpO2、RR of T1 were higher in both group D and group F (P<0.05). Conclusion Dezocine 0.05mg.kg-1 combined with propofol is considered being effective and safe during the painless gastroscopy which limited propofol dosage, and reduced respiratory depression.
