中国实验诊断学
中國實驗診斷學
중국실험진단학
Chinese Journal of Laboratory Diagnosis
2015年
11期
1901-1903
,共3页
赵树艳%Qin Huang-dao
趙樹豔%Qin Huang-dao
조수염%Qin Huang-dao
原发性肝癌%甲胎蛋白%甲胎蛋白异质体-L3%高尔基体蛋白 73
原髮性肝癌%甲胎蛋白%甲胎蛋白異質體-L3%高爾基體蛋白 73
원발성간암%갑태단백%갑태단백이질체-L3%고이기체단백 73
Primary Hepatocellular Cancer%Alpha fetoprotein%Alpha-fetoprotein L3%Golgi protein 73
目的：探讨甲胎蛋白（AFP）、甲胎蛋白异质体-L3（AFP-L3）、高尔基体蛋白73（GP73）在原发性肝癌的诊断价值。方法采用酶联免疫吸附法和电化学发光法检测68例原发性肝癌、49例良性肝病及68例健康体检者血清中 AFP、AFP-L3、GP73的含量，并进行比较。结果原发性肝癌患者组血清 AFP、AFP-L3、GP73含量明显高于良性肝病及健康对照组（P ＜0．05和 P ＜0．01）；三者联合检测的特异度和敏感度优于单独检测，所得数据有统计学意义。结论AFP、AFP-L3、GP73联合检测可明显提高原发性肝癌诊断的敏感性和特异性。
目的：探討甲胎蛋白（AFP）、甲胎蛋白異質體-L3（AFP-L3）、高爾基體蛋白73（GP73）在原髮性肝癌的診斷價值。方法採用酶聯免疫吸附法和電化學髮光法檢測68例原髮性肝癌、49例良性肝病及68例健康體檢者血清中 AFP、AFP-L3、GP73的含量，併進行比較。結果原髮性肝癌患者組血清 AFP、AFP-L3、GP73含量明顯高于良性肝病及健康對照組（P ＜0．05和 P ＜0．01）；三者聯閤檢測的特異度和敏感度優于單獨檢測，所得數據有統計學意義。結論AFP、AFP-L3、GP73聯閤檢測可明顯提高原髮性肝癌診斷的敏感性和特異性。
목적：탐토갑태단백（AFP）、갑태단백이질체-L3（AFP-L3）、고이기체단백73（GP73）재원발성간암적진단개치。방법채용매련면역흡부법화전화학발광법검측68례원발성간암、49례량성간병급68례건강체검자혈청중 AFP、AFP-L3、GP73적함량，병진행비교。결과원발성간암환자조혈청 AFP、AFP-L3、GP73함량명현고우량성간병급건강대조조（P ＜0．05화 P ＜0．01）；삼자연합검측적특이도화민감도우우단독검측，소득수거유통계학의의。결론AFP、AFP-L3、GP73연합검측가명현제고원발성간암진단적민감성화특이성。
Objective To investigate the application value of detection AFP,AFP-L3 and GP73 in the diagnosis of hepatocellular carcinoma.Methods Enzyme-linked immunosorbent assay (ELISA)was adopted to detect AFP、AFP-L3 and GP73 level of senum in hepatocellular carcinoma patients(68cases),benign liver disease (49 cases)and healthy people (68cases),and comparison was done.Results the Serum AFP,AFP-L3 and GP73 level in hepatocellular carci-noma were significantly higher than those of patients with benign liver diseases and control group (P < 0.05,P <0.01).The specificity and sensitivity of the combined detection of the three was better than that of the individual test, and the difference was statistically significant.Conclusion Combination test of serum AFP,AFP-L3 and GP73 has good diagrnosis value for hepatocellular carcinoma.
