国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
International Journal of Urology and Nephrology
2015年
6期
850-852
,共3页
金柯%王志荣%王强%宣枫%徐则乔
金柯%王誌榮%王彊%宣楓%徐則喬
금가%왕지영%왕강%선풍%서칙교
膀胱疾病%胆碱能拮抗剂
膀胱疾病%膽堿能拮抗劑
방광질병%담감능길항제
Urinary Bladder Diseases%Cholinergic Antagonist
目的 探讨治疗口服托特罗定无效的女性膀胱过度活动症(OAB)的有效方法.方法 选择诊断为OAB且口服托特罗定后无效的30例女性患者,给予口服托特罗定2mg/次,2次/d;坦索罗辛0.2mg,每晚1次;双氯芬酸钠25mg/次,2次/d.用药时间为4周,观察用药前后日平均排尿次数、日平均单次尿量、日单次最大尿量各指标变化.结果 联合治疗前患者日平均排尿次数(18±3)次,日平均单次尿量(105 ±31)mL,日平均单次最大尿量(15 4±30) mL;联合治疗后日平均排尿次数(10±2)次,日平均单次尿量(283 ±72) mL,日平均单次最大尿量(356±78)mL,治疗前后各观察指标比较,差异均有统计学意义(P＜0.05).结论 托特罗定联合坦索罗辛及双氯芬酸钠能够有效改善口服托特罗定无效的女性OAB患者临床症状,提高生活质量.
目的 探討治療口服託特囉定無效的女性膀胱過度活動癥(OAB)的有效方法.方法 選擇診斷為OAB且口服託特囉定後無效的30例女性患者,給予口服託特囉定2mg/次,2次/d;坦索囉辛0.2mg,每晚1次;雙氯芬痠鈉25mg/次,2次/d.用藥時間為4週,觀察用藥前後日平均排尿次數、日平均單次尿量、日單次最大尿量各指標變化.結果 聯閤治療前患者日平均排尿次數(18±3)次,日平均單次尿量(105 ±31)mL,日平均單次最大尿量(15 4±30) mL;聯閤治療後日平均排尿次數(10±2)次,日平均單次尿量(283 ±72) mL,日平均單次最大尿量(356±78)mL,治療前後各觀察指標比較,差異均有統計學意義(P＜0.05).結論 託特囉定聯閤坦索囉辛及雙氯芬痠鈉能夠有效改善口服託特囉定無效的女性OAB患者臨床癥狀,提高生活質量.
목적 탐토치료구복탁특라정무효적녀성방광과도활동증(OAB)적유효방법.방법 선택진단위OAB차구복탁특라정후무효적30례녀성환자,급여구복탁특라정2mg/차,2차/d;탄색라신0.2mg,매만1차;쌍록분산납25mg/차,2차/d.용약시간위4주,관찰용약전후일평균배뇨차수、일평균단차뇨량、일단차최대뇨량각지표변화.결과 연합치료전환자일평균배뇨차수(18±3)차,일평균단차뇨량(105 ±31)mL,일평균단차최대뇨량(15 4±30) mL;연합치료후일평균배뇨차수(10±2)차,일평균단차뇨량(283 ±72) mL,일평균단차최대뇨량(356±78)mL,치료전후각관찰지표비교,차이균유통계학의의(P＜0.05).결론 탁특라정연합탄색라신급쌍록분산납능구유효개선구복탁특라정무효적녀성OAB환자림상증상,제고생활질량.
Objectives To explore the efficacy of tolterodine in treating feminine overactive bladder.Methods Twenty patients were treated with tolterodine combined with tamsulosin anddiclofenacsodium.The total therapylasted 4 weeks.The time of urination perday,the average amount of mona-urination and the maximum amount of mona-urination were observed and the changes of all indexes before and after treatment were assessed.Results Before treatment,the daily mean frequency of urination was (18 ± 3)times,the daily mean single urine volume was(105 ± 31) mL and the daily mean maximum urine volume was (154 ± 30) mL.After treatment,the daily mean urination frequency was (10 ± 2) times,the daily mean single urinevolume was (283 ± 72)mL and thedaily mean maximum urinevolume was(356 ± 78)mL.All the indicators showed significantly differenct between before and after treatment(P ＜0.05).Conclusions Tolterodine combined with tamsulosin and diclofenac sodium can be an effective method for female over active bladder of tolterodine invalid.
