CAJ | 학술논문

目的探讨炎症因子对腹膜透析患者心脏结构和功能相关指标的影响.方法选择45例规律治疗3个月以上的腹膜透析患者,分别检测患者血浆中各种炎症因子,并应用心脏超声心动图测定LVDd、LVDs、LAD、IVST、LVPWT、LVEF等,计算左心室心肌重量指数(LVMI).结果腹膜透析患者血清炎症因子(hs-CRP,IL-6、TNF-α)水平均显著高于健康对照组及非终末期肾病组.分别与LAD、LVDd、LVDs、LVMI呈正相关,与LVEF呈负相关;hs-CRP分别与1L-6、TNF-α相互之间呈正相关.结论腹膜透析患者体内确实存在微炎症状态.炎症因子可能参与左心室重塑的发生和发展.
목적 탐토염증인자대복막투석환자심장결구화공능상관지표적영향.방법 선택45례규률치료3개월이상적복막투석환자,분별검측환자혈장중각충염증인자,병응용심장초성심동도측정LVDd、LVDs、LAD、IVST、LVPWT、LVEF등,계산좌심실심기중량지수(LVMI).결과 복막투석환자혈청염증인자(hs-CRP,IL-6、TNF-α)수평균현저고우건강대조조급비종말기신병조.분별여LAD、LVDd、LVDs、LVMI정정상관,여LVEF정부상관;hs-CRP분별여1L-6、TNF-α상호지간정정상관.결론 복막투석환자체내학실존재미염증상태.염증인자가능삼여좌심실중소적발생화발전.
Objectives To investigate the efficacy of high sensitivity C reactive protein (hs-CRP),interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) on left ventricular remodeling in patients with peritoneal dialysis.Methods Forty-five patients with peritoneal dialysis were selected,who underwent peritoneal dialvsis for more than three months and were in a stable clinic status without signs of acute infections or other progressive diseases.Serum hs-CRP,IL-6 and TNF-α were measured by ELISA.The left atrial diameter(LAD),1 eft ventricular end diastolic diameter(LVDd),inter ventricular septal thickness (IVST),left ventricular posterior wall thicknes (LVPWT) and left ventricular ejection fraction (LVEF) were measured by ultrasonic cardiography.Results Serum hs-CRP,IL-6 and TNF-α were significantly higher in patients than those in the normal control group(P ＜ 0.05) and non ESRD group.The average serum hs-CRP,IL-6 and TNF-c were positively correlated with the values of LAD,LVDd,LVDs,LVMI (P ＜0.05),but negatively corre1ated with the value of LVEF (P ＜0.05).Conclusions There is micro inflammatory state in the patients with peritoneal dialysis.The inflammatory factors are probably involved in the presence and progression of left ventricular remodeling in patients with Peritoneal Dialysis.