中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Version)
2015年
5期
636-639
,共4页
白细胞介素-28B%病毒性肝炎,丙型%基因多态性%易感性
白細胞介素-28B%病毒性肝炎,丙型%基因多態性%易感性
백세포개소-28B%병독성간염,병형%기인다태성%역감성
Interleukin-28B%Hepatitis C%Gene polymorphisms%Susceptibility
目的 探讨白细胞介素-28B(IL-28B)基因的多态性与新疆维吾尔族慢性丙型肝炎感染易感性的关联.方法 选取180例新疆维吾尔族慢性丙型肝炎患者作为HCV组,155例维族健康体检者作为健康对照组,通过PCR产物测序法检测两组受试者IL-28B rs8099917基因型和等位基因分布频率,对两组基因型和等位基因差异进行分析;同时在HCV组中,对不同IL-28B基因型人群的HCV RNA载量、肝功能和血脂水平等进行分析.结果 rs8099917在HCV组和健康对照组中TT和TG/GG基因型频率在新疆维族HCV组与健康对照组中差异具有统计学意义(χ2= 11.627、P = 0.001,OR = 1.363,95%CI:1.107~1.591);两组间G等位基因率差异显著,HCV组中占13.3%,健康对照组7.0%(χ2= 7.011、P = 0.008,OR = 0.658,95%CI:0.512~0.905).患者HCV RNA和肝功能血脂差异与IL-28B基因多态性中无关.结论 新疆维吾尔族人群中HCV的易感性IL-28B rs8099917基因多态性有关联,rs8099917中等位基因G是新疆维族HCV患者的易感基因.
目的 探討白細胞介素-28B(IL-28B)基因的多態性與新疆維吾爾族慢性丙型肝炎感染易感性的關聯.方法 選取180例新疆維吾爾族慢性丙型肝炎患者作為HCV組,155例維族健康體檢者作為健康對照組,通過PCR產物測序法檢測兩組受試者IL-28B rs8099917基因型和等位基因分佈頻率,對兩組基因型和等位基因差異進行分析;同時在HCV組中,對不同IL-28B基因型人群的HCV RNA載量、肝功能和血脂水平等進行分析.結果 rs8099917在HCV組和健康對照組中TT和TG/GG基因型頻率在新疆維族HCV組與健康對照組中差異具有統計學意義(χ2= 11.627、P = 0.001,OR = 1.363,95%CI:1.107~1.591);兩組間G等位基因率差異顯著,HCV組中佔13.3%,健康對照組7.0%(χ2= 7.011、P = 0.008,OR = 0.658,95%CI:0.512~0.905).患者HCV RNA和肝功能血脂差異與IL-28B基因多態性中無關.結論 新疆維吾爾族人群中HCV的易感性IL-28B rs8099917基因多態性有關聯,rs8099917中等位基因G是新疆維族HCV患者的易感基因.
목적 탐토백세포개소-28B(IL-28B)기인적다태성여신강유오이족만성병형간염감염역감성적관련.방법 선취180례신강유오이족만성병형간염환자작위HCV조,155례유족건강체검자작위건강대조조,통과PCR산물측서법검측량조수시자IL-28B rs8099917기인형화등위기인분포빈솔,대량조기인형화등위기인차이진행분석;동시재HCV조중,대불동IL-28B기인형인군적HCV RNA재량、간공능화혈지수평등진행분석.결과 rs8099917재HCV조화건강대조조중TT화TG/GG기인형빈솔재신강유족HCV조여건강대조조중차이구유통계학의의(χ2= 11.627、P = 0.001,OR = 1.363,95%CI:1.107~1.591);량조간G등위기인솔차이현저,HCV조중점13.3%,건강대조조7.0%(χ2= 7.011、P = 0.008,OR = 0.658,95%CI:0.512~0.905).환자HCV RNA화간공능혈지차이여IL-28B기인다태성중무관.결론 신강유오이족인군중HCV적역감성IL-28B rs8099917기인다태성유관련,rs8099917중등위기인G시신강유족HCV환자적역감기인.
Objective To study the association between interleukin-28B (IL-28B) single nucleotide polymorphism and susceptibility to hepatitis C virus infection in Xinjiang Uighur populition.Methods The IL-28B rs8099917 locus was genotyped in 180 patients infected with HCV and 150 healthy controls using the method of direct gene sequencing. The differences of SNPs genotypes and allele frequencies in the two groups were analyzed by statistics. The association between SNPs genotypes and allele frequencies and HCV RNA, liver function and blood lipid of chronic HCV were analyzed, respectively.Results TT and TG/GG genotype frequencies of rs8099917 differed signiifcantly between patients with chronic HCV and healthy controls (χ2= 11.627,P= 0.001;OR = 1.363, 95%CI: 1.107-1.591). Patients with HCV infection had a higher G allele frequency than healthy controls (χ2= 7.011,P = 0.008;OR = 0.658, 95%CI: 0.512-0.905).Conclusions The IL-28B rs8099917 gene polymorphism correlates with susceptibility to HCV infection in Uighur patient. G allele is associated with a higher risk of HCV infection.
