CAJ | 학술논문

菊糖是一种聚果糖，平均分子量介于3000～5000d 之间。目前对菊糖的研究集中于其提取方法、性质和在食品行业的应用，对其进行疏水改性的研究较少。本实验以 N，N -二甲基甲酰胺（ DMF）为溶剂，碳酸钾为碱性催化剂，通过转酯反应将月桂酸甲酯、肉豆蔻酸甲酯、棕榈酸甲酯以及油酸甲酯四种不同长度的脂肪酸链接枝到菊糖上，通过核磁共振氢谱验证产物结构，并对产物的理化性质及超声法制备的纳米粒的性质进行研究。结果表明，该合成方法能实现脂肪酸链的接枝以及菊糖的疏水改性；通过超声法可将产物制备成粒径100～300nm 的纳米粒，这些纳米粒可耐受胃液的酸性环境，常温下具有较好的放置稳定性，有望开发为疏水性纳米药物载体。
국당시일충취과당，평균분자량개우3000～5000d 지간。목전대국당적연구집중우기제취방법、성질화재식품행업적응용，대기진행소수개성적연구교소。본실험이 N，N -이갑기갑선알（ DMF）위용제，탄산갑위감성최화제，통과전지반응장월계산갑지、육두구산갑지、종려산갑지이급유산갑지사충불동장도적지방산련접지도국당상，통과핵자공진경보험증산물결구，병대산물적이화성질급초성법제비적납미립적성질진행연구。결과표명，해합성방법능실현지방산련적접지이급국당적소수개성；통과초성법가장산물제비성립경100～300nm 적납미립，저사납미립가내수위액적산성배경，상온하구유교호적방치은정성，유망개발위소수성납미약물재체。
Inulin is a kind of polymeric fructose, whose average molecular weight ranges from 3000 to 5000d.Currently the research on inulin focus on its purification method , property and its application in the field of food science , while few attempt the hydrophobic modification of inulin .In this experiment, we succeed in grafting four kinds of fatty acids with different length , including methyl laurate, methyl myristate, methyl palmitate and Oil methyl ester, to the long chain of inulin through transesterification.In this case, Dimethylformamide ( DMF) serves as solvent and Potassium carbonate functions as catalyst.Then we demonstrate the structure of product with the approach of nuclear magnetic resonance and conduct reaserch on the property of the product as well as the nanoparticle produced by unltrasonic method .The result reveals that we can manage the grafting of fatty acid and the hydrophobic modification .And the nanoparticles whose diameter ranges from 100to 300 nanometer can tolerate the acidic environment in stomach and manifest quite good stability in room temperaure.Itˊs promised to be exploited as hydrophobic medical carrier .