CAJ | 학술논문

目的： CT灌注成像参数与肺癌的病理类型及微血管生成有一定的关系，为进一步判断CT灌注成像参数评价肺癌临床预后的价值，本文探讨非小细胞肺癌（NSCLC）CT灌注成像参数血容量（BV）、血流量（BF）、对比剂到达峰值时间（TTP）和强化峰值（PEI）与微淋巴管密度（MLVD）的关系。资料与方法100例肺内单发结节患者行CT灌注扫描，其中60例经病理证实为NSCLC，采用免疫组化法观察60例NSCLC患者的MLVD表达，分析NSCLC患者CT灌注参数与MLVD表达的关系。结果 NSCLC患者MLVD在肺癌边缘组织分布最多（25.16±1.28），其次为肺癌中心组织（16.38±3.58），在正常肺组织中分布最少（7.56±4.38），差异有统计学意义（P<0.05）。肿瘤BF、BV与肿瘤MLVD计数呈正相关（r=0.643、0.598， P<0.01）。结论 CT灌注成像参数BF、BV与NSCLC患者肿瘤微淋巴管生成有关，可在一定程度上预测肺癌的侵袭及转移。
목적： CT관주성상삼수여폐암적병리류형급미혈관생성유일정적관계，위진일보판단CT관주성상삼수평개폐암림상예후적개치，본문탐토비소세포폐암（NSCLC）CT관주성상삼수혈용량（BV）、혈류량（BF）、대비제도체봉치시간（TTP）화강화봉치（PEI）여미림파관밀도（MLVD）적관계。자료여방법100례폐내단발결절환자행CT관주소묘，기중60례경병리증실위NSCLC，채용면역조화법관찰60례NSCLC환자적MLVD표체，분석NSCLC환자CT관주삼수여MLVD표체적관계。결과 NSCLC환자MLVD재폐암변연조직분포최다（25.16±1.28），기차위폐암중심조직（16.38±3.58），재정상폐조직중분포최소（7.56±4.38），차이유통계학의의（P<0.05）。종류BF、BV여종류MLVD계수정정상관（r=0.643、0.598， P<0.01）。결론 CT관주성상삼수BF、BV여NSCLC환자종류미림파관생성유관，가재일정정도상예측폐암적침습급전이。
PurposeThere is a certain correlation between parameters of CT perfusion imaging and pathological type and angiogenesis in lung cancer, in order to discuss the value of CT perfusion imaging parameters such as blood volume (BV), blood flow (BF), time to peak (TTP) and peak enhancement image (PEI) for prognosis, this study is designed to observe the relationship between the parameters of CT perfusion imaging and micro lymphovascular density (MLVD) in non-small cell lung cancer (NSCLC).Materials and Methods 100 patients were enrolled in the study, all of them underwent CT perfusion imaging and 60 were diagnosed NSCLC by pathology, immunohistochemical staining was performed to determine the expressions of MLVD of the 60 NSCLC, and the correlation analyses were carried out to determine the relationship between CT perfusion imaging and MLVD.Results The expression of MLVD was the most in the peripheral tissue of cancer (25.16±1.28), the next in the cancer tissue (16.38±3.58), and the least in the normal lung tissue (7.56±4.38), the difference was statistically significant (P<0.05). There was positive correlation between MLVD with BF and BV of the tumor (r=0.643 and 0.598, P<0.01).Conclusion Some parameters of CT perfusion imaging are correlated with MLVD, the invasion and metastasis in lung carcinoma can be predicted to some extent according to this correlation. Parameters of CT perfusion imaging such as BF and BV are correlated with MLVD in patients with NSCLC, thus can be used to predict the invasion and metastasis of lung cancer.