临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
Journal of Clinical and Experimental Medicine
2015年
22期
1870-1872
,共3页
蔡克影%李芹%梁必会%王红梅%张庆娥
蔡剋影%李芹%樑必會%王紅梅%張慶娥
채극영%리근%량필회%왕홍매%장경아
子宫内膜异位症%促性腺激素释放激素激动剂%左炔诺孕酮宫内缓释系统
子宮內膜異位癥%促性腺激素釋放激素激動劑%左炔諾孕酮宮內緩釋繫統
자궁내막이위증%촉성선격소석방격소격동제%좌결낙잉동궁내완석계통
Endometriosis%GnRH - a%Levonorgestrel
目的：探讨促性腺激素释放激素激动剂（GnRH -α）联合左炔诺孕酮宫内缓释系统（LNG - IUS）治疗腹腔镜术后复发性卵巢子宫内膜异位症的临床疗效。方法选取腹腔镜下卵巢子宫内膜异位症手术后患者90例，根据患者意愿分为3组。其中 A 组29例，单纯应用 GnRH -α进行治疗；B 组30例，单纯采用 LNG - IUS 治疗；C 组31例，采用GnRH -α联合 LNG - IUS 治疗。在术前及术后第3、6、12、24个月进行随访，对痛经评分、手术后的复发率、血清糖类抗原 CA125水平等进行比较。结果所有患者术后1年内痛经评分均较术前显著降低，A 组和 C 组在随访3个月、6个月时痛经评分、血清 CA125水平降低比 B 组明显，差异有统计学意义（ P ﹤0.05）；随访2年内，A、B、C 三组患者的异位囊肿复发率分别为34.48％、13.33％、9.68％，C 组复发率明显低于 A 组和 B 组，差异有统计学意义（ P ﹤0.05）。结论腹腔镜下卵巢子宫内膜异位症手术后 GnRH -α联合 LNG - IUS 治疗可以有效地缓解痛经，降低异位囊肿的复发率，而且安全性高、持续时间长、不良反应少，有利于患者病情的缓解。6 months，dysmenorrhea score and serum CA125 level were lower than B group obviously，the difference was statistically significant（ P ﹤0.05）. Follow - up of 2 years，ectopic cyst recurrence rates of three groups of patients were 34.48％，13.33％，9.68％. Conclusion GnRH -α com-bined with LNG - IUS therapy can effectively alleviate dysmenorrhea，reduce cyst recurrence rate，and be high safety，long duration，less adverse reaction，there is ease to patients.
目的：探討促性腺激素釋放激素激動劑（GnRH -α）聯閤左炔諾孕酮宮內緩釋繫統（LNG - IUS）治療腹腔鏡術後複髮性卵巢子宮內膜異位癥的臨床療效。方法選取腹腔鏡下卵巢子宮內膜異位癥手術後患者90例，根據患者意願分為3組。其中 A 組29例，單純應用 GnRH -α進行治療；B 組30例，單純採用 LNG - IUS 治療；C 組31例，採用GnRH -α聯閤 LNG - IUS 治療。在術前及術後第3、6、12、24箇月進行隨訪，對痛經評分、手術後的複髮率、血清糖類抗原 CA125水平等進行比較。結果所有患者術後1年內痛經評分均較術前顯著降低，A 組和 C 組在隨訪3箇月、6箇月時痛經評分、血清 CA125水平降低比 B 組明顯，差異有統計學意義（ P ﹤0.05）；隨訪2年內，A、B、C 三組患者的異位囊腫複髮率分彆為34.48％、13.33％、9.68％，C 組複髮率明顯低于 A 組和 B 組，差異有統計學意義（ P ﹤0.05）。結論腹腔鏡下卵巢子宮內膜異位癥手術後 GnRH -α聯閤 LNG - IUS 治療可以有效地緩解痛經，降低異位囊腫的複髮率，而且安全性高、持續時間長、不良反應少，有利于患者病情的緩解。6 months，dysmenorrhea score and serum CA125 level were lower than B group obviously，the difference was statistically significant（ P ﹤0.05）. Follow - up of 2 years，ectopic cyst recurrence rates of three groups of patients were 34.48％，13.33％，9.68％. Conclusion GnRH -α com-bined with LNG - IUS therapy can effectively alleviate dysmenorrhea，reduce cyst recurrence rate，and be high safety，long duration，less adverse reaction，there is ease to patients.
목적：탐토촉성선격소석방격소격동제（GnRH -α）연합좌결낙잉동궁내완석계통（LNG - IUS）치료복강경술후복발성란소자궁내막이위증적림상료효。방법선취복강경하란소자궁내막이위증수술후환자90례，근거환자의원분위3조。기중 A 조29례，단순응용 GnRH -α진행치료；B 조30례，단순채용 LNG - IUS 치료；C 조31례，채용GnRH -α연합 LNG - IUS 치료。재술전급술후제3、6、12、24개월진행수방，대통경평분、수술후적복발솔、혈청당류항원 CA125수평등진행비교。결과소유환자술후1년내통경평분균교술전현저강저，A 조화 C 조재수방3개월、6개월시통경평분、혈청 CA125수평강저비 B 조명현，차이유통계학의의（ P ﹤0.05）；수방2년내，A、B、C 삼조환자적이위낭종복발솔분별위34.48％、13.33％、9.68％，C 조복발솔명현저우 A 조화 B 조，차이유통계학의의（ P ﹤0.05）。결론복강경하란소자궁내막이위증수술후 GnRH -α연합 LNG - IUS 치료가이유효지완해통경，강저이위낭종적복발솔，이차안전성고、지속시간장、불량반응소，유리우환자병정적완해。6 months，dysmenorrhea score and serum CA125 level were lower than B group obviously，the difference was statistically significant（ P ﹤0.05）. Follow - up of 2 years，ectopic cyst recurrence rates of three groups of patients were 34.48％，13.33％，9.68％. Conclusion GnRH -α com-bined with LNG - IUS therapy can effectively alleviate dysmenorrhea，reduce cyst recurrence rate，and be high safety，long duration，less adverse reaction，there is ease to patients.
Objective To investigate the clinical efficacy of GnRH - α combined with LNG - IUS in recurrent ovarian endometriosis pa-tients after laparoscopic surgery. Methods 90 cases of ovarian endometriosis were included into the present study. According to the wishes of pa-tients,all these cases were divided into 3 groups. 29 cases of A group,the simple application of GnRH - α treatment;30 cases in group B,trea-ted by LNG - IUS;31 cases in group C,using GnRH - α combined with LNG - IUS therapy. At the time of before and after the operation,6,12, 24 months for follow - up dysmenorrhea score,the rate of recurrence after operation,the level of serum carbohydrate antigen CA125,were recorded and compared. Results Dysmenorrhea of all patients at 1 years significantly decreased. In A group and C group in the follow - up of 3 months 6 months,dysmenorrhea score and serum CA125 level were lower than B group obviously,the difference was statistically significant( P ﹤0. 05). Follow - up of 2 years,ectopic cyst recurrence rates of three groups of patients were 34. 48%,13. 33%,9. 68%. Conclusion GnRH - α combined with LNG - IUS therapy can effectively alleviate dysmenorrhea,reduce cyst recurrence rate,and be high safety,long duration,less adverse reaction,there is ease to patients.
