CAJ | 학술논문

目的：探讨早期应用复合辅酶联合维生素 E 在治疗新生儿高胆红素血症中对肝肾功能的保护作用。方法将133例足月高胆红素血症新生儿随机分为两组，观察组（n =68）给予静滴复合辅酶和维生素 E 以及常规治疗；对照组（n =65）仅给予常规干预。比较两组患儿治疗前后血清γ-谷氨酰转移酶（γ- GGT）、总胆红素及胱抑素 C（Cys -C）、丙二醛（MDA）等指标变化。结果所有患儿治疗后γ- GGT、Cys - C 和 MDA 均较治疗前有所下降，而观察组较对照组下降幅度更显著（ P ﹤0.05）。结论高胆红素血症对新生儿肝肾功能有较大损害，复合辅酶联合维生素 E 通过胆红素诱导的脂质过氧化作用，可有效降低血清胆红素水平，对患儿肝肾产生一定保护作用。
목적：탐토조기응용복합보매연합유생소 E 재치료신생인고담홍소혈증중대간신공능적보호작용。방법장133례족월고담홍소혈증신생인수궤분위량조，관찰조（n =68）급여정적복합보매화유생소 E 이급상규치료；대조조（n =65）부급여상규간예。비교량조환인치료전후혈청γ-곡안선전이매（γ- GGT）、총담홍소급광억소 C（Cys -C）、병이철（MDA）등지표변화。결과소유환인치료후γ- GGT、Cys - C 화 MDA 균교치료전유소하강，이관찰조교대조조하강폭도경현저（ P ﹤0.05）。결론고담홍소혈증대신생인간신공능유교대손해，복합보매연합유생소 E 통과담홍소유도적지질과양화작용，가유효강저혈청담홍소수평，대환인간신산생일정보호작용。
Objective To explore the protection role in the early proper coenzyme complex combined with vitamin E in the treatment of neonatal hyperbilirubinemia on the function of liver and kidney. Methods 133 cases of full - term newborns with hyperbilirubinemia were ran-domly divided into two groups. The observed group(n = 68)was given intravenous drip and coenzyme complex vitamin E and conventional thera-py. The patient of control group(n = 65)only received routine intervention. The serum gamma glutamyl transfer enzyme(γ - GGT),total biliru-bin and cystatin C(Cys),malondialdehyde(MDA)and indicators of change were compared between the two groups before and after treatment in children. Results After treatment,γ - GGT,Cys - C and MDA decreased,while the observation group was significantly lower than those of the control group( P ﹤ 0. 05). Conclusion Hyperbilirubinemia on neonatal liver and kidney function have greater harm,coenzyme complex com-bined with vitamin E by bilirubin induced lipid peroxidation. This method can effectively reduce the level of serum bilirubin,liver and kidney of children have some protective effect.