CAJ | 학술논문

目的：探讨甘氨酸补充对一次力竭性运动小鼠部分生化指标的影响。方法将雄性昆明小鼠分为3组，每组10只：力竭性游泳运动组（E组），甘氨酸补充后力竭性游泳组（G组）及静息正常对照组（S组）。G组小鼠采用甘氨酸灌胃处理4周，其余两组给予生理盐水。4周后，E组和G组均做力竭性游泳运动。采样后进行补体溶血活性测定，并测定血清中部分生化指标的水平。结果与E组比较，G组的力竭性游泳运动时间显著延长（P＜0．01）。力竭性游泳后，E组小鼠血清中丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、尿素氮、血清铁（Fe3＋）和补体溶血活性（CHA）的水平较S组发生了显著性的变化（P＜0．01），与E组比较，G组小鼠血清中上述生化指标得到了显著改善（P＜0．01），其中ALP和LDH的水平可以恢复到与S组相当的水平（P＞0．05）。结论力竭性游泳小鼠血清部分生化指标异常，甘氨酸预补充对这些异常有明显的改善作用，可以一定程度地提高小鼠的运动能力。
목적：탐토감안산보충대일차력갈성운동소서부분생화지표적영향。방법장웅성곤명소서분위3조，매조10지：력갈성유영운동조（E조），감안산보충후력갈성유영조（G조）급정식정상대조조（S조）。G조소서채용감안산관위처리4주，기여량조급여생리염수。4주후，E조화G조균주력갈성유영운동。채양후진행보체용혈활성측정，병측정혈청중부분생화지표적수평。결과여E조비교，G조적력갈성유영운동시간현저연장（P＜0．01）。력갈성유영후，E조소서혈청중병안산안기전이매（ALT）、천동안산안기전이매（AST）、감성린산매（ALP）、유산탈경매（LDH）、기산격매（CK）、뇨소담、혈청철（Fe3＋）화보체용혈활성（CHA）적수평교S조발생료현저성적변화（P＜0．01），여E조비교，G조소서혈청중상술생화지표득도료현저개선（P＜0．01），기중ALP화LDH적수평가이회복도여S조상당적수평（P＞0．05）。결론력갈성유영소서혈청부분생화지표이상，감안산예보충대저사이상유명현적개선작용，가이일정정도지제고소서적운동능력。
Objective To investigate the influence of glycine supplement on partial biochemical indicator in exhaustive exer‐cise mice .Methods Divided Kunming′s male‐mice into 3 group(10/group):exhaustive swimming group(E) ,exhaustive swimming group with glycine supplement(G) and silent control group (S) .Mice in the G group was treated with 4‐weeked intragastric admin‐istration of glycine ,while mice in other 2 groups received physiological saline .After 4 weeks ,mice in E and G group did the exhaus‐tive swimming exercise .After sampling ,the activity of complement hemolytic activity was measured ,and the serum levels of some biochemical indexes were determined .Results Time of exhaustive swimming in G group was significantly longer than E group(P<0 .01) .After exhaustive swimming ,the ALT ,AST ,ALP ,LDH ,CK ,N ,Fe3+ and CHA in E group were significantly changed com‐pared with S group(P<0 .01);while those indicators in G group were significantly improved than E group (P<0 .01) ,the ALP and LDH level can regain to the level of S group (P>0 .05) .Conclusion Exhaustive swimming mice can have part indicator abnormali‐ty ,but Glycine supplement can effectively improve that condition and enhance the exercise ability to some extent .