CAJ | 학술논문

目的：探讨健康体检人群幽门螺杆菌（Hp）感染与同型半胱氨酸（Hcy ）的关系。方法选取2012年12月至2013年9月在该院体检中心接受健康体检的930例普通人群作为研究对象，采用免疫胶体金法测定 H p感染情况，根据 H p感染情况分为Hp阳性组（n＝465）和Hp阴性组（n＝465例），同时应用化学发光仪通过荧光偏振免疫检测法检测血浆总 Hcy（tHcy），分析Hp感染与 Hcy之间的关系。结果受检930例人群中，Hp阳性组tHcy水平高于阴性组（P＞0．05）；Hp阳性组tHcy水平升高的异常率68．39％，Hp阴性组tHcy水平升高的异常率44．30％，两组差异有统计学意义（P＜0．05）；Hp阳性组男性tHcy水平异常率88．25％，女性tHcy水平异常率18．80％；Hp阴性组男性Hcy水平异常率59．76％，女性Hcy水平异常率5．30％，组间同性别异常率及组内不同性别比较差异有统计学意义（P＜0．05，P＜0．01）。结论 Hp感染可能是导致高 Hcy血症的危险因素之一，应积极开展 Hp感染的防治，以减少心脑血管疾病的发生。
목적：탐토건강체검인군유문라간균（Hp）감염여동형반광안산（Hcy ）적관계。방법선취2012년12월지2013년9월재해원체검중심접수건강체검적930례보통인군작위연구대상，채용면역효체금법측정 H p감염정황，근거 H p감염정황분위Hp양성조（n＝465）화Hp음성조（n＝465례），동시응용화학발광의통과형광편진면역검측법검측혈장총 Hcy（tHcy），분석Hp감염여 Hcy지간적관계。결과수검930례인군중，Hp양성조tHcy수평고우음성조（P＞0．05）；Hp양성조tHcy수평승고적이상솔68．39％，Hp음성조tHcy수평승고적이상솔44．30％，량조차이유통계학의의（P＜0．05）；Hp양성조남성tHcy수평이상솔88．25％，녀성tHcy수평이상솔18．80％；Hp음성조남성Hcy수평이상솔59．76％，녀성Hcy수평이상솔5．30％，조간동성별이상솔급조내불동성별비교차이유통계학의의（P＜0．05，P＜0．01）。결론 Hp감염가능시도치고 Hcy혈증적위험인소지일，응적겁개전 Hp감염적방치，이감소심뇌혈관질병적발생。
Objective To explore the relationship between helicobacter pylori infections and homocysteine (Hcy) in health checkup population .Methods A total of 930 health checkup people in our hospital physical examination center during December 2012 to September 2013 were selected as the research object and were divided into Hp positive group (465 cases) and the negative group (465 cases) according to the Hp infection by the immune colloidal gold method .The level of Hcy was measured in two groups by fluorescence polarization immunoassay method .The relationship between helicobacter pylori infections and homocysteine was analyzed .Results The abnormal rate of high serum level of Hcy in Hp positive group was 68 .39% ,While 44 .30% in negative group ,the difference was statistically significant (P<0 .05);the abnormal rate of male was 88 .25% ,female 18 .80% ;the abnormal rate of male was 59 .76% ,and that of female was 5 .30% ,the difference of two groups had statistical significance (P<0 .05 ,P<0 .01) .Conclusion Hp infection may be a risk factor of high Hcy levels ,and taking measures actively to prevent and control Hp in‐fection may reduce the of the cardiovascular and cerebrovascular diseases .