CAJ | 학술논문

目的：探讨4种不同子宫内膜准备方案在冻融胚胎移植（FET ）中的应用价值。方法回顾性分析2013年3月至2015年3月在清远市人民医院生殖医学中心进行的320个FET周期，其中自然周期组（A组）70周期，促排卵组（B组）152周期，激素替代组（C组）74周期，降调后激素替代组（D组）24周期，比较4组FET的治疗结局。结果 B、C、D组的临床妊娠率和胚胎种植率均显著高于A组（P＜0．05）；4组的多胎妊娠率、生化妊娠率、早期妊娠流产率和异位妊娠率等指标间的差异均无统计学意义（P＞0．05）；D组FET周期次数显著高于其他3组（P＜0．05）。结论在FET 中，促排卵、激素替代和降调后激素替代方案均可获得良好的治疗结局，降调后激素替代方案在既往移植失败患者中具有较好疗效。
목적：탐토4충불동자궁내막준비방안재동융배태이식（FET ）중적응용개치。방법회고성분석2013년3월지2015년3월재청원시인민의원생식의학중심진행적320개FET주기，기중자연주기조（A조）70주기，촉배란조（B조）152주기，격소체대조（C조）74주기，강조후격소체대조（D조）24주기，비교4조FET적치료결국。결과 B、C、D조적림상임신솔화배태충식솔균현저고우A조（P＜0．05）；4조적다태임신솔、생화임신솔、조기임신유산솔화이위임신솔등지표간적차이균무통계학의의（P＞0．05）；D조FET주기차수현저고우기타3조（P＜0．05）。결론재FET 중，촉배란、격소체대화강조후격소체대방안균가획득량호적치료결국，강조후격소체대방안재기왕이식실패환자중구유교호료효。
Objective To estimate the clinical value of 4 methods of endometrium preparation for frozen‐thawed embryo transfer(FET ) cycle .Methods Total 320 FET cycles completed in center of reproductive medicine of Qingyuan people′s hospital from March 2013 to March 2015 were retrospectively analyzed ,and divided into 4 groups :natural cycle group(group A ,n=70) ,o‐vulation‐inducing cycle group(group B ,n=152) ,hormone replacement treatment(HRT) cycle group (group C ,n=74) ,down‐regu‐lated HRT cycle (group D ,n=24) .The pregnancy outcomes were followed and compared among these different 4 groups .Results In FET cycles ,the clinical pregnancy rates and implantation rates of group B ,group C and group D were significantly higher than that of group A (P<0 .05) ,there were no significant differences in the rates of multiple pregnancy ,biochemical pregnancy ,early a‐bortion and ectopic pregnancy among 4 groups(P>0 .05) .However ,the rank of the FET cycle of group D was significantly higher than those of the other three groups(P<0 .05) .Conclusion In FET cycles ,the methods of ovulation‐inducing ,HRT and down‐reg‐ulated HRT all have favorable clinical outcomes ,and the method of down‐regulated HRT is more suitable for patients with previous implantation failure .