CAJ | 학술논문

目的：探讨同型半胱氨酸（Hcy）、N-末端脑钠肽前体（NT-proBNP）和超敏C反应蛋白（hs-CRP）在急性脑梗死患者梗死面积大小和病程进展情况中的变化。方法对该院2012～2014年收治的80例急性脑梗死患者（研究组）和80例健康体检者（对照组）的血清中Hcy、NT-proBNP和hs-CRP水平进行比较。结果研究组患者血清中Hcy、NT-proBNP和hs-CRP的水平明显高于对照组，差异有统计学意义（P＜0．05）；其中研究组患者中大面积梗死亚组患者血清中 Hcy、NT-proBNP和hs-CRP的水平明显高于小面积梗死亚组，差异有统计学意义（P＜0．05）。结论 Hcy、NT-proBNP和hs-CRP三者的联合检测可作为脑梗死面积大小和病程进展情况的监测指标。
목적：탐토동형반광안산（Hcy）、N-말단뇌납태전체（NT-proBNP）화초민C반응단백（hs-CRP）재급성뇌경사환자경사면적대소화병정진전정황중적변화。방법대해원2012～2014년수치적80례급성뇌경사환자（연구조）화80례건강체검자（대조조）적혈청중Hcy、NT-proBNP화hs-CRP수평진행비교。결과연구조환자혈청중Hcy、NT-proBNP화hs-CRP적수평명현고우대조조，차이유통계학의의（P＜0．05）；기중연구조환자중대면적경사아조환자혈청중 Hcy、NT-proBNP화hs-CRP적수평명현고우소면적경사아조，차이유통계학의의（P＜0．05）。결론 Hcy、NT-proBNP화hs-CRP삼자적연합검측가작위뇌경사면적대소화병정진전정황적감측지표。
Objective To investigate the changes of homocysteine(Hcy) ,N-terminal pro-brain natriuretic peptide(NT-proBNP) and high sensitive C reactive protein(hs-CRP) changes in different area of infarction size and disease progression patients with acute cerebral infarction .Methods From 2012 to 2014 ,the levels of Hcy ,NT-proBNP and hs-CRP were analyzed and compared in a total of 80 patients with acute cerebral infarction(study group) and 80 healthy subjects(control group) .Results The contents of Hcy , NT-proBNP and hs-CRP in the study group were significant higher than those of the control group ,the differences had statistical significance(P<0 .05) .The contents of Hcy ,NT-proBNP and hs-CRP in patients with large area cerebral infarction were significant higher than those in small size cerebral infarction patients ,the differences had statistical significance(P<0 .05) .Conclusion The combined detection of Hcy ,NT-proBNP and hs-CRP could be used as indicators for monitoring cerebral infarction size and disease progress .